Utility of an Untargeted Metabolomics Approach Using a 2D GC-GC-MS Platform to Distinguish Relapsing and Progressive Multiple Sclerosis

Autor: Indrani Datta, Insha Zahoor, Nasar Ata, Faraz Rashid, Mirela Cerghet, Ramandeep Rattan, Laila M. Poisson, Shailendra Giri

Publikováno v: Metabolites, Vol 14, Iss 9, p 493 (2024)

Multiple sclerosis (MS) is the most common inflammatory neurodegenerative disease of the central nervous system (CNS) in young adults and results in progressive neurological defects. The relapsing-remitting phenotype (RRMS) is the most common disease

Externí odkaz: https://doaj.org/article/8bbdd1a3afd548199767b6c9b06f3386

Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis

Autor: Indrani Datta, Houtan Noushmehr, Chaya Brodie, Laila M. Poisson

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-9 (2021)

Abstract Background Clinically relevant glioma subtypes, such as the glioma-CpG island methylator phenotype (G-CIMP), have been defined by epigenetics. In this study, the role of long non-coding RNAs in association with the poor-prognosis G-CMIP-low

Externí odkaz: https://doaj.org/article/a64883cad66b4276ab1a947fbb9d9a5f

Development of ‘Core Outcome Sets’ for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings

Autor: James Snyder, Nisaharan Srikandarajah, Boris Krischek, Matthias Preusser, Michael Weller, Timothy J Kaufmann, Thomas Santarius, Carole Turner, Michael D Cusimano, Paula R Williamson, Michael McDermott, Michael D Jenkinson, Justin Wang, Mohsen Javadpour, Andrea Saladino, Anthony G Marson, David James, Chaya Brodie, Daniel M Fountain, Roland Goldbrunner, Felix Sahm, Sylvia Kurz, Colin Watts, Julian Spears, Amir H Zamanipoor Najafabadi, Simon Walling, Andrew Morokoff, Ghazaleh Tabatabai, Helen Shih, Linda Dirven, Puneet Plaha, Helen Bulbeck, David Schultz, Christian Mawrin, Jens Schittenhelm, Farshad Nassiri, Martin J B Taphoorn, Manfred Westphal, Warren Selman, C Oliver Hanemann, Patrick Y Wen, Mirjam Renovanz, Evanthia Galanis, Alireza Mansouri, Priscilla K Brastianos, Christine Jungk, Heather Barrington, Aaron Cohen-Gadol, Gelareh Zadeh, Abdurrahman I Islim, Christopher P Millward, Theo Georgious, Andrew R Brodbelt, Karolyn Au, Felix Behling, Nicholas Butowski, Ana Castro, Marta Couce, Francesco Dimeco, Craig Erker, Michelle Felicella, Norbert Galldiks, Caterina Giannini, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Gerhard Jungwirth, Daniel Lachance, Christian Lafougere, Katrin Lamszus, Serge Makarenko, Tathiana Malta, Jennifer Moliterno-Gunel, Houtan Noushmehr, Arie Perry, Aditya Ragunathan, David Raleigh, Franz Ricklefs, Antonio Santacroce, Christian Schichor, Andrew Sloan, Matija Snuderl, Erik Sulman, Suganth Suppiah, Marcos Tatagiba, Marco Timmer, Andreas Von Deimling, Tobias Walbert, Stephen Yip, Gabriel Zada, Viktor Zherebitskiy, Derek Tsang, Kenneth Aldape, Terri S Armstrong, Sabrina Bell, Anna Crofton, Paul L Grundy, Sumirat M Keshwara, Shelli D Koszdin, Michael W McDermott, Torstein R Meling, Kathy Oliver, Jill Barnhartz-Sloan, Wenya Linda Bi, Carlos Carlotti, Katharine Drummond, Ian F Dunn, Brent Griffith, Rintaro Hashizume, Raymond Y Huang, Ian Lee, Jeff C Liu, Yasin Mamatjan, David Munoz, Ho-Keung Ng, Farhad Pirouzmand, Laila M Poisson, Bianca Pollo, Nils O Schmidt, Daniela Tirapelli, Joerg C Tonn, Michael A Vogelbaum, Adriana M Workewych

Publikováno v: BMJ Open, Vol 12, Iss 5 (2022)

Introduction Meningioma is the most common primary intracranial tumour in adults. The majority are non-malignant, but a proportion behave more aggressively. Incidental/minimally symptomatic meningioma are often managed by serial imaging. Symptomatic

Externí odkaz: https://doaj.org/article/e6f0561f8df642f8988cb2020bf5eb8a

Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors

Autor: Grayson A Herrgott, Karam P Asmaro, Michael Wells, Thais S Sabedot, Tathiane M Malta, Maritza S Mosella, Kevin Nelson, Lisa Scarpace, Jill S Barnholtz-Sloan, Andrew E Sloan, Warren R Selman, Ana C deCarvalho, Laila M Poisson, Abir Mukherjee, Adam M Robin, Ian Y Lee, James Snyder, Tobias Walbert, Mark Rosenblum, Tom Mikkelsen, Arti Bhan, John Craig, Steven Kalkanis, Jack Rock, Houtan Noushmehr, Ana Valeria Castro

Publikováno v: Neuro-Oncology. 24:1126-1139

Background DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations in circulating cell-free DNA (cfDNA) has been reported for several central nervous system (CNS) tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35424c8cddc7421b6e9620f44ee1f9cf
https://doi.org/10.1093/neuonc/noac050

Figure S2 from T2–FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project

Autor: Rajan Jain, Andrew S. Chi, John G. Golfinos, Adam E. Flanders, Brent Griffith, Ana M. Franceschi, Cheddhi Thomas, Matija Snuderl, Lee Cooper, Yueren Zhou, Daniel J. Brat, Laila M. Poisson, Sohil H. Patel

Kaplan-Meier curves demonstrating progression free survival and overall survival associated with the LGGs from the TCGA/TCIA database. Blue curves represent IDHmut-Codel gliomas, dotted black curves represent IDHmut-Noncodel gliomas that were positiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7feab09b1e8822879544ef8fcf7a9281
https://doi.org/10.1158/1078-0432.22463592.v1