Zobrazeno 1 - 10
of 427
pro vyhledávání: '"M, Lifshitz"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Maintenance of fecal continence requires a continuous or basal tone of the internal anal sphincter (IAS). Paradoxically, the basal tone results largely from high-frequency rhythmic contractions of the IAS smooth muscle. However, the cellular
Externí odkaz:
https://doaj.org/article/ebf0d9b536e34d8c85847111097d8e4c
Autor:
Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M Harney, Chloe DiMarzio, Hui Wang, Nicholas McHugh, Brianna Bramato, Brett Morrison, Jeffery D Rothstein, Anastasia Khvorova, Michael P Czech
Publikováno v:
eLife, Vol 12 (2024)
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice reportedly pro
Externí odkaz:
https://doaj.org/article/874400b9307a469685643153d134f013
Autor:
Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)
Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a
Externí odkaz:
https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337
Autor:
Emmanouela Tsagkaraki, Sarah M. Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Lawrence M. Lifshitz, Yuefei Shen, Mark Kelly, Adilson Guilherme, Felipe Henriques, Nadia Amrani, Raed Ibraheim, Tomas C. Rodriguez, Kevin Luk, Stacy Maitland, Randall H. Friedline, Lauren Tauer, Xiaodi Hu, Jason K. Kim, Scot A. Wolfe, Erik J. Sontheimer, Silvia Corvera, Michael P. Czech
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mi
Externí odkaz:
https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db0
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure. The tissue injury and repair hypothesis for adenomyosis suggests that uterine hyperperistalsis or dysperistalsis plays a pivotal role in establishing adenomyoti
Externí odkaz:
https://doaj.org/article/cb5ede8cc3dd45728c0519cc0bc54de4
Autor:
Felipe Henriques, Alexander H. Bedard, Adilson Guilherme, Mark Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl Bellvé, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Lee S. Weinstein, Jiandie D. Lin, Paul Cohen, Michael P. Czech
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107998- (2020)
Summary: Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregul
Externí odkaz:
https://doaj.org/article/54696ef0102c4411a50554f01eb35a76
Autor:
Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M. Harney, Chloe DiMarzio, Nicholas McHugh, Brianna Bramato, Brett Morrision, Jeffery D. Rothstein, Anastasia Khvorova, Michael P. Czech
Publikováno v:
bioRxiv
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice reportedly pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d17fb05a9946b358bc61bcf3cbd9710
https://europepmc.org/articles/PMC10187148/
https://europepmc.org/articles/PMC10187148/
Akademický článek
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Autor:
Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type
Externí odkaz:
https://doaj.org/article/b4b7ab0c59cd416bb5911aec0550d29f
Autor:
Yetao Wang, Lawrence M Lifshitz, Noah Silverstein, Esther Mintzer, Kevin Luk, Pamela StLouis, Michael Brehm, Scot A. Wolfe, Steven Deeks, Jeremy Luban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49018c860e96a6b9cfdbe3dc2fcce53e
https://doi.org/10.15252/rc.2023978741
https://doi.org/10.15252/rc.2023978741