Zobrazeno 1 - 10
of 2 362
pro vyhledávání: '"M, NOBLE"'
Autor:
Christopher Hurst, Lorelle Dismore, Antoneta Granic, Jane M. Noble, Susan J. Hillman, Miles D. Witham, Avan A. Sayer, Richard M. Dodds, Sian M. Robinson
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Older adults living with multiple long-term conditions (MLTC, also known as multimorbidity) and frailty are more likely to experience a deterioration in their health requiring specialist referral or hospital admission than individ
Externí odkaz:
https://doaj.org/article/d54c4629cb40484faec61335f53f3504
Autor:
Rhianna J. Rowland, Svitlana Korolchuk, Marco Salamina, Natalie J. Tatum, James R. Ault, Sam Hart, Johan P. Turkenburg, James N. Blaza, Martin E. M. Noble, Jane A. Endicott
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we present the cryo-EM structure of CDK2-cycli
Externí odkaz:
https://doaj.org/article/7f9036edb0fb4c63978dfd51fe5e5873
Autor:
Heather Davies, Goran Nenadic, Ghada Alfattni, Mercedes Arguello Casteleiro, Noura Al Moubayed, Sean Farrell, Alan D. Radford, P.-J. M. Noble
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
In part two of this mini-series, we evaluate the range of machine-learning tools now available for application to veterinary clinical text-mining. These tools will be vital to automate extraction of information from large datasets of veterinary clini
Externí odkaz:
https://doaj.org/article/9cc7f140cf32400ea3ae65442e3e74eb
Autor:
Emily H. Xiong, Xiang Zhang, Huijuan Yan, Henry N. Ward, Zhen-Yuan Lin, Cassandra J. Wong, Ci Fu, Anne-Claude Gingras, Suzanne M. Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114601- (2024)
Summary: Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the therapeutic target space is to identify genes important for pathogen growth in host-rele
Externí odkaz:
https://doaj.org/article/7a90d14f55eb4540a12239260d52e408
Autor:
Elena Arsevska, Tomislav Hengl, David A. Singleton, Peter-John M. Noble, Cyril Caminade, Obiora A. Eneanya, Philip H. Jones, Jolyon M. Medlock, Kayleigh M. Hansford, Carmelo Bonannella, Alan D. Radford
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background Ticks are an important driver of veterinary health care, causing irritation and sometimes infection to their hosts. We explored epidemiological and geo-referenced data from > 7 million electronic health records (EHRs) from cats an
Externí odkaz:
https://doaj.org/article/112f17ac6463498592d885ef736a1f3c
Autor:
Stephanie Doering, Austin McCullough, Brian A. Gordon, Charles D. Chen, Nicole McKay, Diana Hobbs, Sarah Keefe, Shaney Flores, Jalen Scott, Hunter Smith, Stephen Jarman, Kelley Jackson, Russ C. Hornbeck, Beau M. Ances, Chengjie Xiong, Andrew J. Aschenbrenner, Jason Hassenstab, Carlos Cruchaga, Alisha Daniels, Randall J. Bateman, John C. Morris, Tammie L.S. Benzinger, James M. Noble, Gregory S. Day, Neill R. Graff-Radford, Jonathan Voglein, Johannes Levin, Ricardo F. Allegri, Patricio Chrem Mendez, Ezequiel Surace, Sarah B. Berman, Snezana Ikonomovic, Neelesh K. Nadkarni, Francisco Lopera, Laura Ramirez, David Aguillon, Yudy Leon, Claudia Ramos, Diana Alzate, Ana Baena, Natalia Londono, Sonia Moreno, Mathias Jucker, Christoph Laske, Elke Kuder-Buletta, Susanne Graber-Sultan, Oliver Preische, Anna Hofmann, Takeshi Ikeuchi, Kensaku Kasuga, Yoshiki Niimi, Kenji Ishii, Michio Senda, Raquel Sanchez-Valle, Pedro Rosa-Neto, Nick C. Fox, Dave