Zobrazeno 1 - 10
of 197
pro vyhledávání: '"M, Kooistra"'
Autor:
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R.J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113764- (2024)
Summary: Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response to vari
Externí odkaz:
https://doaj.org/article/bae07cfdb73044fea7306f15d1eb7d28
Autor:
Wendy Oost, Allard J. Huitema, Kim Kats, Ben N. G. Giepmans, Susanne M. Kooistra, Bart J. L. Eggen, Wia Baron
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which increases axo
Externí odkaz:
https://doaj.org/article/95bce4d9d47941768755f87d87b64b26
Autor:
Kitty Reemst, Laura Kracht, Janssen M. Kotah, Reza Rahimian, Astrid A. S. van Irsen, Gonzalo Congrains Sotomayor, Laura N. Verboon, Nieske Brouwer, Sophie Simard, Gustavo Turecki, Naguib Mechawar, Susanne M. Kooistra, Bart J. L. Eggen, Aniko Korosi
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, th
Externí odkaz:
https://doaj.org/article/db2a1285bcce4eab802b36ede32826ef
Autor:
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative s
Externí odkaz:
https://doaj.org/article/3973528986d64d68a5883cd398983c49
Autor:
Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans-Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point towards
Externí odkaz:
https://doaj.org/article/e6a6235939ee4b9089024f9f8ef305b6
Autor:
Malte Borggrewe, Susanne M. Kooistra, Evelyn M. Wesseling, Fenja L. Gierschek, Maaike L. Brummer, Elizabeth C. Nowak, Tiago Medeiros-Furquim, Tegan A. Otto, Sam W. Lee, Randolph J. Noelle, Bart J. L. Eggen, Jon D. Laman
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is a negative checkpoint regulator (NCR) that is involved in T-cell quiescence, inhibition of T-cell activation, and in myeloid cells regulates cytokine producti
Externí odkaz:
https://doaj.org/article/4bdc13e15de849f6a6de101e17552924
Autor:
Eric A. Nalefski, Nidhi Patel, Philip J.Y. Leung, Zeba Islam, Remy M. Kooistra, Ishira Parikh, Estelle Marion, Gavin J. Knott, Jennifer A. Doudna, Anne-Laure M. Le Ny, Damian Madan
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102996- (2021)
Summary: Bacterial CRISPR systems provide acquired immunity against invading nucleic acids by activating RNA-programmable RNases and DNases. Cas13a and Cas12a enzymes bound to CRISPR RNA (crRNA) recognize specific nucleic acid targets, initiating cle
Externí odkaz:
https://doaj.org/article/80d19e1840ea49a8a0286554c752aad5
Autor:
Margriet Piersma‐Wichers, Tessa Elling, Anne M. B. deVries‐Bots, Hilde A. M. Kooistra, Karina Meijer
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 6, Pp n/a-n/a (2021)
Abstract Background Direct oral anticoagulants (DOACs) are the preferred anticoagulants for thromboprophylaxis in atrial fibrillation. We aimed to identify determinants of quality of life related to DOAC treatment to optimize DOAC treatment convenien
Externí odkaz:
https://doaj.org/article/31ee1293092d4a36bfdb8f99f7c18f03
Autor:
Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L. Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M. Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P. Biber, Susanne M. Kooistra, Erik W. G. M. Boddeke, Bart J. L. Eggen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation in Alzheimer
Externí odkaz:
https://doaj.org/article/cf41d44a7139428b829cb962c615f345
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Microglia are important for central nervous system (CNS) homeostasis and first to respond to tissue damage and perturbations. Microglia are heterogeneous cells; in case of pathology, microglia adopt a range of phenotypes with altered functions. Howev
Externí odkaz:
https://doaj.org/article/448a28c48cc54b3f898346ab0db1f221