Zobrazeno 1 - 10
of 1 006
pro vyhledávání: '"M, Peek"'
Autor:
Kasey M. Schalich, Matthew A. Buendia, Harpreet Kaur, Yash A. Choksi, M. Kay Washington, Gabriela S. Codreanu, Stacy D. Sherrod, John A. McLean, Richard M. Peek, Jr., Sari A. Acra, Steven D. Townsend, Fang Yan
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTObservational evidence suggests that human milk oligosaccharides (HMOs) promote the growth of commensal bacteria in early life and adulthood. However, the mechanisms by which HMOs benefit health through modulation of gut microbial homeostasis
Externí odkaz:
https://doaj.org/article/b1067dced790480e8612a3e92377e026
Autor:
Courtney Lunger, Zeli Shen, Hilda Holcombe, Anthony J. Mannion, JoAnn Dzink-Fox, Susanna Kurnick, Yan Feng, Sureshkumar Muthupalani, Sebastian E. Carrasco, Keith T. Wilson, Richard M. Peek, M. Blanca Piazuelo, Douglas R. Morgan, Amanda L. Armijo, Melissa Mammoliti, Timothy C. Wang, James G. Fox
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Helicobacter pylori (H. pylori) causes a cascade from gastritis to gastric neoplasia. During the chronic stages, the oncogenic transcription factor forkhead box protein M1 (FOXM1) becomes increasingly expressed. Given certain strains of the
Externí odkaz:
https://doaj.org/article/0cc4e0cdd03c4002a30d01f014dbcd22
Autor:
Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTHelicobacter pylori-induced inflammation is the strongest known risk factor for gastric adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of immunity and carcinogenesis. To examine the role of this mediat
Externí odkaz:
https://doaj.org/article/5ca1554c76e54c8382886b3806ff21b3
Autor:
Harpreet Kaur, Syed Azmal Ali, Sarah P. Short, Christopher S. Williams, Jeremy A. Goettel, M. Kay Washington, Richard M. Peek, Sari A. Acra, Fang Yan
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTSeveral probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is ori
Externí odkaz:
https://doaj.org/article/fbd498869d1e4dc9a38573f75067729d
Northern hemisphere ungulates occupy a variety of habitats of varying degrees of permanency. Populations that occupy drier areas must contend with different moisture patterns between years, but vegetation is relatively permanent, pending large-scale
Autor:
Samuel D.R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Chronic mucosal pathogens have evolved multiple strategies to manipulate the host immune response; consequently, microbes contribute to the development of >2 million cases of cancer/year. Gastric adenocarcinoma is the fourth leading cause of cancer-r
Externí odkaz:
https://doaj.org/article/f93259ca2dbb4a9897baa17e0061a47a
Autor:
Manikandan Palrasu, Elena Zaika, Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Giovanni Suarez, Jianwen Que, Wael El-Rifai, Richard M Peek, Monica Garcia-Buitrago, Alexander I Zaika
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010628 (2022)
Helicobacter pylori (H. pylori) is a common gastric pathogen that infects approximately half of the world's population. Infection with H. pylori can lead to diverse pathological conditions, including chronic gastritis, peptic ulcer disease, and cance
Externí odkaz:
https://doaj.org/article/254554bc69014a03868de78e3a912605
Autor:
Yilin Deng, Oliver G. McDonald, Anna L. Means, Richard M. Peek, Jr., M. Kay Washington, Sari A. Acra, D. Brent Polk, Fang Yan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1327-1345 (2021)
Background & Aims: Colonization by gut microbiota in early life confers beneficial effects on immunity throughout the host’s lifespan. We sought to elucidate the mechanisms whereby neonatal supplementation with p40, a probiotic functional factor, r
Externí odkaz:
https://doaj.org/article/c9d8505ae2364be6b0977cbd4b2e1b5b
Autor:
Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek Jr.
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host, and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in INS-GAS mice under iron-deficient conditions. Mechanistically, thes
Externí odkaz:
https://doaj.org/article/7d198f5f9fa7400583ab84388b9c0680
Autor:
Zeli Shen, JoAnn Dzink-Fox, Yan Feng, Sureshkumar Muthupalani, Anthony J. Mannion, Alexander Sheh, Mark T. Whary, Hilda R. Holcombe, Blanca M. Piazuelo, Luis E. Bravo, Christine Josenhans, Sebastian Suerbaum, Keith T. Wilson, Richard M. Peek, Timothy C. Wang, James G. Fox
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT In populations with similar prevalence of Helicobacter pylori infection, cancer risk can vary dramatically. Changes in composition or structure of bacterial communities in the stomach, either at the time of exposure or over the course of H.
Externí odkaz:
https://doaj.org/article/9e55ff19818544809735685cec27b446