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Akademický článek

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

Autor: Nivedita M. Ratnam, Heather M. Sonnemann, Stephen C. Frederico, Huanwen Chen, Marsha-Kay N. D. Hutchinson, Tyrone Dowdy, Caitlin M. Reid, Jinkyu Jung, Wei Zhang, Hua Song, Meili Zhang, Dionne Davis, Mioara Larion, Amber J. Giles, Mark R. Gilbert

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Glioblastoma (GBM) is an aggressive brain malignancy with a dismal prognosis. With emerging evidence to disprove brain-immune privilege, there has been much interest in examining immunotherapy strategies to treat central nervous system (CNS) cancers.

Externí odkaz: https://doaj.org/article/c849550f38044b1bba008d2e7a7de887

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Akademický článek

Making a Cold Tumor Hot: The Role of Vaccines in the Treatment of Glioblastoma

Autor: Stephen C. Frederico, John C. Hancock, Emily E. S. Brettschneider, Nivedita M. Ratnam, Mark R. Gilbert, Masaki Terabe

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

The use of immunotherapies for the treatment of brain tumors is a topic that has garnered considerable excitement in recent years. Discoveries such as the presence of a glymphatic system and immune surveillance in the central nervous system (CNS) hav

Externí odkaz: https://doaj.org/article/6c385229f31a47ec8b41a83b81552ba6

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Akademický článek

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug

Externí odkaz: https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195

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Akademický článek

Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy

Autor: Amber J. Giles, Marsha-Kay N. D. Hutchinson, Heather M. Sonnemann, Jinkyu Jung, Peter E. Fecci, Nivedita M. Ratnam, Wei Zhang, Hua Song, Rolanda Bailey, Dionne Davis, Caitlin M. Reid, Deric M. Park, Mark R. Gilbert

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)

Abstract Background Corticosteroids are routinely utilized to alleviate edema in patients with intracranial lesions and are first-line agents to combat immune-related adverse events (irAEs) that arise with immune checkpoint blockade treatment. Howeve

Externí odkaz: https://doaj.org/article/dbbd8ceab8b343afa6a998b078f2f24a

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Akademický článek

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Akademický článek

NF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells

Autor: David J. Wang, Nivedita M. Ratnam, John C. Byrd, Denis C. Guttridge

Publikováno v: Cell Reports, Vol 9, Iss 1, Pp 90-103 (2014)

Summary: NF-κB is considered a major contributor to tumor development, but how this factor functions in the initial stages of oncogenesis is not clear. In a model of Ras-induced transformation, we probed NF-κB function as preneoplastic cells formed

Externí odkaz: https://doaj.org/article/1a69a652d6da404fa0327c44767c9317

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Weather and its impact on population buildup of pod borers in pigeonpea

Autor: MV Ramana, M Sreekanth, M Ratnam

Publikováno v: International Journal of Chemical Studies. 8:2477-2481

The experiment conducted at Regional Agricultural Research Station, Lam, Guntur during 2016-17 on pigeonpea (Cajanus cajan (L.) Millspaugh) yielded a good amount of information on the trend of population build up and seasonal abundance of gram pod bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a273b5939bf0c8d1abc9802d7d83a1d9
https://doi.org/10.22271/chemi.2020.v8.i5ah.10691

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