Zobrazeno 1 - 10
of 9 631
pro vyhledávání: '"M, O'Brien"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Disparities in surgical outcomes often result from subjective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative i
Externí odkaz:
https://doaj.org/article/6f39856aaa204a0482520d8308ce1820
Autor:
Brett M. O’Brien, Roumita Moulick, Gabriel Jiménez-Avalos, Nandakumar Rajasekaran, Christian M. Kaiser, Sarah A. Woodson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract In Huntington’s Disease (HD) and related disorders, expansion of CAG trinucleotide repeats produces a toxic gain of function in affected neurons. Expanded huntingtin (expHTT) mRNA forms aggregates that sequester essential RNA binding prote
Externí odkaz:
https://doaj.org/article/d3eef5568a5f480c8bb43f557a076f30
Autor:
Bingxin Zhao, Yujue Li, Zirui Fan, Zhenyi Wu, Juan Shu, Xiaochen Yang, Yilin Yang, Xifeng Wang, Bingxuan Li, Xiyao Wang, Carlos Copana, Yue Yang, Jinjie Lin, Yun Li, Jason L. Stein, Joan M. O’Brien, Tengfei Li, Hongtu Zhu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The retina, an anatomical extension of the brain, forms physiological connections with the visual cortex of the brain. Although retinal structures offer a unique opportunity to assess brain disorders, their relationship to brain structure an
Externí odkaz:
https://doaj.org/article/a163f6c74dfd413d8ed67238f1b00521
Autor:
Md Sohel Ahmed, Brenda J. Hanley, Corey I. Mitchell, Rachel C. Abbott, Nicholas A. Hollingshead, James G. Booth, Joe Guinness, Christopher S. Jennelle, Florian H. Hodel, Carlos Gonzalez-Crespo, Christopher R. Middaugh, Jennifer R. Ballard, Bambi Clemons, Charlie H. Killmaster, Tyler M. Harms, Joe N. Caudell, Kathryn M. Benavidez Westrich, Emily McCallen, Christine Casey, Lindsey M. O’Brien, Jonathan K. Trudeau, Chad Stewart, Michelle Carstensen, William T. McKinley, Kevin P. Hynes, Ashley E. Stevens, Landon A. Miller, Merril Cook, Ryan T. Myers, Jonathan Shaw, Michael J. Tonkovich, James D. Kelly, Daniel M. Grove, Daniel J. Storm, Krysten L. Schuler
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Continued spread of chronic wasting disease (CWD) through wild cervid herds negatively impacts populations, erodes wildlife conservation, drains resource dollars, and challenges wildlife management agencies. Risk factors for CWD have been in
Externí odkaz:
https://doaj.org/article/da63780f247e444897414988daded37d
Publikováno v:
Systematic Reviews, Vol 13, Iss 1, Pp 1-9 (2024)
Abstract Background Frailty reduction and reversal have been addressed successfully among older populations within community settings. However, these findings may not be applicable to residential care settings, largely due to the complex and multidim
Externí odkaz:
https://doaj.org/article/a6aeafa07dbe49c889028ab5c356007c
Autor:
Ann Von Holle, Min Shi, Katie M. O'Brien, Clarice R. Weinberg, Dale P. Sandler, Yong-Moon Mark Park
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
A better understanding of the factors contributing to systemic concentrations of carotenoids is necessary given the weak correlations between circulating levels and dietary intake of carotenoids. Although genetic variation may play a key role in the
Externí odkaz:
https://doaj.org/article/c0cbb2c9c38243c0bdf8a95b6746b9ef
Autor:
Tamara Matthyssen, Wenyi Li, James A. Holden, Jason C. Lenzo, Sara Hadjigol, Neil M. O’Brien-Simpson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionMelittin is a potent antimicrobial peptide from bee venom that is effective against both Gram-positive and Gram-negative bacteria. However, it is extremely toxic to mammalian cells and, as yet, has no clinical use. Modifications to its am
Externí odkaz:
https://doaj.org/article/81af5452720b48978a8b1731c22bac4e
Autor:
Mazyar Shadman, Alessandra Tedeschi, Leyla Mohseninejad, Keri Yang, Nicole Lamanna, Sheng Xu, Aileen Cohen, Swetha Challagulla, Mei Xue, Rhys Williams, Susan M. O’Brien, Jennifer R. Brown, Constantine Tam
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/e548c73b0c6d4a53b356797818e0367a
Autor:
Jie Ping, Guochong Jia, Qiuyin Cai, Xingyi Guo, Ran Tao, Christine Ambrosone, Dezheng Huo, Stefan Ambs, Mollie E. Barnard, Yu Chen, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Esther M. John, Christopher I. Li, Katherine Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Toshio Yoshimatsu, Prisca O. Adejumo, Thomas Ahearn, Abenaa M. Brewster, Anselm J. M. Hennis, Timothy Makumbi, Paul Ndom, Katie M. O’Brien, Andrew F. Olshan, Mojisola M. Oluwasanu, Sonya Reid, Song Yao, Ebonee N. Butler, Maosheng Huang, Atara Ntekim, Bingshan Li, Melissa A. Troester, Julie R. Palmer, Christopher A. Haiman, Jirong Long, Wei Zheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susceptibility genes. We built geneti
Externí odkaz:
https://doaj.org/article/b9834eb3a0344dc2a7b7b629b0f35afc
Autor:
N. Lange, B. Fiedler, M. Álvarez, A. Benoit-Cattin, H. Benway, P. L. Buttigieg, L. Coppola, K. Currie, S. Flecha, D. S. Gerlach, M. Honda, I. E. Huertas, S. K. Lauvset, F. Muller-Karger, A. Körtzinger, K. M. O'Brien, S. R. Ólafsdóttir, F. C. Pacheco, D. Rueda-Roa, I. Skjelvan, M. Wakita, A. White, T. Tanhua
Publikováno v:
Earth System Science Data, Vol 16, Pp 1901-1931 (2024)
The presented pilot for the Synthesis Product for Ocean Time Series (SPOTS) includes data from 12 fixed ship-based time-series programs. The related stations represent unique open-ocean and coastal marine environments within the Atlantic Ocean, Pacif
Externí odkaz:
https://doaj.org/article/6eb15aeecabe42dcb96d3c08d867b503