Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin:A Metgen Meta-Analysis

Autor: T, Dujic, K, Zhou, S W, Yee, N, van Leeuwen, C E, de Keyser, M, Javorský, S, Goswami, L, Zaharenko, M M, Hougaard Christensen, M, Out, R, Tavendale, M, Kubo, M M, Hedderson, A A, van der Heijden, L, Klimčáková, V, Pirags, A, Kooy, K, Brøsen, J, Klovins, S, Semiz, I, Tkáč, B H, Stricker, Cna, Palmer, L M, 't Hart, K M, Giacomini, E R, Pearson

Publikováno v: Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Hougaard Christensen, M M, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A Metgen Meta-Analysis ', Clinical Pharmacology and Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical Pharmacology and Therapeutics, 101(6), 763-772
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Christensen, M M H, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A MetGen Meta-Analysis ', Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical pharmacology and therapeutics, vol 101, iss 6
Clinical Pharmacology & Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics

Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b762e525da754cb923dd8b91cd06ac1f
https://research.vumc.nl/en/publications/508fedaf-498a-4e2d-91a9-f7fedd97684b

Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K

Autor: J N, Commandeur, I, Andreadou, M, Rooseboom, M, Out, L J, de Leur, E, Groot, N P, Vermeulen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 294(2)

Selenocysteine Se-conjugates have recently been proposed as potential prodrugs to target pharmacologically active selenol compounds to the kidney. Although rat renal cytosol displayed a high activity of beta-elimination activity toward these substrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2420ebaff7138fb55eac55d19b792b1c
https://pubmed.ncbi.nlm.nih.gov/10900257

Phenotypic heterogeneity in cultured skin fibroblasts from patients with disorders of peroxisome biogenesis belonging to the same complementation group

Autor: M Out, H. van den Bosch, Ruud B.H. Schutgens, Ronald J.A. Wanders, Erik A.C. Wiemer, A. Schelen, Joseph M. Tager

Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1097(3), 232-237. Elsevier

We have studied fibroblast cell lines derived from a control subject (cell line 85AD5035F) and three patients clinically described as having the Zellweger syndrome (cell line W78/515), the infantile form of Refsum disease (cell line BOV84AD) and hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa2c3e99257015ab853124c884d8f9a
https://pure.amc.nl/en/publications/phenotypic-heterogeneity-in-cultured-skin-fibroblasts-from-patients-with-disorders-of-peroxisome-biogenesis-belonging-to-the-same-complementation-group(4be71576-2eca-4825-9171-ed039fbfcc8c).html

Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K.

Autor: N, Commandeur J, I, Andreadou, M, Rooseboom, M, Out, J, de Leur L, E, Groot, P, Vermeulen N

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; August 2000, Vol. 294 Issue: 2 p753-61, 9p

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