Zobrazeno 1 - 10
of 1 088
pro vyhledávání: '"M, Macfarlane"'
Autor:
James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Zackery T. Knauss, Albert Dahan, Jason A. Bubier, Peter M. MacFarlane, Devin Mueller, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract N-acetyl-L-cysteine (L-NAC) is a proposed therapeutic for opioid use disorder. This study determined whether co-injections of L-NAC (500 μmol/kg, IV) or its highly cell-penetrant analogue, L-NAC methyl ester (L-NACme, 500 μmol/kg, IV), pre
Externí odkaz:
https://doaj.org/article/7cf134f1aa4b40f786d4d28221785b6e
Autor:
Paulina M. Getsy, Gregory A. Coffee, James N. Bates, Theodore Parran, Lee Hoffer, Santhosh M. Baby, Peter M. MacFarlane, Zackery T. Knauss, Derek S. Damron, Yee-Hsee Hsieh, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The ability of morphine to decrease cysteine transport into neurons by inhibition of excitatory amino acid transporter 3 (EAA3) may be a key molecular mechanism underlying the acquisition of physical and psychological dependence to morphine. This stu
Externí odkaz:
https://doaj.org/article/25505fc3abd147f1bfb54bb923d7270b
Autor:
Ashley Petersen, Elena R Fisher, Deborah Cragun, Robert F Dedrick, Crystal Y Lumpkins, Mariana Ramírez, Kimberly A Kaphingst, Ian M MacFarlane, Krista Redlinger-Grosse, Abdirashid Shire, Kathleen A Culhane-Pera, Heather A Zierhut
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction In over 50 years since the genetic counseling (GC) profession began, a systematic study of GC communication skills and patient-reported outcomes in actual sessions across multiple clinical specialties has never been conducted. To optimiz
Externí odkaz:
https://doaj.org/article/32a08628e9514be6b580bfb9b301030a
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse
Externí odkaz:
https://doaj.org/article/5ab96a619e0f445aae20d91926abf672
Publikováno v:
BMC Primary Care, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract In their paper “Challenges with international medical graduate selection: finding positive attributes predictive of success in family medicine residency,” (BMC Prim Care 23(256):2–9, 2022) the authors report on their research into qual
Externí odkaz:
https://doaj.org/article/c65b948fa20b4952899eaf04f98f9cbd
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The o
Externí odkaz:
https://doaj.org/article/d549c8fe16774f9597f7ae5c9d895bb5
Autor:
Anantha Harijith, Prathima Basa, Alison Ha, Jaya Thomas, Anjum Jafri, Panfeng Fu, Peter M. MacFarlane, Thomas M. Raffay, Viswanathan Natarajan, Tara Sudhadevi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Management of acute respiratory distress involves O2 supplementation, which is lifesaving, but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a major source of reactive oxygen species (ROS) in hyperoxia (HO). Epithelia
Externí odkaz:
https://doaj.org/article/f3ccbd489032403689598d814f9f2df6
Autor:
Malcolm M MacFarlane
Publikováno v:
Canadian Medical Education Journal, Vol 12, Iss 4 (2021)
This paper explores the marginalization experienced by International Medical Graduates (IMGs) in the Canadian Residency Matching Service (CaRMS) Match. This marginalization occurs despite all IMGs being Canadian citizens or permanent residents, and h
Externí odkaz:
https://doaj.org/article/75874cd962d94f5bb95243032d0580a9
Autor:
Anne M. Roesler, Jovanka Ravix, Colleen M. Bartman, Brijeshkumar S. Patel, Marta Schiliro, Benjamin Roos, Lisa Nesbitt, Christina M. Pabelick, Richard J. Martin, Peter M. MacFarlane, Y. S. Prakash
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Supplemental O2 (hyperoxia), necessary for maintenance of oxygenation in premature infants, contributes to neonatal and pediatric airway diseases including asthma. Airway smooth muscle (ASM) is a key resident cell type, responding to hyperoxia with i
Externí odkaz:
https://doaj.org/article/5535a7aeff7046d5bb61a44eac067e3e
Autor:
Erin M. MacFarlane, Jennifer E. Bruin
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Diabetes prevalence is increasing worldwide, and epidemiological studies report an association between diabetes incidence and environmental pollutant exposure. There are >84,000 chemicals in commerce, many of which are released into the environment w
Externí odkaz:
https://doaj.org/article/b47b7ee341e3482ea2394c4d7d4e6da4