Výsledky vyhledávání

Lung transplantation for acute exacerbation of interstitial lung disease

Autor: Ayoub Innabi, Diana Gomez-Manjarres, Divya C Patel, Bashar Alzghoul, M. Chizinga, Tiago N. Machuca, A. Shahmohammadi, Vanessa Scheuble, M. Pipkin, Christine Lin, A. Pelaez, Borna Mehrad

Publikováno v: Thorax

BackgroundAcute exacerbations of interstitial lung diseases (AE-ILD) have a high mortality rate with no effective medical therapies. Lung transplantation is a potentially life-saving option for patients with AE-ILD, but its role is not well establish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1168929632aee530060de9285142a522
https://doi.org/10.1136/thoraxjnl-2020-215681

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A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury

Publikováno v: Am J Transplant

Complement is known to play a role in ischemia and reperfusion injury (IRI). A general paradigm is that complement is activated by self-reactive natural IgM antibodies (nAbs), after they engage postischemic neoepitopes. However, a role for nAbs in lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eb961987b231379889459f9450ee4b
https://doi.org/10.1111/ajt.16404

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Akademický článek

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Successful bridge to lung transplantation with transcatheter aortic valve replacement

Autor: S. Chandrashekaran, George J. Arnaoutakis, A. Pelaez, Thomas M. Beaver, Tiago N. Machuca, Bruce D. Spiess, M. Pipkin, A. Shahmohammadi, A. Emtiazjoo, Tyler J. Wallen

Publikováno v: American Journal of Transplantation. 20:3658-3661

End-stage lung disease and advanced cardiac conditions are frequently seen together and represent a clinical dilemma. Even though both issues may be amenable to surgical management, combining lung transplant with surgical valve repair is rarely done

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac20ba4c35049aecb94063962cff33db
https://doi.org/10.1111/ajt.16103

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Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state

Autor: Himanshu Gogoi, Lei Jin, Divya S. Katikaneni, A. Emtiazjoo, Samira Mansouri, Tiago N. Machuca, M. Pipkin

Publikováno v: Mucosal Immunology. 13:595-608

The lung is a naturally tolerogenic organ. Lung regulatory T cells (T-regs) control lung mucosal tolerance. Here, we identified a lung IFNAR1hiTNFR2+ conventional DC2 (iR2D2) population that induces T-regs in the lung at steady state. Using condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0534159addfbe7b89e423d45225b8a34
https://doi.org/10.1038/s41385-020-0254-1

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In vivo reprogramming of pathogenic lung TNFR2 + cDC2s by IFNβ inhibits HDM-induced asthma

Autor: Tiago N. Machuca, Samira Mansouri, Lei Jin, Himanshu Gogoi, Ashish Sharma, M. Pipkin, A. Emtiazjoo

Publikováno v: Science Immunology. 6

Asthma is a common inflammatory lung disease with no known cure. Previously, we uncovered a lung TNFR2+ conventional DC2 subset (cDC2s) that induces regulatory T cells (Tregs) maintaining lung tolerance at steady state but promotes TH2 response durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61283495cea1b6a2f904dc2cf9cda79c
https://doi.org/10.1126/sciimmunol.abi8472

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Donor prone positioning protects lungs from injury during warm ischemia

Publikováno v: American Journal of Transplantation. 19:2746-2755

A large proportion of controlled donation after circulatory death (cDCD) donor lungs are declined because cardiac arrest does not occur within a suitable time after the withdrawal of life-sustaining therapy. Improved strategies to preserve lungs afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a4f81d22eea645320a37101bf53cca
https://doi.org/10.1111/ajt.15363

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