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Akademický článek

Arsenic is a potent co-mutagen of ultraviolet light

Autor: Rachel M. Speer, Shuvro P. Nandi, Karen L. Cooper, Xixi Zhou, Hui Yu, Yan Guo, Laurie G. Hudson, Ludmil B. Alexandrov, Ke Jian Liu

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)

Abstract Arsenic enhances the carcinogenicity of ultraviolet radiation (UVR). However, the mechanisms of arsenic-driven oncogenesis are not well understood. Here, we utilize experimental systems to investigate the carcinogenic and mutagenic propertie

Externí odkaz: https://doaj.org/article/f2b3976df61a4e12854326502c2e7c85

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Akademický článek

Effect of trunk exercise upon lumbar IVD height and vertebral compliance when performed supine with 1 g at the CoM compared to upright in 1 g

Autor: D. Marcos-Lorenzo, T. Frett, A. Gil-Martinez, M. Speer, J. Swanenburg, D. A. Green

Publikováno v: BMC Sports Science, Medicine and Rehabilitation, Vol 14, Iss 1, Pp 1-11 (2022)

Abstract Background Spinal unloading in microgravity is associated with stature increments, back pain, intervertebral disc (IVD) swelling and impaired spinal kinematics. The aim of this study was to determine the effect of lateral stabilization, trun

Externí odkaz: https://doaj.org/article/343d14cfc56348b09196ba6cf9a68db1

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Akademický článek

Building bridges: a review and synthesis of research on teaching knowledge for undergraduate instruction in science, engineering, and mathematics

Autor: Tessa C. Andrews, Natasha M. Speer, Ginger V. Shultz

Publikováno v: International Journal of STEM Education, Vol 9, Iss 1, Pp 1-21 (2022)

Abstract Here, we systematically review research on teaching knowledge in the context of undergraduate STEM education, with particular attention to what this research reveals about knowledge that is important for evidence-based teaching. Evidence-bas

Externí odkaz: https://doaj.org/article/bc11bd5a0b674192903e18af887340c6

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Akademický článek

The synaptic basis of activity-dependent eye-specific competition

Autor: Chenghang Zhang, Swapnil Yadav, Colenso M. Speer

Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112085- (2023)

Summary: Binocular vision requires proper developmental wiring of eye-specific inputs to the brain. In the thalamus, axons from the two eyes initially overlap in the dorsal lateral geniculate nucleus and undergo activity-dependent competition to segr

Externí odkaz: https://doaj.org/article/e451124b61b44196a2460bcac9e7a7b1

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Akademický článek

Volumetric super-resolution imaging by serial ultrasectioning and stochastic optical reconstruction microscopy in mouse neural tissue

Autor: Tarlan Vatan, Jacqueline A. Minehart, Chenghang Zhang, Vatsal Agarwal, Jerry Yang, Colenso M. Speer

Publikováno v: STAR Protocols, Vol 2, Iss 4, Pp 100971- (2021)

Summary: Here, we present a protocol for collecting large-volume, four-color, single-molecule localization imaging data from neural tissue. We have applied this technique to map the location and identities of chemical synapses across whole cells in m

Externí odkaz: https://doaj.org/article/2f090f4fe5694afe9a6c8349d4c2a85e

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Akademický článek

A Picture Worth a Thousand Molecules—Integrative Technologies for Mapping Subcellular Molecular Organization and Plasticity in Developing Circuits

Autor: Jacqueline A. Minehart, Colenso M. Speer

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 12 (2021)

A key challenge in developmental neuroscience is identifying the local regulatory mechanisms that control neurite and synaptic refinement over large brain volumes. Innovative molecular techniques and high-resolution imaging tools are beginning to res

Externí odkaz: https://doaj.org/article/f509e93759a74dd19dbbf77b02fad5f0

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Akademický článek

A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues

Autor: Esther M. Speer, Elizabet Diago-Navarro, Lukasz S. Ozog, Mahnoor Raheel, Ofer Levy, Bettina C. Fries

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Introduction: Neonatal sepsis triggers an inflammatory response that contributes to mortality and multiple organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses pro-inflammatory cytokines, is a candidate adjunctive therap

Externí odkaz: https://doaj.org/article/1d1e849025ad4ae58935abd260aed09f

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