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Akademický článek

Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures

Publikováno v: iScience, Vol 26, Iss 10, Pp 107830- (2023)

Summary: Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines and treatments against this threat are urgently needed. Here, we have refined our previously established model of

Externí odkaz: https://doaj.org/article/64d9ec9d91b942c4adacf65285a4edf8

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Akademický článek

The role of the dentist in the diagnosis and management of pediatric obstructive sleep apnea

Autor: Hafiz M. Moin Anwer, Hamad N. Albagieh, Mythili Kalladka, Harmeet K. Chiang, Shaima Malik, Sean W. McLaren, Junad Khan

Publikováno v: Saudi Dental Journal, Vol 33, Iss 7, Pp 424-433 (2021)

The objective of this article is to review the role of the dentist in the early diagnosis of pediatric obstructive sleep apnea (OSA) and to provide an in-depth review of the best evidence-based practices available to treat and/or to refer these patie

Externí odkaz: https://doaj.org/article/cb5f65f0400045af8eafc9290bec8f45

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Akademický článek

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Akademický článek

Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

Autor: Seyhan Boyoglu-Barnum, Geoffrey B. Hutchinson, Jeffrey C. Boyington, Syed M. Moin, Rebecca A. Gillespie, Yaroslav Tsybovsky, Tyler Stephens, John R. Vaile, Julia Lederhofer, Kizzmekia S. Corbett, Brian E. Fisher, Hadi M. Yassine, Sarah F. Andrews, Michelle C. Crank, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Influenza virus hemagglutinin (HA) stem between group 1 and 2 viruses has different glycosylation patterns, likely hampering cross-group protection. Here, Boyoglu-Barnum et al. show that introducing a group 2 glycan into a group 1 stem nanoparticle v

Externí odkaz: https://doaj.org/article/341c5ca3cd954a0f92613862f3db746e

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Akademický článek

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Akademický článek

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

Autor: Daiyin Tian, Michael B. Battles, Syed M. Moin, Man Chen, Kayvon Modjarrad, Azad Kumar, Masaru Kanekiyo, Kevin W. Graepel, Noor M. Taher, Anne L. Hotard, Martin L. Moore, Min Zhao, Zi-Zheng Zheng, Ning-Shao Xia, Jason S. McLellan, Barney S. Graham

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)

Monoclonal antibodies to prevent respiratory syncytial virus (RSV) disease are under development, but the molecular requirements for cross-subtype neutralization are unclear. Here, the authors show that residue 201 in RSV fusion protein determines su

Externí odkaz: https://doaj.org/article/72a5be0f154c45639beb660fdd77aff7

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Akademický článek

A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from R

Externí odkaz: https://doaj.org/article/2a61be93aec04ad3a0b22213856c0d55

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Akademický článek

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

Publikováno v: mBio, Vol 10, Iss 1 (2019)

ABSTRACT Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. While HA stem-based

Externí odkaz: https://doaj.org/article/cd997d727dab4f9a9bff7e2660bf416f

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