Zobrazeno 1 - 10
of 196
pro vyhledávání: '"M, Petkov"'
Autor:
Teresa Giannattasio, Erika Testa, Ramona Palombo, Lidia Chellini, Flavia Franceschini, Álvaro Crevenna, Petko M. Petkov, Maria Paola Paronetto, Marco Barchi
Publikováno v:
Cellular and Molecular Life Sciences. 80
In mammals, meiotic recombination is initiated by the introduction of DNA double strand breaks (DSBs) into narrow segments of the genome, defined as hotspots, which is carried out by the SPO11/TOPOVIBL complex. A major player in the specification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa55c6fbdb31bbeb8bc0679f2bb8890
https://doi.org/10.1007/s00018-023-04744-5
https://doi.org/10.1007/s00018-023-04744-5
Akademický článek
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Autor:
Yiping Wang, April Feswick, Vasiliki Apostolou, Petko M. Petkov, Emily K. Moser, Scott A. Tibbetts
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(32)
The germinal center (GC) plays a central role in the generation of antigen-specific B cells and antibodies. Tight regulation of the GC is essential due to the inherent risks of tumorigenesis and autoimmunity posed by inappropriate GC B cell processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a248ef6cd5171d688ec17446af79bdda
https://pubmed.ncbi.nlm.nih.gov/35921433
https://pubmed.ncbi.nlm.nih.gov/35921433
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007657 (2018)
In most mammals, including mice and humans, meiotic recombination is determined by the meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences and trimethylates histone 3 at lysine-4 and lysine-36 at the adjacent nucleo
Externí odkaz:
https://doaj.org/article/3fd5077a7f4d4ca6a97aaffd3500ded9
Autor:
Anna L Tyler, Catrina Spruce, Romy Kursawe, Annat Haber, Robyn L Ball, Wendy A Pitman, Alexander D Fine, Narayanan Raghupathy, Michael Walker, Vivek M Philip, Christopher L Baker, J. Matthew Mahoney, Gary A. Churchill, Jennifer J Trowbridge, Michael L Stitzel, Kenneth Paigen, Petko M Petkov, Gregory W Carter
It is well established that epigenetic features, such as histone modifications and DNA methylation, are associated with variation in gene expression across cell types. Less well known is the extent to which epigenetic states vary across genetically d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64401d5023c67c4a301ed7a92a30a68
https://doi.org/10.1101/2022.11.02.514900
https://doi.org/10.1101/2022.11.02.514900
Akademický článek
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Akademický článek
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Publikováno v:
Molecular Biology of the Cell
Meiotic recombination in most mammals requires recombination hotspot activation through the action of the histone 3 Lys-4 and Lys-36 methyltransferase PRDM9 to ensure successful double-strand-break initiation and repair. Here we show that EWSR1, a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8627ac57d9a136fa7a99fd5e798af2
https://doi.org/10.1091/mbc.e20-09-0604
https://doi.org/10.1091/mbc.e20-09-0604
Autor:
Natalie R Powers, Emil D Parvanov, Christopher L Baker, Michael Walker, Petko M Petkov, Kenneth Paigen
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006146 (2016)
In many mammals, including humans and mice, the zinc finger histone methyltransferase PRDM9 performs the first step in meiotic recombination by specifying the locations of hotspots, the sites of genetic recombination. PRDM9 binds to DNA at hotspots t
Externí odkaz:
https://doaj.org/article/ef39fb2063b4469d869565c64bbbe09d
Autor:
Christopher L Baker, Pavlina Petkova, Michael Walker, Petr Flachs, Ondrej Mihola, Zdenek Trachtulec, Petko M Petkov, Kenneth Paigen
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005512 (2015)
Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination of deleterious alleles, and helps assure proper segregation of chromatids. Mammalian recombination events are concentrated at specialized sites, termed
Externí odkaz:
https://doaj.org/article/9d4cabb3f38d426994cbdbc5144ef1d2