Zobrazeno 1 - 10
of 80
pro vyhledávání: '"M, Kupchik"'
Publikováno v:
Neuropsychopharmacology
Cocaine use and abstinence induce long-term synaptic alterations in the excitatory input to nucleus accumbens (NAc) medium spiny neurons (MSNs). The NAc regulates reward-related behaviors through two parallel projections to the ventral pallidum (VP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e089597cd656b1a61375ee2363dd9b8e
https://doi.org/10.1038/s41386-022-01285-6
https://doi.org/10.1038/s41386-022-01285-6
Autor:
Shana Golden, Ramesh Chandra, Yonatan M. Kupchik, Gal Elyasaf, Mary Kay Lobo, Nimrod Bernat, Michel Engeln, Hyungwoo Nam, Mahashweta Basu, Seth A. Ament, Tal Odesser, Rianne Campbell
The ventral pallidum (VP) is central to reward seeking and withdrawal from drugs of abuse. A characteristic of the VP is the diversity of its projection targets. Yet, it remains unknown whether different VP projections also differ in other aspects, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c18989391fcc9d0cfe81a4223f7aa43
https://doi.org/10.1101/2021.11.15.468637
https://doi.org/10.1101/2021.11.15.468637
Autor:
Yonatan M. Kupchik, Asheeta A. Prasad
Publikováno v:
Neuroscience and biobehavioral reviews. 131
The ventral pallidum (VP) is central to the reinforcing effects across a variety of drugs and relapse to drug seeking. Emerging studies from animal models of reinstatement reveal a complex neurobiology of the VP that contributes to different aspects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9b28ad99a3aebfc477d5438ce7683e
https://pubmed.ncbi.nlm.nih.gov/34562544
https://pubmed.ncbi.nlm.nih.gov/34562544
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 111
Obesity is a growing global epidemic that stems from the increasing availability of highly-palatable foods and the consequent enhanced calorie consumption. Extensive research has shown that brain regions that are central to reward seeking modulate fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620d42f62e2821650a958d2e71a6d006
https://pubmed.ncbi.nlm.nih.gov/34242717
https://pubmed.ncbi.nlm.nih.gov/34242717
Publikováno v:
J Neurosci
A major driver of obesity is the increasing palatability of processed foods. Although reward circuits promote the consumption of palatable food, their involvement in obesity remains unclear. The ventral pallidum (VP) is a key hub in the reward system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b147ba59e622e8b1be7cc400a8de2518
https://pubmed.ncbi.nlm.nih.gov/33199503
https://pubmed.ncbi.nlm.nih.gov/33199503
Autor:
Gregory L. Powell, Cassandra D. Gipson, Ian A. Vicino, Mark D. Namba, Yonatan M. Kupchik, Constanza Garcia-Keller, Sade Spencer, Ian B. Hogue, Julianna Goenaga
Publikováno v:
Addict Biol
Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine-glutamate exchange protein xCT within the nucleus accumbens core (NAcore). N-acetylcysteine (NAC) has been shown to restor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c295c788091402fe72069bfbf6fa7233
https://doi.org/10.1111/adb.12797
https://doi.org/10.1111/adb.12797
Autor:
Yonatan M. Kupchik, Nimrod Bernat, Dorrit Inbar, Ava Gatterer, Kineret Inbar, Noa Nachshon, Liran A. Levi
Publikováno v:
J Neurosci
The ventral pallidum (VP) is a central node in the reward system that is strongly implicated in reward and addiction. Although the majority of VP neurons are GABAergic and encode reward, recent studies revealed a novel glutamatergic neuronal populati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59a4134a3487e377e0eedf75076eed7
https://pubmed.ncbi.nlm.nih.gov/32354855
https://pubmed.ncbi.nlm.nih.gov/32354855
Publikováno v:
J Neurosci
Cocaine-driven changes in the modulation of neurotransmission by neuromodulators are poorly understood. The ventral pallidum (VP) is a key structure in the reward system, in which GABA neurotransmission is regulated by opioid neuropeptides, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d17ef38408c4f1a66a378e10f945ca
https://pubmed.ncbi.nlm.nih.gov/31836660
https://pubmed.ncbi.nlm.nih.gov/31836660
Autor:
Peter W. Kalivas, Yonatan M. Kupchik, Jasper A. Heinsbroek, Ana-Clara Bobadilla, Daniela Neuhofer, William C. Griffin, Griffin S. Siegel
Publikováno v:
The Journal of Neuroscience. 37:757-767
Distinct populations of D1- and D2-dopamine receptor-expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, whereas activity in D2-MSNs inhibits, motivated behaviors. We used chemogenetics to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcab7a9dbeefd65c4b6ba4b6eba7dbd
https://doi.org/10.1523/jneurosci.2659-16.2016
https://doi.org/10.1523/jneurosci.2659-16.2016
Autor:
Alexander C.W. Smith, P. W. Kalivas, Cassandra D. Gipson, Douglas Roberts-Wolfe, Jasper A. Heinsbroek, Sade Spencer, Michael D. Scofield, Yonatan M. Kupchik
Publikováno v:
Pharmacological Reviews. 68:816-871
The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical and limbic structures to mediate goal-directed behaviors. Chronic exposure to several classes of drugs of abuse disrupts plasticity in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f02fe4d2906634d5125e9f4413fbe7
https://doi.org/10.1124/pr.116.012484
https://doi.org/10.1124/pr.116.012484