Výsledky vyhledávání

Drug sensitivity prediction with normal inverse Gaussian shrinkage informed by external data

Autor: Magnus M. Münch, Mark A. van de Wiel, Sylvia Richardson, Gwenaël G. R. Leday

Publikováno v: Biometrical Journal. Biometrische Zeitschrift
Münch, MM, van de Wiel, MA, Richardson, S & Leday, G G R 2021, ' Drug sensitivity prediction with normal inverse Gaussian shrinkage informed by external data ', Biometrical Journal, vol. 63, no. 2, pp. 289-304 . https://doi.org/10.1002/bimj.201900371, https://doi.org/10.1002/bimj.201900371
Biometrical Journal, 63(2), 289-304. Wiley-VCH Verlag

In precision medicine, a common problem is drug sensitivity prediction from cancer tissue cell lines. These types of problems entail modelling multivariate drug responses on high-dimensional molecular feature sets in typically >1000 cell lines. The d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf136702cd83d4e6fdc04ecc7ecb9cf
https://doi.org/10.1002/bimj.201900371

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Adaptive group-regularized logistic elastic net regression

Autor: Magnus M. Münch, Mark A. van de Wiel, Carel F.W. Peeters, Aad van der Vaart

Publikováno v: Münch, MM, Peeters, CFW, van der Vaart, AW & van de Wiel, MA 2019, ' Adaptive group-regularized logistic elastic net regression ', Biostatistics .
Biostatistics (Oxford, England) 22 (2021) 4
Biostatistics. Oxford University Press
Biostatistics (Oxford, England)
Biostatistics (Oxford, England), 22(4), 723-737

In high-dimensional data settings, additional information on the features is often available. Examples of such external information in omics research are: (a) p-values from a previous study, (b) a summary of prior information, and (c) omics annotatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995c51fbc14528774af35f837fa6459f
https://doi.org/10.1093/biostatistics/kxz062

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O042 Sleep’s relationship with mood and loneliness among working women during New Zealand’s COVID-19 lockdown

Autor: M Helles, R Fletcher, M Münch, R Gibson

Publikováno v: SLEEP Advances. 3:A17-A18

Background The COVID-19 lockdown enforced unique limitations on social and working life. Changes to sleep and mood have been reported with mixed results, possibly related to measuring such outcomes between populations and social contexts. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5567b593270477dfea1876f5a5e11973
https://doi.org/10.1093/sleepadvances/zpac029.041

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Biomechanical aspects of the posteromedial split in bicondylar tibial plateau fractures—a finite-element investigation

Autor: T. Barth, J. Dehoust, M. Münch, Karl-Heinz Frosch, K. Seide

Publikováno v: European Journal of Trauma and Emergency Surgery. 46:1257-1266

To gain principal insight into fixation techniques of a posteromedial split fragment in bicondylar tibial plateau fractures. A computer simulation was performed, applying the finite-element method (FEM) to compare four methods of fixation of the post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d46987af8095646058a70c65788e5e00
https://doi.org/10.1007/s00068-020-01538-3

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