Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism

Autor: M Oosterga, Hendrik Buikema, Wiek H. van Gilst, Adriaan A. Voors, Peter Paul van Geel, Dirk J. van Veldhuisen

Publikováno v: Journal of the Renin-Angiotensin-Aldosterone System, Vol 5 (2004)

Introduction The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554c486c315d242471757bdfd37bd1e5
https://doi.org/10.3317/jraas.2004.029

Dual pathway for angiotensin II formation in human internal mammary arteries

Autor: Adriaan A. Voors, Hendrik Buikema, Yigal M. Pinto, Wiek H. van Gilst, M Oosterga, Gerrit Rooks, Hidenori Urata, Jan G. Grandjean, Detlev Ganten

Publikováno v: British Journal of Pharmacology. 125:1028-1032

1. Angiotensin converting enzyme (ACE) is thought to be the main enzyme to convert antiotensin I to the vasoactive angiotensin II. Recently, in the human heart, it was found that the majority of angiotensin II formation was due to another enzyme, ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a0b8442bbbd9ef91c1b9083dd5a6f38
https://doi.org/10.1038/sj.bjp.0702150

Abstracts of papers and posters Clinical Pharmacological Meeting

Autor: J. H. G. Jonkman, M. E. L. van der Burg, Th. Thien, A. J. M. Meulendijk, J. Bongaard van den Born, W. Bakker, N. G. M. Schipper, Frans W. H. M. Merkus, S. G. Romeijn, H. Van Belle, M. T. Esselink, D. J. Touw, J. A. Leusink, G. A. Rongen, R. Janknegt, K. Zech, G. Stoter, H. J. Guchelaar, H. Buikema, R. Huber, M. Kool, P. F. M. Kuks, E. Vellenga, M. de Boer-Dennert, J. W. M. Lenders, B. Steffens, L. E. Visser, E. G. E. de Vries, P. G. G. Gerlag, P. A. Van Zwieten, A.H. De Boer, Arijan J. Porsius, L. J. Bras, H. A. J. Struijker Boudier, B. M. de Jonah, H. A. Tissot van Patot, M. Doornbos, H. S. Lau, W. H. Van Gilst, T. A. Bruning, A. J. M. Loonen, John Verhoef, C. A. Verhagen, C. Meijer, J. J. Kraaijenga, A. K. S. van Musscher, A. Bakker, C. D. J. de Langen, P. H. M. van der Kuy, B. H. Ch. Stricker, J. Verweij, K. Ver Donck, P. A. M. Peeters, P.A. de Graeff, Jo Hermans, B. M. de Jongh, A. H. P. Paes, M. Hartmann, T. Dormans, J. H. M. Schellens, M. H. Steurs, D. de Boer, J. G. Grandiean, H. G. M. Heijerman, A. A. T. M. M. Vinks, M. Oosterga, J. J. H. Thijssen, J. Ma, G. Th. J. Fabius, H. Mattie, A. Hoeks, E. van Strijen, Harry Wesseling, P. Smits, J. van der Velden, J. Spek, D. R. A. Uges, A. S. T. Planting, J. J. M. van Mevel, C. H. Doorschot, B. Oosterhuis, P. C. Chang, M. H. A. Engberink, L. Van Bortel, N. H. Mulder

Publikováno v: Pharmacy World & Science. 15:1-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed5dd47ff9317399f54bc6bb80ec2a79
https://doi.org/10.1007/bf01875092

High angiotensin II responsiveness is associated with decreased endothelium-dependent relaxation in human arteries

Autor: M Oosterga, Adriaan A. Voors, Dirk J. van Veldhuisen, Peter Paul van Geel, Wiek H. van Gilst, Hendrik Buikema

Publikováno v: Journal of the Renin-Angiotensin-Aldosterone System, 6(3), 145-150
Journal of the Renin-Angiotensin-Aldosterone System, Vol 6 (2005)

Introduction. Animal studies demonstrated an interaction between angiotensin II (Ang II) responsiveness and endothelium-dependent relaxation (EDR). However, this relation has not been well described in humans. Therefore, we investigated the relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e97bf02a9288a0f3731572dab10c1e0
https://pubmed.ncbi.nlm.nih.gov/16525945

Differences between angiotensin-converting enzyme inhibition and angiotensin II-AT(1) antagonism on angiotensin-mediated responses in human internal mammary arteries

Autor: M Oosterga, Adriaan A. Voors, JG Grandjean, Massimo A. Mariani, Hendrik Buikema, WH van Glist

Publikováno v: Journal of Cardiovascular Pharmacology, 41(2), 178-184

The current study aimed to demonstrate differences between angiotensin (Ang)-converting enzyme (ACE) inhibition and Ang II-AT1 receptor antagonism on full concentration-contraction responses to Ang I. Contraction responses to increasing concentration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0ba367e5773c18c15fcba18e8db768
https://research.rug.nl/en/publications/60b36de7-cfce-42a4-8155-9e08751f2148