Výsledky vyhledávání

The dipeptidyl peptidase-4 inhibitor linagliptin lowers postprandial glucose and improves measures ofβ-cell function in type 2 diabetes

Autor: Hans-Juergen Woerle, Uwe Hehnke, M. Larbig, Klaus Dugi, Tim Heise, Thomas Seck, Sanjay Patel

Publikováno v: Diabetes, Obesity and Metabolism. 16:1036-1039

Progressive deterioration of pancreatic β-cell function in patients with type 2 diabetes mellitus (T2DM) contributes to worsening of hyperglycaemia. To investigate the effects of the dipeptidyl peptidase-4 inhibitor linagliptin on β-cell function p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c46061ac78bc4a2cae057e77a26ebe2
https://doi.org/10.1111/dom.12312

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Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions

Autor: Norbert Krug, Albrecht Bufe, R. van Ree, Jens M. Hohlfeld, M. Larbig, Martien L. Kapsenberg, Eddy A. Wierenga, M. Lavae-Mokhtari, T. Holland-Letz

Publikováno v: Clinical & Experimental Allergy. 40:998-1006

Summary Background Efficacy testing of drugs in seasonal allergic rhinitis (SAR) is often disturbed by seasonal variations of environmental allergens, and assessment of onset and duration of action is hardly possible under natural conditions. Allerge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5a86ed8e839f835253b5c4ef6a8c488
https://doi.org/10.1111/j.1365-2222.2010.03498.x

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Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial β-cell protection in individuals with type 2 diabetes

Autor: Thomas Forst, W. Roth, C. Hohberg, S Forst, M Larbig, A. Pfützner, S Diessel, M. Borchert

Publikováno v: Diabetes, Obesity & Metabolism

AIM Postprandial release of intact proinsulin (IP) is an independent marker for beta-cell dysfunction in patients with type 2 diabetes. This open-label, parallel-group, two-arm, pilot study compared the beta-cell protective effect of adding insulin g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6a9d2cabdc9803f89420a21051554d
https://doi.org/10.1111/j.1463-1326.2010.01209.x

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Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study

Autor: Andreas Fritsche, HU Häring, M. Larbig, David R. Owens

Publikováno v: Diabetes, Obesity and Metabolism. 12:115-123

Aim: To compare the efficacy and safety of an intensified insulin regimen, using insulin glargine (glargine) once daily and pre-meal insulin glulisine (glulisine) (basal-bolus), with a conventional therapy, using premixed insulin (premix) twice daily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9f700617cbf1846612beb6adb1bbac
https://doi.org/10.1111/j.1463-1326.2009.01165.x

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The Toll-Like Receptor-2/6 Agonist Macrophage-Activating Lipopeptide-2 Cooperates with IFN-γ to Reverse the Th2 Skew in an In Vitro Allergy Model

Autor: Armin Braun, Henning Weigt, Peter F. Mühlradt, Norbert Krug, M. Larbig

Publikováno v: The Journal of Immunology. 172:6080-6086

Dendritic cells (DC) are the most potent APCs with the capacity to induce, modulate, or shut down immune function. These features make them potentially useful for treating diseases associated with misled immunologic responses. Therefore, it was the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6e82704560f6f0aa8b93eb91892ffa
https://doi.org/10.4049/jimmunol.172.10.6080

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Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis

Autor: Wolfgang Koch, H. Loedding, Norbert Krug, Horst Windt, H. Geldmacher, Birgit Luettig, W. Behnke, Philipp Badorrek, A. Buckendahl, M. Larbig, Jens M. Hohlfeld, Wilhelm Dunkhorst

Publikováno v: Clinical & Experimental Allergy. 33:1667-1674

Summary Background There is an increasing need for allergen inhalation systems to perform basic clinical research and test anti-allergic drugs under well-controlled conditions. This requires stability of environmental conditions like temperature and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::263538972db84a0156686c931a853e7e
https://doi.org/10.1111/j.1365-2222.2003.01810.x

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Residual cftr Expression Varies with Age in cftrtm1Hgu Cystic Fibrosis Mice: Impact on Morphology and Physiology

Autor: S. Jansen, Ivo Steinmetz, Wolfgang Bernhard, J. R. Dorin, Thomas Tschernig, Hans-Jürgen Hedrich, M. Larbig, B. Bellmann, David J. Porteous, B. Tuemmler, H. von der Hardt, M. Dorsch

Publikováno v: Pathobiology. 70:89-97

Mouse models for cystic fibrosis (CF) mimic intestinal manifestations of the human disease, but the lung disease phenotypes are lacking in most strains. In this work, the issue was addressed whether aging of the respiratory tract leads to lung pathop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a35f77e1b90a3b89a0b31bbb77be200
https://doi.org/10.1159/000067308

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