Zobrazeno 1 - 10
of 461
pro vyhledávání: '"M, Keogh"'
Autor:
Garrett W. Hopper, Jamie R. Bucholz, Traci P. DuBose, Kaelyn J. Fogelman, Sean M. Keogh, Megan E. Kubala, Matthew B. Lodato, David H. Nichols, Irene Sánchez González, John M. Pfeiffer, James A. Stoeckel, Jeffrey D. Lozier, Carla L. Atkinson
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-15 (2023)
Abstract The United States of America has a diverse collection of freshwater mussels comprising 301 species distributed among 59 genera and two families (Margaritiferidae and Unionidae), each having a unique suite of traits. Mussels are among the mos
Externí odkaz:
https://doaj.org/article/5fe5e9d8a59d40e5a89ea51a1df003cb
Autor:
Fleur Talbot, Claire H. Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M. Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S. H. Yeo, Philippe Froguel, David A. Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M. Luckman, I. Sadaf Farooqi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice,
Externí odkaz:
https://doaj.org/article/ae488579c70a4e4895c6b257ff54f30c
Autor:
Anthony L. Gaeta, Karolina Willicott, Corey W. Willicott, Luke E. McKay, Candice M. Keogh, Tyler J. Altman, Logan C. Kimble, Abigail L. Yarbrough, Kim A. Caldwell, Guy A. Caldwell
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106859- (2023)
Summary: Failure of inherently protective cellular processes and misfolded protein-associated stress contribute to the progressive loss of dopamine (DA) neurons characteristic of Parkinson’s disease (PD). A disease-modifying role for the microbiome
Externí odkaz:
https://doaj.org/article/110ccf8d94304ef59fa69e95a0718c71
Autor:
Anthony L Gaeta, J Brucker Nourse, Karolina Willicott, Luke E McKay, Candice M Keogh, Kylie Peter, Shannon N Russell, Shusei Hamamichi, Laura A Berkowitz, Kim A Caldwell, Guy A Caldwell
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010115 (2022)
The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to both internal and external factors have i
Externí odkaz:
https://doaj.org/article/53708f6cb73f44008e3c22599f1098fc
Autor:
Aliki Perdikari, Tessa Cacciottolo, Elana Henning, Edson Mendes de Oliveira, Julia M. Keogh, I. Sadaf Farooqi
Publikováno v:
Open Biology, Vol 12, Iss 3 (2022)
Obesity, defined as an excess of adipose tissue that adversely affects health, is a major cause of morbidity and mortality. However, to date, understanding the structure and function of human adipose tissue has been limited by the inability to visual
Externí odkaz:
https://doaj.org/article/bbcbc4efd32342f28040931f56db7f20
Autor:
Neha Agrawal, Katherine Lawler, Catherine M. Davidson, Julia M. Keogh, Robert Legg, INTERVAL, Inês Barroso, I. Sadaf Farooqi, Andrea H. Brand
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establis
Externí odkaz:
https://doaj.org/article/79111040580e450d8f11ece9a93f657d
Autor:
Rebekah M. Ahmed, Ramon Landin‐Romero, Cheng T. Liang, Julia M. Keogh, Elana Henning, Cherie Strikwerda‐Brown, Emma M. Devenney, John R. Hodges, Matthew C. Kiernan, I. Sadaf Farooqi, Olivier Piguet
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1707-1717 (2019)
Abstract Background Frontotemporal dementia (FTD) is associated with complex changes in eating behavior and metabolism, which potentially affect disease pathogenesis and survival. It is currently not known if body composition changes and changes in f
Externí odkaz:
https://doaj.org/article/6eaf4999d8dc45ce88d741a731da0db9
Autor:
Yongjie Yang, Agatha A. van der Klaauw, Liangru Zhu, Tessa M. Cacciottolo, Yanlin He, Lukas K. J. Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M. Keogh, Elana Henning, Matthew C. Banton, Audrey E. Hendricks, Elena G. Bochukova, Vanisha Mistry, Katherine L. Lawler, Lan Liao, Jianming Xu, Stephen O’Rahilly, Qingchun Tong, UK10K Consortium, Inês Barroso, Bert W. O’Malley, I. Sadaf Farooqi, Yong Xu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obe
Externí odkaz:
https://doaj.org/article/1d82850af2594a8381d4f4b41b3524ec
Autor:
Nicole K. Bart, Sara L. Hungerford, Mayooran Namasivayam, Emily Granger, Mark Conellan, Eugene Kotlyar, Kavitha Muthiah, Andrew Jabbour, Christopher Hayward, Paul C. Jansz, Anne M. Keogh, Peter S. Macdonald
Publikováno v:
Transplantation. 107:1390-1397
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d27c6889783cbb7e3681302823d617d
https://doi.org/10.1097/tp.0000000000004511
https://doi.org/10.1097/tp.0000000000004511
Autor:
Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola B.F. Monteiro, Suli-Anne Laurin, Julia M. Keogh, Elana Henning, Rebecca Bounds, Carole A. Daly, Shane Houston, Vikram Ayinampudi, Natalia Wasiluk, David Clarke, Bianca Plouffe, Michel Bouvier, M. Madan Babu, I. Sadaf Farooqi, Jacek Mokrosiński
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108862- (2021)
Summary: The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function. Most obesity-associated
Externí odkaz:
https://doaj.org/article/47adf08d015c4c769ac1331dc6211c1b