Zobrazeno 1 - 10
of 112
pro vyhledávání: '"M, Morrisey"'
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Cholesterol is the most abundant lipid in the erythrocyte. During its blood-stage development, the malaria parasite establishes an active cholesterol gradient across the various membrane systems within the infected erythrocyte. Interestingly
Externí odkaz:
https://doaj.org/article/0b241a990575494fbc37d3cb8ddfd151
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
The mitochondrion of malaria parasites is an attractive antimalarial drug target, which require mitoribosomes to translate genes encoded in the mitochondrial (mt) DNA. Plasmodium mitoribosomes are composed of highly fragmented ribosomal RNA (rRNA) en
Externí odkaz:
https://doaj.org/article/d2faef078f2c499ca011d340c220803d
Autor:
Hangjun Ke, Suresh M Ganesan, Swati Dass, Joanne M Morrisey, Sovitj Pou, Aaron Nilsen, Michael K Riscoe, Michael W Mather, Akhil B Vaidya
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214023 (2019)
The battle against malaria has been substantially impeded by the recurrence of drug resistance in Plasmodium falciparum, the deadliest human malaria parasite. To counter the problem, novel antimalarial drugs are urgently needed, especially those that
Externí odkaz:
https://doaj.org/article/93b12d83f6f74bde8f392ab58d0b99ea
Autor:
Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinás, Akhil B. Vaidya
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 164-174 (2015)
New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials. Herein, we describe 11 genetic knockout (
Externí odkaz:
https://doaj.org/article/390244a769ff4f8298d6fdfe1c5ed3c0
The malaria parasites encode all eight mitochondrial enzymes that can constitute the classical tricarboxylic acid (TCA) cycle. We previously reported that genetic ablation of six out of eight TCA enzymes had no significant impact on the parasite surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732849c59782339ff4fdf0910f1d110a
https://doi.org/10.1101/2022.08.05.502965
https://doi.org/10.1101/2022.08.05.502965
Autor:
Sudipta Das, Suyash Bhatanagar, Joanne M Morrisey, Thomas M Daly, James M Burns, Isabelle Coppens, Akhil B Vaidya
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005647 (2016)
Among the several new antimalarials discovered over the past decade are at least three clinical candidate drugs, each with a distinct chemical structure, that disrupt Na+ homeostasis resulting in a rapid increase in intracellular Na+ concentration ([
Externí odkaz:
https://doaj.org/article/34132c11ef42427098742ad90d4c36a6
Autor:
Bethany J Jenkins, Thomas M Daly, Joanne M Morrisey, Michael W Mather, Akhil B Vaidya, Lawrence W Bergman
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152197 (2016)
Coenzyme Q (CoQ, ubiquinone) is a central electron carrier in mitochondrial respiration. CoQ is synthesized through multiple steps involving a number of different enzymes. The prevailing view that the CoQ used in respiration exists as a free pool tha
Externí odkaz:
https://doaj.org/article/2d4f7a9080ec4dcc9717e57ae56a768f
Cholesterol is the most abundant lipid in the erythrocyte. During its blood stage development, the malaria parasite establishes an active cholesterol gradient across the various membrane systems within the infected erythrocyte. Interestingly, some an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c1ba600b4accf3ca023c75d4d5db71
https://doi.org/10.1101/2021.10.06.463412
https://doi.org/10.1101/2021.10.06.463412
Publikováno v:
ACS Infectious Diseases. 5:550-558
Lipid homeostasis is essential for the maintenance of life. We previously reported that disruptions of the parasite Na+ homeostasis via inhibition of PfATP4 resulted in elevated cholesterol within the parasite plasma membrane as assessed by saponin s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3f7f49d816bd79dfadee63a98ea5b2
https://doi.org/10.1021/acsinfecdis.8b00277
https://doi.org/10.1021/acsinfecdis.8b00277
Autor:
Joanne M. Morrisey, Heather J. Painter, Michael K. Riscoe, Akhil B. Vaidya, Lindsey M. Orchard, Martin J. Smilkstein, Cuyler Luck, Manuel Llinás, Michael W. Mather
Publikováno v:
Antimicrob Agents Chemother
The continued emergence of drug-resistant Plasmodium falciparum parasites hinders global attempts to eradicate malaria, emphasizing the need to identify new antimalarial drugs. Attractive targets for chemotherapeutic intervention are the cytochrome (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2134fb34e873ec0be9f1870d826345d
https://doi.org/10.1128/aac.02143-20
https://doi.org/10.1128/aac.02143-20