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Akademický článek
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Autor:
M. Lebl, Wayne L. Cody, Ana Maria de Lauro Castrucci, M. E. Hadley, Brian C. Wilkes, Victor J. Hruby
Publikováno v:
International Journal of Peptide and Protein Research. 24:472-479
The highly potent cyclic analogue of alpha-MSH, Ac-[Cys4,Cys10]-alpha-MSH4-13-NH2, was structurally modified in position 4. Four analogues were prepared and their biological activities in the in vitro frog and lizard skin bioassays were determined. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f16ef3a0176949759123ef0940407cf0
https://doi.org/10.1111/j.1399-3011.1984.tb03147.x
https://doi.org/10.1111/j.1399-3011.1984.tb03147.x
Publikováno v:
IEEE Sensors Journal. 7:506-514
This paper presents a neuromorphic approach for sensor-based machine olfaction that combines a portable chemical detection system based on microbead array technology with a biologically inspired model of signal processing in the olfactory bulb. The s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b3cdd1987fa5f7d8514e28ea96c698
https://doi.org/10.1109/jsen.2007.891935
https://doi.org/10.1109/jsen.2007.891935
Publikováno v:
Molecular Diversity. 1:177-182
A small-molecule synthetic combinatorial library was designed and synthesized that features potential pharmacophores attached to a variety of small cyclic scaffolds. The synthesis of the library involved randomization of three types of building block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c9b2154f40958ad752f1974d38b8ca
https://doi.org/10.1007/bf01544955
https://doi.org/10.1007/bf01544955
Autor:
M. Lebl, Viktor Krchňák, V. Pokorný, P. Mudra, M. Pavlı́k, K. Ženı́šek, Z. Barták, J. Kalousek, Sydney E. Salmon, Z. Vobůrka, J. Bolf, M. Rinnová, Kit S. Lam
Publikováno v:
Methods. 6:432-437
An automatic peptide library synthesizer capable of randomizing 20 building blocks in 20 reaction vessels is described. The design is based on uniform bead distribution by gravity sedimentation after thorough mixing by inert gas bubbling and stirring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87e0cb5b60af69515cfc8c044a7f9830
https://doi.org/10.1006/meth.1994.1046
https://doi.org/10.1006/meth.1994.1046
Autor:
M. Lebl, Kit S. Lam
Publikováno v:
Methods. 6:372-380
The Selectide process is a random synthetic chemical library method based on the one-bead one-peptide (structure) concept. A "split-synthesis" method is used to generate huge random libraries (10 6 -10 8 ). At the end of the synthesis, each bead expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa33abe5124868506c79f40e40b2e94a
https://doi.org/10.1006/meth.1994.1037
https://doi.org/10.1006/meth.1994.1037
Publikováno v:
Methods. 6:381-387
A method for the synthesis and screening of polymeric libraries for biologic activities in solution is described. Libraries are constructed on a completely random basis with one structure on one particle of solid support (bead). The screened structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe4abbc2552e4cb55b721b0cf889ab84
https://doi.org/10.1006/meth.1994.1038
https://doi.org/10.1006/meth.1994.1038
Publikováno v:
Drug Development Research. 33:146-156
A synthetic chemical library comprised of alkylated and acylated amino acids was synthesized and screened to determine structures that bind to a model target, streptavidin. The library was prepared using "split synthesis" and screened in a solid phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47de2834d0a77fd5d52fe80f587f090c
https://doi.org/10.1002/ddr.430330211
https://doi.org/10.1002/ddr.430330211
Publikováno v:
Drug Development Research. 33:157-160
Using a "one-bead one-peptide" rombinatorial peptide library method, we have been able to identify peptide ligands that interact specifically with various macromolecular targets such as monoclonal antibodies, streptavidin, avidin, MHC-Class I molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a77266765728839744b7b5a09cb94c
https://doi.org/10.1002/ddr.430330212
https://doi.org/10.1002/ddr.430330212