Zobrazeno 1 - 10
of 1 133
pro vyhledávání: '"M, Levinson"'
Autor:
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, Silvia Toledo Ramos, David D Thomas, William CK Pomerantz, Tanya S Freedman, Nicholas M Levinson
Publikováno v:
eLife, Vol 13 (2024)
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why activation rather than inhibition occurs remains unclear. Using
Externí odkaz:
https://doaj.org/article/908aea3f4eb7430b8ef82e94417a536d
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract This study creates a historic dataset of road opening dates in Sydney. A method was developed for map digitization to extract spatial data from historic maps and place them in a collective vector layer. The method includes extensive georefer
Externí odkaz:
https://doaj.org/article/e05010daa764441cb43f78fbe323321a
Autor:
Erik B. Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Nan Wang, Damien Rasmussen, Abir Majumdar, Laura E. Hirsch, Kristen John, An Yang, Hira Khalid, Jon E. Hawkinson, Nicholas M. Levinson, Vargheese Chennathukuzhi, Daniel A. Harki, Ernst Schönbrunn, Gunda I. Georg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the often observed lower structural similarity at these distal sites. Despite their promise, rel
Externí odkaz:
https://doaj.org/article/43490103b21742f1887f75facd34c438
The Pentateuch lies at the heart of the Western humanities. Yet despite nearly two centuries of scholarship, its historical origins and its literary history are still a subject of intense discussion. Critical scholarship has isolated multiple layers
Autor:
William L. Garrison, David M. Levinson
The Transportation Experience explores the historical evolution of transportation modes and technologies. The book traces how systems are innovated, planned and adapted, deployed and expanded, and reach maturity, where they may either be maintained i
Autor:
Bernard M. Levinson
The historical-critical method that characterizes academic biblical studies too often remains separate from approaches that stress the history of interpretation, which are employed more frequently in the area of Second Temple or Dead Sea Scrolls rese
Autor:
N. Tavernier, Y. Thomas, S. Vigneron, P. Maisonneuve, S. Orlicky, P. Mader, S. G. Regmi, L. Van Hove, N. M. Levinson, G. Gasmi-Seabrook, N. Joly, M. Poteau, G. Velez-Aguilera, O. Gavet, A. Castro, M. Dasso, T. Lorca, F. Sicheri, L. Pintard
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Tavernier et al. decipher the mechanism by which the intrinsically disordered protein Bora, phosphorylated by Cyclin-Cdk, potentiates AURKA activity towards Polo-like kinase 1. Furthermore, they demonstrate the importance of this mechanism for timely
Externí odkaz:
https://doaj.org/article/c85f4e856295480db1bc7aa81205cfc6
Publikováno v:
Findings (2022)
This study estimates a panel regression model to predict bicyclist route choice. Using GPS trajectories of 600 trips from 49 participants in spring 2006 in Minneapolis, we calculate deviation, the average distance between alternative routes and actua
Externí odkaz:
https://doaj.org/article/90b0dadaa4c24228a0a21c864d091101
Publikováno v:
Transportation Research Interdisciplinary Perspectives, Vol 13, Iss , Pp 100536- (2022)
In urban planning and design, a holistic perspective is needed to examine multiple potential scenarios in future developing plans. Access (or accessibility) is a concept that measures the performance of a city in terms of how easily residents can rea
Externí odkaz:
https://doaj.org/article/9db1391a7689444ebfd75d97636dcd75