Murine macrophage-based iNos reporter reveals polarization and reprogramming in the context of breast cancer

Autor: Javier A. Mas-Rosario, Josue D. Medor, Mary I. Jeffway, José M. Martínez-Montes, Michelle E. Farkas

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

As part of the first line of defense against pathogens, macrophages possess the ability to differentiate into divergent phenotypes with varying functions. The process by which these cells change their characteristics, commonly referred to as macropha

Externí odkaz: https://doaj.org/article/511d117ebd5d4c5bbb0a72058248865e

Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas

Autor: Dieter M. Matlac, Katerina Hadrava Vanova, Nicole Bechmann, Susan Richter, Julica Folberth, Hans K. Ghayee, Guang-Bo Ge, Luma Abunimer, Robert Wesley, Redouane Aherrahrou, Margo Dona, Ángel M. Martínez-Montes, Bruna Calsina, Maria J. Merino, Markus Schwaninger, Peter M. T. Deen, Zhengping Zhuang, Jiri Neuzil, Karel Pacak, Hendrik Lehnert, Stephanie M. J. Fliedner

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative. However, complete resection may not be an option for patients with succinate dehydrogenas

Externí odkaz: https://doaj.org/article/341f1888ed96433699e71d363cd1e7e4

Using genome wide association studies to identify common QTL regions in three different genetic backgrounds based on Iberian pig breed.

Autor: Ángel M Martínez-Montes, Almudena Fernández, María Muñoz, Jose Luis Noguera, Josep M Folch, Ana I Fernández

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0190184 (2018)

One of the major limitation for the application of QTL results in pig breeding and QTN identification has been the limited number of QTL effects validated in different animal material. The aim of the current work was to validate QTL regions through j

Externí odkaz: https://doaj.org/article/a7520434d5e44dbb8b49f4339754339d

Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome

Autor: Luis J Leandro-García, Guillermo Velasco, Bruna Calsina, Georgia Anguera, Pablo Maroto, Rocío Letón, Maria José Santos, María Monteagudo, Ángel M Martínez-Montes, Eduardo Caleiras, Jesús García-Donas, Cristina Rodríguez-Antona, Cristina Montero-Conde, Alberto Cascón, Javier Lanillos, Mercedes Robledo, Juan María Roldan-Romero

Publikováno v: MODERN PATHOLOGY
r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Chromophobe renal cell carcinoma (chRCC) is a histologically and molecularly distinct class of rare renal tumor. TCGA studies revealed low mutational burden, with only TP53 and PTEN recurrently mutated, and discovered alterations in TERT promoter and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a50154d9d97b395a18bd54a21f25602
https://doi.org/10.1038/s41379-020-0607-z

Analysis of Telomere Maintenance Related Genes Reveals

Autor: María, Monteagudo, Paula, Martínez, Luis J, Leandro-García, Ángel M, Martínez-Montes, Bruna, Calsina, Marta, Pulgarín-Alfaro, Alberto, Díaz-Talavera, Sara, Mellid, Rocío, Letón, Eduardo, Gil, Manuel, Pérez-Martínez, Diego, Megías, Raúl, Torres-Ruiz, Sandra, Rodriguez-Perales, Patricia, González, Eduardo, Caleiras, Scherezade, Jiménez-Villa, Giovanna, Roncador, Cristina, Álvarez-Escolá, Rita M, Regojo, María, Calatayud, Sonsoles, Guadalix, Maria, Currás-Freixes, Elena, Rapizzi, Letizia, Canu, Svenja, Nölting, Hanna, Remde, Martin, Fassnacht, Nicole, Bechmann, Graeme, Eisenhofer, Massimo, Mannelli, Felix, Beuschlein, Marcus, Quinkler, Cristina, Rodríguez-Antona, Alberto, Cascón, María A, Blasco, Cristina, Montero-Conde, Mercedes, Robledo

Publikováno v: Cancers

Simple Summary Telomere maintenance involving TERT and ATRX genes has been recently described in metastatic pheochromocytoma and paraganglioma, reinforcing the importance of immortalization mechanisms in the progression of these tumors. Thus, the aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3cbdd71ec8e5c0a30682935649ce2d4e
https://pubmed.ncbi.nlm.nih.gov/34638246