Cash, Jae-Hong Lee, Jee Hoon Roh, Stephen Salloway, Meghan C. Riddle, William Menard, Courtney Bodge, Mustafa Surti, Leonel Tadao Takada, Martin Farlow, Jasmeer P. Chhatwal, V.J. Sanchez-Gonzalez, Maribel Orozco-Barajas, Alison M. Goate, Alan E. Renton, Bianca T. Esposito, Celeste M. Karch, Jacob Marsh, Victoria Fernanadez, Anne M. Fagan, Gina Jerome, Elizabeth Herries, Jorge Llibre-Guerra, Allan I. Levey, Erik C.B. Johnson, Nicholas T. Seyfried, Peter R. Schofield, William S. Brooks, Jacob A. Bechara, Randall Bateman, Eric McDade, Richard J. Perrin, Erin E. Franklin, Tammie Benzinger, Allison Chen, Charles Chen, Nelly Friedrichsen, Brian Gordon, Nancy Hantler, Russ Hornbeck, Steve Jarman, Deborah Koudelis, Parinaz Massoumzadeh, Joyce Nicklaus, Christine Pulizos, Qing Wang, Sheetal Mishall, Edita Sabaredzovic, Emily Deng, Madison Candela, Peter Wang, Xiong Xu, Yan Li, Emily Gremminger, Yinjiao Ma, Ryan Bui, Ruijin Lu, Ralph Martins, Ana Luisa Sosa Ortiz, Laura Courtney, Hiroshi Mori, Charlene Supnet-Bell, Jinbin Xu, John Ringman, Nicolas Barthelemy, John Morris, Jennifer Smith
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105080- (2024)
Summary: Background: Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in which tau spreads to additional brain regio
Externí odkaz:
https://doaj.org/article/0b7b8db8958a47c9b99946f7b5107ddb
Publikováno v:
Cognitive Research, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract In a dynamic decision-making task simulating basic ship movements, participants attempted, through a series of actions, to elicit and identify which one of six other ships was exhibiting either of two hostile behaviors. A high-performing, al
Externí odkaz:
https://doaj.org/article/a80d9144dac84fa6883dfc0292554d47
Autor:
Christopher Hurst, Lorelle Dismore, Antoneta Granic, Ellen Tullo, Jane M. Noble, Susan J. Hillman, Miles D. Witham, Avan A. Sayer, Richard M. Dodds, Sian M. Robinson
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Many older adults live with the combination of multiple long-term conditions (MLTC) and frailty and are at increased risk of a deterioration in health requiring interaction with healthcare services. Low skeletal muscle strength is
Externí odkaz:
https://doaj.org/article/6eb04b2fd0cf43d1a12cb52a63db4204
Autor:
Derek J. Bays, Hannah P. Savage, Connor Tiffany, Mariela A. F. Gonzalez, Eli. J. Bejarano, Henry Nguyen, Hugo L. P. Masson, Thaynara P. Carvalho, Renato L. Santos, Andrew Tritt, Suzanne M. Noble, George R. Thompson, Andreas J. Bäumler
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 119-120 (2024)
OBJECTIVES/GOALS: Antibiotic treatment sets the stage for intestinal domination by Candida albicanswhich is necessary for development of invasive disease, but the resources driving this bloom remain poorly defined. We sought to determine these factor
Externí odkaz:
https://doaj.org/article/f42c016a9b9e44799468b8b12fad880a
Autor:
Zhongle Liu, Pauline Basso, Saif Hossain, Sean D. Liston, Nicole Robbins, Luke Whitesell, Suzanne M. Noble, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Metabolic flexibility enables fungi to invade challenging host environments. In Candida albicans, a common cause of life-threatening infections in humans, an important contributor to flexibility is alternative oxidase (Aox) activity. Dramati
Externí odkaz:
https://doaj.org/article/77916211e1fb435cbbda60aadd78443d