Zobrazeno 1 - 10
of 541
pro vyhledávání: '"M, McEwen"'
Autor:
Andres Cardenas, Simone Ecker, Raj P. Fadadu, Karen Huen, Allan Orozco, Lisa M. McEwen, Hannah-Ruth Engelbrecht, Nicole Gladish, Michael S. Kobor, Luis Rosero-Bixby, William H. Dow, David H. Rehkopf
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated smoking-associated DN
Externí odkaz:
https://doaj.org/article/b2b46d2a69af4ea997a822e4c5b2ab3a
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Advanced glycation end-products (AGEs), such as methylglyoxal-derived hydroimidazolone isomer (MGH-1), are associated with disease and age-related disorders, and occur spontaneously, so it is unclear why specific protein sites become modified with sp
Externí odkaz:
https://doaj.org/article/5fba806714964ba4b997f252adebc342
Autor:
M. McEwen, D. Kafri, Z. Chen, J. Atalaya, K. J. Satzinger, C. Quintana, P. V. Klimov, D. Sank, C. Gidney, A. G. Fowler, F. Arute, K. Arya, B. Buckley, B. Burkett, N. Bushnell, B. Chiaro, R. Collins, S. Demura, A. Dunsworth, C. Erickson, B. Foxen, M. Giustina, T. Huang, S. Hong, E. Jeffrey, S. Kim, K. Kechedzhi, F. Kostritsa, P. Laptev, A. Megrant, X. Mi, J. Mutus, O. Naaman, M. Neeley, C. Neill, M. Niu, A. Paler, N. Redd, P. Roushan, T. C. White, J. Yao, P. Yeh, A. Zalcman, Yu Chen, V. N. Smelyanskiy, John M. Martinis, H. Neven, J. Kelly, A. N. Korotkov, A. G. Petukhov, R. Barends
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Correlated errors coming from leakage out of the computational subspace are an obstacle to fault-tolerant superconducting circuits. Here, the authors use a multi-level reset protocol to improve the performances of a bit-flip error correcting code by
Externí odkaz:
https://doaj.org/article/ef5bee6bb56f44459aef65280dc80df5
Autor:
Shantala A. Hari Dass, Kathryn McCracken, Irina Pokhvisneva, Lawrence M. Chen, Elika Garg, Thao T.T. Nguyen, Zihan Wang, Barbara Barth, Moein Yaqubi, Lisa M. McEwen, Julie L. MacIsaac, Josie Diorio, Michael S. Kobor, Kieran J. O'Donnell, Michael J. Meaney, Patricia P. Silveira
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 188-202 (2019)
Background: Activation of brain insulin receptors modulates reward sensitivity, inhibitory control and memory. Variations in the functioning of this mechanism likely associate with individual differences in the risk for related mental disorders (atte
Externí odkaz:
https://doaj.org/article/0a930b227bbe495788b5d17b8ed4a14e
Autor:
Lucas T. Husquin, Maxime Rotival, Maud Fagny, Hélène Quach, Nora Zidane, Lisa M. McEwen, Julia L. MacIsaac, Michael S. Kobor, Hugues Aschard, Etienne Patin, Lluis Quintana-Murci
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background DNA methylation is influenced by both environmental and genetic factors and is increasingly thought to affect variation in complex traits and diseases. Yet, the extent of ancestry-related differences in DNA methylation, their gene
Externí odkaz:
https://doaj.org/article/743757f00ca14b97969e29f1ebd85894
Autor:
Kimberly A Dill-McFarland, Stephan G König, Florent Mazel, David C Oliver, Lisa M McEwen, Kris Y Hong, Steven J Hallam
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008661 (2021)
We live in an increasingly data-driven world, where high-throughput sequencing and mass spectrometry platforms are transforming biology into an information science. This has shifted major challenges in biological research from data generation and pro
Externí odkaz:
https://doaj.org/article/91a092c34a58441093d9b6106110d016
Autor:
B. Chiaro, C. Neill, A. Bohrdt, M. Filippone, F. Arute, K. Arya, R. Babbush, D. Bacon, J. Bardin, R. Barends, S. Boixo, D. Buell, B. Burkett, Y. Chen, Z. Chen, R. Collins, A. Dunsworth, E. Farhi, A. Fowler, B. Foxen, C. Gidney, M. Giustina, M. Harrigan, T. Huang, S. Isakov, E. Jeffrey, Z. Jiang, D. Kafri, K. Kechedzhi, J. Kelly, P. Klimov, A. Korotkov, F. Kostritsa, D. Landhuis, E. Lucero, J. McClean, X. Mi, A. Megrant, M. Mohseni, J. Mutus, M. McEwen, O. Naaman, M. Neeley, M. Niu, A. Petukhov, C. Quintana, N. Rubin, D. Sank, K. Satzinger, T. White, Z. Yao, P. Yeh, A. Zalcman, V. Smelyanskiy, H. Neven, S. Gopalakrishnan, D. Abanin, M. Knap, J. Martinis, P. Roushan
Publikováno v:
Physical Review Research, Vol 4, Iss 1, p 013148 (2022)
The interplay of interactions and strong disorder can lead to an exotic quantum many-body localized (MBL) phase of matter. Beyond the absence of transport, the MBL phase has distinctive signatures, such as slow dephasing and logarithmic entanglement
Externí odkaz:
https://doaj.org/article/9730720d85f1446e9d010b56c4aee4a2
Autor:
Lisa M McEwen, Meaghan J Jones, David Tse Shen Lin, Rachel D Edgar, Lucas T Husquin, Julia L MacIsaac, Katia E Ramadori, Alexander M Morin, Christopher F Rider, Chris Carlsten, Lluís Quintana-Murci, Steve Horvath, Michael S Kobor
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods. The most commonly used DNAm microarray, the Illumina Infinium HumanMethylation450 (450K a
Externí odkaz:
https://doaj.org/article/c7c9511d89d7403dbd78d2c6ae04b322
Autor:
Lawrence M. Chen, Nelson Yao, Elika Garg, Yuecai Zhu, Thao T. T. Nguyen, Irina Pokhvisneva, Shantala A. Hari Dass, Eva Unternaehrer, Hélène Gaudreau, Marie Forest, Lisa M. McEwen, Julia L. MacIsaac, Michael S. Kobor, Celia M. T. Greenwood, Patricia P. Silveira, Michael J. Meaney, Kieran J. O’Donnell
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background Polygenic risk scores (PRS) describe the genomic contribution to complex phenotypes and consistently account for a larger proportion of variance in outcome than single nucleotide polymorphisms (SNPs) alone. However, there is littl
Externí odkaz:
https://doaj.org/article/d52bb4756a324b0787c6192331339009
Autor:
Khadijah Breathett, Erika Yee, Natalie Pool, Megan Hebdon, Janice D. Crist, Shannon Knapp, Ashley Larsen, Sade Solola, Luis Luy, Kathryn Herrera‐Theut, Leanne Zabala, Jeff Stone, Marylyn M. McEwen, Elizabeth Calhoun, Nancy K. Sweitzer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 22 (2019)
Background Race influences medical decision making, but its impact on advanced heart failure therapy allocation is unknown. We sought to determine whether patient race influences allocation of advanced heart failure therapies. Methods and Results Mem
Externí odkaz:
https://doaj.org/article/841366ac99814eaeb2186079e59553b8