Zobrazeno 1 - 10
of 571
pro vyhledávání: '"M, Nicolae"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Replication stress compromises genomic integrity. Fork blocking lesions such as those induced by cisplatin and other chemotherapeutic agents arrest replication forks. Repriming downstream of these lesions represents an important mechanism of
Externí odkaz:
https://doaj.org/article/91581a74d5184f80833b47a45c7b283a
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA tumor suppressor pathway
Externí odkaz:
https://doaj.org/article/fd6a77a2b70d4ad48b428ac71575a32e
Autor:
Tanay Thakar, Ashna Dhoonmoon, Joshua Straka, Emily M. Schleicher, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Efficient DNA replication is crucial for genome stability. Here, Thakar et al. report that accumulation of lagging strand ssDNA gaps during replication interferes with nucleosome assembly and drives replication fork degradation in BRCA-deficient cell
Externí odkaz:
https://doaj.org/article/2dd4e50ca1d340f4ae9cf8bf31f43a9d
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Protection of replication forks against nucleolytic degradation is crucial for genome stability. Here, Dhoonmoon et al identify PARP14 and the KU complex as essential regulators of fork degradation by MRE11 and EXO1 nucleases in BRCA-deficient cells.
Externí odkaz:
https://doaj.org/article/fcffd21913bc45bdb2ca47c3e609a412
Autor:
Emily M. Schleicher, Ashna Dhoonmoon, Lindsey M. Jackson, Jude B. Khatib, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Maintenance of replication fork stability is essential for genome preservation. Stalled replication forks can be reversed by translocases such as SMARCAL1, and unless protected through the activity of the BRCA pathway, are subsequently subje
Externí odkaz:
https://doaj.org/article/62ab80586c0647d183275c406a41f42c
Autor:
Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase pro
Externí odkaz:
https://doaj.org/article/dd9a83371d84474f8a570030b092cfce
Autor:
Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong-Gang Wang, Subhajyoti De, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout an
Externí odkaz:
https://doaj.org/article/bbee1b004cdc4bdebae2ddc9b6d5a3f3
Autor:
Tanay Thakar, Wendy Leung, Claudia M. Nicolae, Kristen E. Clements, Binghui Shen, Anja-Katrin Bielinsky, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PCNA is essential for DNA replication and cellular proliferation. Here, the authors reveal that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation via regulation of Okazaki fragment maturation and chromatin assembly
Externí odkaz:
https://doaj.org/article/83d73c42ce554d03b39eb16def8e823b
Autor:
Bassam Abu-Libdeh, Satpal S. Jhujh, Srijita Dhar, Joshua A. Sommers, Arindam Datta, Gabriel M.C. Longo, Laura J. Grange, John J. Reynolds, Sophie L. Cooke, Gavin S. McNee, Robert Hollingworth, Beth L. Woodward, Anil N. Ganesh, Stephen J. Smerdon, Claudia M. Nicolae, Karina Durlacher-Betzer, Vered Molho-Pessach, Abdulsalam Abu-Libdeh, Vardiella Meiner, George-Lucian Moldovan, Vassilis Roukos, Tamar Harel, Robert M. Brosh Jr., Grant S. Stewart
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ family of helicases, mutations in RECQL1 have not been
Externí odkaz:
https://doaj.org/article/e82e799461ca42b1a71605c628f57492
Publikováno v:
International Journal of Cardiology Congenital Heart Disease, Vol 3, Iss , Pp 100096- (2021)
Background: Heart failure within the adult congenital heart disease (ACHD) population is a significant source of morbidity and mortality. Optimal medical therapy (OMT) remains the mainstay of management for ACHD heart failure patients. Sacubitril/Val
Externí odkaz:
https://doaj.org/article/2d69a9dc81434716a7a3d414bef250d0