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Data from Intravesical Delivery of Rapamycin Suppresses Tumorigenesis in a Mouse Model of Progressive Bladder Cancer

Autor: Cory Abate-Shen, James Mc Kiernan, Carlos Cordon-Cardo, Shalini Jain, Trushar Patel, Anna M. Puzio-Kuter, Catherine M. Seager

Early-stage bladder cancer occurs as two distinct forms: namely, low-grade superficial disease and high-grade carcinoma in situ (CIS), which is the major precursor of muscle-invasive bladder cancer. Although the low-grade form is readily treatable, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f74d99d43143c740b4857e14d44b13
https://doi.org/10.1158/1940-6207.c.6543586.v1

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Data from ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer

Autor: Cory Abate-Shen, Hikmat A. Al-Ahmadie, David B. Solit, Tian Zheng, Nikolaus Schultz, Jingqiang Wang, Francisco Sánchez-Vega, Min Yuen Teo, Gopa Iyer, Anna M. Puzio-Kuter, Lijie Rong, Ricardo Ramirez, Takashi Kobayashi, Tomasz B. Owczarek

Muscle-invasive bladder cancer (MIBC) generally responds poorly to treatment and tends to exhibit significant mortality. Here we show that expression of the tumor suppressor p14ARF (ARF) is upregulated in aggressive subtypes of MIBC. Accumulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ceef8c6d1a9e8fe7032524f8e0c8d9d
https://doi.org/10.1158/0008-5472.c.6509324.v1

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Abstract 1295: Small molecule reactivators of Y220C mutant p53 modulate tumor infiltrating leukocytes and synergize with immune checkpoint inhibitors

Autor: Anna M. Puzio-Kuter, Chris Mulligan, Brandon Russo, Amy Wiebesiek, Lizhong Xu, Hong Yang, Binh Vu, Melissa Dumble

Publikováno v: Cancer Research. 82:1295-1295

Half of human cancers possess mutations in the TP53 gene, with most clustering as hotspots in the DNA binding domain. A tyrosine to cysteine substitution at amino acid 220 of the p53 protein (Y220C) is one such hotspot mutation (~1% of all solid tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b567661855b57c06f9fae6bd939fc4e
https://doi.org/10.1158/1538-7445.am2022-1295

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Abstract LB006: PC14586: The first orally bioavailable small molecule reactivator of Y220C mutant p53 in clinical development

Autor: Binbin Liu, Bruce Fahr, Kuo-Sen Huang, Anna M. Puzio-Kuter, Melissa Dumble, Dafydd G. Thomas, Hong Yang, Lizhong Xu, Kimberly Robell, Thomas P. Davis, Romyr Dominique, Binh Vu, Mary-Kate McBrayer, Chris Mulligan, Brandon Russo, Hongju Li

Publikováno v: Cancer Research. 81:LB006-LB006

Mutations in the TP53 gene are the most frequent somatic alterations in human cancer; approximately 50% of all human cancers possess mutations in TP53. Missense mutations in TP53 which result in a non-functional protein are the most frequently identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e3cf9286bb2818a390e41161956ac40
https://doi.org/10.1158/1538-7445.am2021-lb006

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Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma

Autor: Y Sun, Mireia Castillo-Martin, Saurabh V. Laddha, Carlos Cordon-Cardo, Arnold J. Levine, Chang S. Chan, Anna M. Puzio-Kuter

Publikováno v: Cell Death and Differentiation

Liposarcoma (LPS) is a type of soft tissue sarcoma that mostly occurs in adults, and in humans is characterized by amplifications of MDM2 and CDK4. The molecular pathogenesis of this malignancy is still poorly understood and, therefore, we developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eced724cde834e472c72df47ec64a502
http://europepmc.org/articles/PMC4648325

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Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li–Fraumeni cancer predisposition syndrome

Autor: Soo Sin Choong, Hany Ariffin, Kok-Siong Chen, Arnold J. Levine, Shekhar Krishnan, Anna M. Puzio-Kuter, Chang S. Chan, Maria Isabel Achatz, Denis Tolkunov, Jannah Shamsani, Gunaretnam Rajagopal, Adelyne S. L. Chan, Mawar Karsa, Wenfeng Kang, Leon Li Wen Lim, Pierre Hainaut

Publikováno v: Proceedings of the National Academy of Sciences. 111:15497-15501

The Li-Fraumeni syndrome (LFS) and its variant form (LFL) is a familial predisposition to multiple forms of childhood, adolescent, and adult cancers associated with germ-line mutation in the TP53 tumor suppressor gene. Individual disparities in tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e52593a135d8fb87c8d299bdee881b
https://doi.org/10.1073/pnas.1417322111

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