Zobrazeno 1 - 10
of 509
pro vyhledávání: '"M, McNutt"'
Autor:
Mostafa Rezapour, Stephen J. Walker, David A. Ornelles, Muhammad Khalid Khan Niazi, Patrick M. McNutt, Anthony Atala, Metin Nafi Gurcan
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
In this study, we delved into the comparative analysis of gene expression data across RNA-Seq and NanoString platforms. While RNA-Seq covered 19,671 genes and NanoString targeted 773 genes associated with immune responses to viruses, our primary focu
Externí odkaz:
https://doaj.org/article/45e6291e6e7c4df7995fbfbb6fe5d8ed
Autor:
Mostafa Rezapour, Stephen J. Walker, David A. Ornelles, Patrick M. McNutt, Anthony Atala, Metin Nafi Gurcan
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionOur study undertakes a detailed exploration of gene expression dynamics within human lung organ tissue equivalents (OTEs) in response to Influenza A virus (IAV), Human metapneumovirus (MPV), and Parainfluenza virus type 3 (PIV3) infection
Externí odkaz:
https://doaj.org/article/3aa893f9eca64910900f5de919545a0d
Autor:
Mostafa Rezapour, Stephen J Walker, David A Ornelles, Muhammad Khalid Khan Niazi, Patrick M McNutt, Anthony Atala, Metin Nafi Gurcan
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0308849 (2024)
In this study, we used a three-dimensional airway "organ tissue equivalent" (OTE) model at an air-liquid interface (ALI) to mimic human airways. We investigated the effects of three viruses (Influenza A virus (IAV), Human metapneumovirus (MPV), and P
Externí odkaz:
https://doaj.org/article/308150fa600a48188075b2c549fc01f9
Autor:
James B. Machamer, Edwin J. Vazquez-Cintron, Mallory J. Stenslik, Kathleen T. Pagarigan, Aaron B. Bradford, Celinia A. Ondeck, Patrick M. McNutt
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionBotulinum neurotoxin (BoNT) causes neuroparalytic disease and death by blocking neuromuscular transmission. There are no specific therapies for clinical botulism and the only treatment option is supportive care until neuromuscular functio
Externí odkaz:
https://doaj.org/article/8a9f93deb0aa4fd4ad7ec9376ca356fa
Autor:
Jean Mukherjee, Celinia A. Ondeck, Jacqueline M. Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H. Erasmus, Patrick M. McNutt, Charles B. Shoemaker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Single domain antibodies (sdAbs), also called nanobodies, have substantial biophysical advantages over conventional antibodies and are increasingly being employed as components of immunotherapeutic agents. One particularly favorable property
Externí odkaz:
https://doaj.org/article/fbf6a19e8929440a86eeb6f344288f44
Autor:
James B. Machamer, Edwin J. Vazquez-Cintron, Sean W. O’Brien, Kyle E. Kelly, Amber C. Altvater, Kathleen T. Pagarigan, Parker B. Dubee, Celinia A. Ondeck, Patrick M. McNutt
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-14 (2022)
Abstract Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis and death by asphyxiation. Other than post-exposure prophylaxis with antitoxin, the
Externí odkaz:
https://doaj.org/article/217f4bf70c89403a831545108d977f5c
Autor:
P. Sonaimuthu, E. Senkevitch, N. Haskins, P. Uapinyoying, M. McNutt, H. Morizono, M. Tuchman, L. Caldovic
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The urea cycle protects the central nervous system from ammonia toxicity by converting ammonia to urea. N-acetylglutamate synthase (NAGS) catalyzes formation of N-acetylglutamate, an essential allosteric activator of carbamylphosphate synthe
Externí odkaz:
https://doaj.org/article/3cb4d09c378b4a00b4053cca1e4add5d
Autor:
Kwok-ho Lam, Jacqueline M. Tremblay, Edwin Vazquez-Cintron, Kay Perry, Celinia Ondeck, Robert P. Webb, Patrick M. McNutt, Charles B. Shoemaker, Rongsheng Jin
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2526-2539.e6 (2020)
Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of
Externí odkaz:
https://doaj.org/article/9b97bbbb254f433e82a523d6039fe9be
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse B
Externí odkaz:
https://doaj.org/article/96fff58717034b729ab96d902fc0e129
Publikováno v:
Proceedings of the 2023 CHI Conference on Human Factors in Computing Systems.
AI-powered code assistants, such as Copilot, are quickly becoming a ubiquitous component of contemporary coding contexts. Among these environments, computational notebooks, such as Jupyter, are of particular interest as they provide rich interface af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc835c90d203c1e1da1131d64a53674c
https://doi.org/10.1145/3544548.3580940
https://doi.org/10.1145/3544548.3580940