Zobrazeno 1 - 10
of 6 164
pro vyhledávání: '"M, Kessler"'
Autor:
Alberto Mendoza‐Valderrey, Jane Choe, Daria M. Kessler, Gianna Jimenez, Xinmin Li, Steven Kolker, Warren Allen, Jennifer A. Linehan, Przemyslaw W. Twardowski, Maria Libera Ascierto
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Background Neoadjuvant cisplatin‐based chemotherapy (NAC) followed by cystectomy is the standard of care for patients with muscle‐invasive bladder cancer (MIBC). Pathologic complete response (pCR) is associated with favorable outcomes, b
Externí odkaz:
https://doaj.org/article/02d7ef7048a2464ca5aae28cc305f034
Autor:
Darshana Poddar, Nikhil Sharma, Tomoaki Ogino, Xu Qi, Patricia M. Kessler, Hiran Mendries, Ranjan Dutta, Ganes C. Sen
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The interferon (IFN) system protects mammals from diseases caused by virus infections. IFN synthesis is induced by pattern recognition receptor signaling pathways activated by virus infection. IFN is secreted from the infected cells and acts
Externí odkaz:
https://doaj.org/article/f38230ffa2eb43bfbd81376250bad105
Autor:
Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward Jenkins, Frederik H. Lassen, Sam J. Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou, Fangyuan Cao, Xiaonan Zheng, Ricardo A. Fernandes, Tao Dong, Edward W. Tate, Elena Di Daniel, Benedikt M. Kessler
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114152- (2024)
Summary: Activation of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome complex is an essential innate immune signaling mechanism. To reveal how human NLRP3 inflammasome assembly and activation are controlled, in particular b
Externí odkaz:
https://doaj.org/article/a5167cfa972c4f8d8edd1f27601d7520
Autor:
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R. Healy, Kymberly Levine, Erik C. Ralph, Masaya Yamaguchi, Ziyue Karen Jiang, Edward Cabral, Yingrong Xu, Jeffrey Stock, Bing Yang, Anand Giddabasappa, Paula Loria, Agustin Casimiro-Garcia, Benedikt M. Kessler, Adán Pinto-Fernández, Véronique Frattini, Paul D. Wes, Feng Wang
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109593- (2024)
Summary: Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. Type I interferon signaling is negatively regulated by USP18. USP18 cleaves ISG15, an interferon-induced ubiquitin-l
Externí odkaz:
https://doaj.org/article/9891ba2dcc8a4ca097d1e8e73e654873
Autor:
N. E. Topalov, D. Mayr, C. Kuhn, A. Leutbecher, C. Scherer, F. B. T. Kraus, C. V. Tauber, S. Beyer, S. Meister, A. Hester, T. Kolben, A. Burges, S. Mahner, F. Trillsch, M. Kessler, U. Jeschke, B. Czogalla
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Actin beta-like 2 (ACTBL2) was recently identified as a new mediator of migration in ovarian cancer cells. Yet, its impact on tumor-infiltrating and thus migrating leukocytes (TILs) remains to date unknown. This study characterizes the subse
Externí odkaz:
https://doaj.org/article/c9e20a8e628744869c10fe6abac1a5ff
Autor:
Miriam Krumbein, Froma Oberman, Yuval Cinnamon, Mordechai Golomb, Dalit May, Gilad Vainer, Vitali Belzer, Karen Meir, Irina Fridman, Johannes Haybaeck, Gerhard Poelzl, Izhak Kehat, Ronen Beeri, Sonja M. Kessler, Joel K. Yisraeli
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The IGF2BP family of RNA binding proteins consists of three paralogs that regulate intracellular RNA localization, RNA stability, and translational control. Although IGF2BP1 and 3 are oncofetal proteins, IGF2BP2 expression is maintained in m
Externí odkaz:
https://doaj.org/article/d88543a9bb2e446cb1e179d0e5dbafe2
Autor:
Simon Davis, Connor Scott, Janina Oetjen, Philip D. Charles, Benedikt M. Kessler, Olaf Ansorge, Roman Fischer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for u
Externí odkaz:
https://doaj.org/article/a9c62d9e72e54c4baedf487a7e9f1c8a
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/1765f5361e9a43bfbf6c9f03b086f2c0
Autor:
Vera Neumeier, Fabian P. Stangl, Joëlle Borer, Collene E. Anderson, Veronika Birkhäuser, Oksana Chemych, Oliver Gross, Miriam Koschorke, Jonas Marschall, Shawna McCallin, Ulrich Mehnert, Helen Sadri, Lara Stächele, Thomas M. Kessler, Lorenz Leitner
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Patients with neurogenic lower urinary tract dysfunction (NLUTD) often rely on some type of catheterization for bladder emptying. Intermittent catheterization (IC) is considered the gold standard and is preferred over continuous c
Externí odkaz:
https://doaj.org/article/bcd1c27585334300ae29b6953e5800ca
Autor:
Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I. Matter, Lorenz Leitner, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacterial
Externí odkaz:
https://doaj.org/article/15efe631889b4075b2703227b046234f