Zobrazeno 1 - 10
of 598
pro vyhledávání: '"M, McFadden"'
Autor:
Anna T. Gres, Karen A. Kirby, William M. McFadden, Haijuan Du, Dandan Liu, Chaoyi Xu, Alexander J. Bryer, Juan R. Perilla, Jiong Shi, Christopher Aiken, Xiaofeng Fu, Peijun Zhang, Ashwanth C. Francis, Gregory B. Melikyan, Stefan G. Sarafianos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract HIV-1 capsid (CA) stability is important for viral replication. E45A and P38A mutations enhance and reduce core stability, thus impairing infectivity. Second-site mutations R132T and T216I rescue infectivity. Capsid lattice stability was stu
Externí odkaz:
https://doaj.org/article/6fc3ded6264445bc83e52d0bb630d90c
Autor:
Ahmed Nahian, Lisa M. McFadden
Publikováno v:
Healthcare, Vol 12, Iss 16, p 1630 (2024)
As drug overdose mortality rises in the United States, healthcare visits present critical opportunities to mitigate this trend. This study examines changes in healthcare visits for substance use disorders (SUDs) and remission prior to and during the
Externí odkaz:
https://doaj.org/article/7e56d84cf9d94054bfdafed02344bcf4
Autor:
Lauren J. Donoghue, Kathryn M. McFadden, Daniel Vargas, Gregory J. Smith, Robert M. Immormino, Timothy P. Moran, Samir N. P. Kelada
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Among asthmatics, there is significant heterogeneity in the clinical presentation and underlying pathophysiological mechanisms, leading to the recognition of multiple disease endotypes (e.g., T2-high vs. T2-low). This heterogeneity extends t
Externí odkaz:
https://doaj.org/article/9b49a06e33fb4b67bf91cd7b9abd38cc
Autor:
Thamina Akther, William M. McFadden, Huanchun Zhang, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3734 (2024)
HIV-1 capsid protein (CA) is the molecular target of the recently FDA-approved long acting injectable (LAI) drug lenacapavir (GS-6207). The quick emergence of CA mutations resistant to GS-6207 necessitates the design and synthesis of novel sub-chemot
Externí odkaz:
https://doaj.org/article/068a84c45998479f94c11f3be6504359
Autor:
Marie A Severson, Sathaporn Onanong, Alexandra Dolezal, Shannon L Bartelt-Hunt, Daniel D Snow, Lisa M McFadden
Publikováno v:
JMIR Formative Research, Vol 7, p e45353 (2023)
BackgroundSubstance use disorder and associated deaths have increased in the United States, but methods for detecting and monitoring substance use using rapid and unbiased techniques are lacking. Wastewater-based surveillance is a cost-effective meth
Externí odkaz:
https://doaj.org/article/7c67c2f19d824aaca526a210d3d46883
Autor:
Nour J. Youssef, Nadim K. Tfaily, Mohammad Bahij M. Moumneh, Celina F. Boutros, Jad A. Elharake, Amyn A. Malik, SarahAnn M. McFadden, Bayan Galal, Inci Yildirim, Kaveh Khoshnood, Saad B. Omer, Ziad A. Memish, Ghassan S. Dbaibo
Publikováno v:
Journal of Epidemiology and Global Health, Vol 13, Iss 1, Pp 55-66 (2023)
Abstract Background Lebanon endured its worst economic and financial crisis in 2020–2021. To minimize the impact of COVID-19 pandemic, it is important to improve the overall COVID-19 vaccination rate. Given that vaccine hesitancy among health care
Externí odkaz:
https://doaj.org/article/bc03b263cea84e99a477c28e101118ea
Changes in buprenorphine visits in frontier and remote locations: Effects of the SARS-CoV-2 pandemic
Autor:
Lisa M. McFadden
Publikováno v:
Drug and Alcohol Dependence Reports, Vol 7, Iss , Pp 100155- (2023)
Background: The pandemic has changed many aspects of healthcare, including the treatment of people with opioid use disorder with buprenorphine. Prior to the pandemic, rural health disparities existed in the accessibility of this treatment. Rural and
Externí odkaz:
https://doaj.org/article/cbce205d861b443b879068b4aa9a868c
Autor:
William M. McFadden, Alexa A. Snyder, Karen A. Kirby, Philip R. Tedbury, Monika Raj, Zhengqiang Wang, Stefan G. Sarafianos
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract The capsid core of HIV-1 is a large macromolecular assembly that surrounds the viral genome and is an essential component of the infectious virus. In addition to its multiple roles throughout the viral life cycle, the capsid interacts with m
Externí odkaz:
https://doaj.org/article/643d8e60442642368bed50228dfd80e6
Publikováno v:
JMIR Formative Research, Vol 6, Iss 10, p e40215 (2022)
BackgroundCOVID-19 has caused nearly 1 million deaths in the United States, not to mention job losses, business and school closures, stay-at-home orders, and mask mandates. Many people have suffered increased anxiety and depression since the pandemic
Externí odkaz:
https://doaj.org/article/16d346b17f0346f595cba3945ffe5d3c
Autor:
Jad A. Elharake, MPH, Bayan Galal, Saleh A. Alqahtani, MD, Rana F. Kattan, MD, MME, Mazin A. Barry, MD, Mohamad-Hani Temsah, MD, Amyn A. Malik, MBBS, MPH, PhD, SarahAnn M. McFadden, PhD, RN, CPN, Inci Yildirim, MD, PhD, MSc, Kaveh Khoshnood, PhD, Saad B. Omer, MBBS, MPH, PhD, FIDSA, Ziad A. Memish, MD, FACP, FRCPC, FRCPE, FIDSA
Publikováno v:
International Journal of Infectious Diseases, Vol 109, Iss , Pp 286-293 (2021)
Objectives: The purpose of our study was to assess COVID-19 vaccine acceptance among health care workers (HCWs) in the Kingdom of Saudi Arabia (KSA) and identify: 1) vaccine acceptance barriers; 2) demographic differences; and 3) the most trusted COV
Externí odkaz:
https://doaj.org/article/5e53cf79d0af4be5b7960e89b6e9bd92