Výsledky vyhledávání

Akademický článek

Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels

Publikováno v: Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-14 (2022)

Abstract Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination of postmortem brains of participants with antemor

Externí odkaz: https://doaj.org/article/4d7fc8dcbfb540b2928a445f125243c0

Zobrazit plný text záznamu

Plný text ve formátu HTML

(298) MRI Measurement of Perineal and Pelvic Muscles as a Novel Imaging Marker for Hypogonadism

Autor: Z Blake, D Nemirovsky, J Enders, A Pillai, M Rothberg, J Noun, W Dahut, F Karzai, P Pinto, B Turkbey, S Gurram

Publikováno v: The Journal of Sexual Medicine. 20

Introduction Low serum testosterone (T) in the presence of clinical symptoms of hypogonadism is essential in determining who may benefit from T replacement therapy. However, clinical symptoms associated with hypogonadism are non-specific and challeng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bcc55d663ea16291d8de15024beb91c
https://doi.org/10.1093/jsxmed/qdad060.279

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex

Autor: Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L. Lewis Jr., Christopher Conrad, Jonathan M. Rothberg, Jonathan O. Lipton, Stefan Kölker, Georg F. Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin

Publikováno v: Cell Reports, Vol 17, Iss 4, Pp 1053-1070 (2016)

Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same ti

Externí odkaz: https://doaj.org/article/5ed8e2bf932447198481e0e69bebd50d

Zobrazit plný text záznamu

Supplementary Figure 1 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Autor: Robert J. Gillies, Robert A. Gatenby, Joseph Johnson, Bonnie F. Sloane, Jennifer M. Rothberg, Yoganand Balagurunathan, Kate Bailey, Arig Ibrahim-Hashim, Heather H. Cornnell, Jonathan Wojtkowiak, Mark Lloyd, Tingan Chen, Veronica Estrella

PDF file - 287K, Figure S1: Photomicrographs of cells in this study. HMEC, HCT116/GFP and MDAmb231 cells were grown to 70-80% confluency. Samples were then viewed with an automated Zeiss Observer Z.1 inverted microscope through a 10x /0.3NA or 20x/0.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b423cd5b0bf700d7b220e59f853176
https://doi.org/10.1158/0008-5472.22399074

Zobrazit plný text záznamu

Supplementary Figure 2 from Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Autor: Robert J. Gillies, Bonnie F. Sloane, Mark C. Lloyd, Joshua B. Proemsey, Edward Haller, Karla J. Schramm, Virendra Kumar, Jennifer M. Rothberg, Jonathan W. Wojtkowiak

PDF file - 241K, Histological analysis of LC3 spatial expression patterns in relation to pimonidazole hydrochloride (Hypoxia) and Glut1 expression. MDA-MB-231 MFP tumor was histologically stained for LC3, Glut1, and pimonidazole hydrochloride. Pixel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eb7e9cdf609d834a80106a3be4b0fc
https://doi.org/10.1158/0008-5472.22391631

Zobrazit plný text záznamu

Supplementary Figure 5 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion

PDF file - 43K, Figure S5: Relation between tumor growth and pH for all 5 mice. Data for all 5 mice were parsed as in figure 2D wherein the growth (in pixels) and pH were calculated every 22.5o of arc. These data show that growth increased with decre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3643bc931def5225ab0dc040c7c16b
https://doi.org/10.1158/0008-5472.22399059.v1

Zobrazit plný text záznamu

Supplementary Figure 3 from Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Autor: Robert J. Gillies, Bonnie F. Sloane, Mark C. Lloyd, Joshua B. Proemsey, Edward Haller, Karla J. Schramm, Virendra Kumar, Jennifer M. Rothberg, Jonathan W. Wojtkowiak

PDF file - 431K, Histological analysis of in-vivo LC3 expression in HS766T subcutaneous tumors buffered with sodium bicarbonate. (A) Whole cell lysates from HS766T cells cultured at neutral pH 7.4 or pH 6.7 for 48 hours were analyzed for LC3-II expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5bccdfdb9906bb431380bcab3b43fe
https://doi.org/10.1158/0008-5472.22391628

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání