Zobrazeno 1 - 10
of 905
pro vyhledávání: '"M, Rho"'
Autor:
Devansh Agarwal, Nicholas Dash, Kevin W. Mazo, Manan Chopra, Maria P. Avila, Amit Patel, Ryan M. Wong, Cairang Jia, Hope Do, Jie Cheng, Colette Chiang, Shawna L. Jurlina, Mona Roshan, Michael W. Perry, Jong M. Rho, Risa Broyer, Cassidy D. Lee, Robert N. Weinreb, Cezar Gavrilovici, Nicholas W. Oesch, Derek S. Welsbie, Karl J. Wahlin
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract In optic neuropathies, including glaucoma, retinal ganglion cells (RGCs) die. Cell transplantation and endogenous regeneration offer strategies for retinal repair, however, developmental programs required for this to succeed are incompletely
Externí odkaz:
https://doaj.org/article/382428f7635b42d8a434f9b8270d4a90
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104565- (2023)
Summary: Background: Extracellular signal-regulated kinase (ERK/MAPK) pathway in the brain is hypothesized to be a critical convergent node in the development of autism spectrum disorder. We reasoned that selectively targeting this pathway could reve
Externí odkaz:
https://doaj.org/article/ce1d4dbd6e25492382c12539cd1ca4b5
Autor:
Samantha L. Baglot, Catherine Hume, Gavin N. Petrie, Robert J. Aukema, Savannah H. M. Lightfoot, Laine M. Grace, Ruokun Zhou, Linda Parker, Jong M. Rho, Stephanie L. Borgland, Ryan J. McLaughlin, Laurent Brechenmacher, Matthew N. Hill
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal models that reflect human consumption are critical to study the impact of cannabis on brain and behaviour. Most animal studie
Externí odkaz:
https://doaj.org/article/04850bd70616448ebc370986b3f128f7
Autor:
P. Wijdenes, K. Haider, C. Gavrilovici, B. Gunning, M. D. Wolff, T. Lijnse, R. Armstrong, G. C. Teskey, J. M. Rho, C. Dalton, Naweed I. Syed
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Neural recordings made to date through various approaches—both in-vitro or in-vivo—lack high spatial resolution and a high signal-to-noise ratio (SNR) required for detailed understanding of brain function, synaptic plasticity, and dysfun
Externí odkaz:
https://doaj.org/article/07111a50d0a94ec8bdbd64b85d857050
Autor:
Mackenzie Cervenka, Juan M. Pascual, Jong M. Rho, Elizabeth Thiele, Gary Yellen, Vicky Whittemore, Adam L. Hartman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1730-1737 (2021)
Abstract Objective Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism‐based therapies are not always effective. Methods We consider the state of
Externí odkaz:
https://doaj.org/article/1e15fb0a7a6a4961a5cff490e46f79de
Autor:
Jeffrey R. Buchhalter, Morris H. Scantlebury, Sabrina D’Alfonso, Juan Pablo Appendino, Luis Bello Espinosa, Brian L. Brooks, Curtis Claassen, Jane Corbeil, David Czank, Stafford Dean, Alice W. Ho, Julia Jacobs, Maarit Mackay, Joka McMahon, Aleksandra Mineyko, Jong M. Rho, Trina Roberts, Sonia Rothenmund, Gary Ruta, Tyson Sawchuk, Brett A. Simms, Kim Smyth, Tammy Still, Nancy Thornton
Publikováno v:
Epilepsia Open, Vol 6, Iss 2, Pp 345-358 (2021)
Abstract Objective To describe the development of the Pediatric Epilepsy Outcome‐Informatics Project (PEOIP) at Alberta Children's Hospital (ACH), which was created to provide standardized, point‐of‐care data entry; near‐time data analysis; a
Externí odkaz:
https://doaj.org/article/d6fbdae1b37f4ed4ba403f1f5aa126d1
Autor:
Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Anamika Choudhary, Melinda Wang, Wendie N. Marks, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketog
Externí odkaz:
https://doaj.org/article/dbf57edf6907492dbc659ea52050e2c9
Publikováno v:
NeuroImage, Vol 250, Iss , Pp 118935- (2022)
Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood. It is possible that mitochondrial damage may be associated with m
Externí odkaz:
https://doaj.org/article/27d0e39bb8bf4660b9bedefbf77cc20c
Autor:
Xiaoqin Zhan, Hadhimulya Asmara, Ning Cheng, Giriraj Sahu, Eduardo Sanchez, Fang-Xiong Zhang, Gerald W. Zamponi, Jong M. Rho, Ray W. Turner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce e
Externí odkaz:
https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c
Autor:
Shyamchand Mayengbam, Jacob Ellegood, Mitch Kesler, Raylene A. Reimer, Jane Shearer, Kartikeya Murari, Jong M. Rho, Jason P. Lerch, Ning Cheng
Publikováno v:
NeuroImage, Vol 244, Iss , Pp 118542- (2021)
Ketogenic diet (KD) is a high-fat and low-carbohydrate therapy for medically intractable epilepsy, and its applications in other neurological conditions, including those occurring in children, have been increasingly tested. However, how KD affects ch
Externí odkaz:
https://doaj.org/article/af22871adb5c49c0b622087c1f02cd02