Výsledky vyhledávání

Evaluation of antitumor activity of gefitinib in pediatric glioblastoma and neuroblastoma cells

Autor: K, Hatziagapiou, M, Braoudaki, M, Karpusas, F, Tzortzatou-Stathopoulou

Publikováno v: Clinical laboratory. 57(9-10)

This work was undertaken to investigate the efficacy of gefitinib, an EGFR tyrosine kinase inhibitor, in tumor cell lines of the CNS by studying cell proliferation and phosphorylation of the tyrosine kinase domain ofThe study included neuroblastoma (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::161613382cb7835e1f403f11e6e575ac
https://pubmed.ncbi.nlm.nih.gov/22029196

Zobrazit plný text záznamu

Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia

Autor: Braoudaki, M. Karpusas, M. Katsibardi, K. Papathanassiou, C. Karamolegou, K. Tzortzatou-Stathopoulou, F.

FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL). These most frequently manifest as internal tandem duplications (ITD) and activation loop (AL) mutations. This study investigated the incidence of FLT3 mutations in 86 ped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::73e85d52fe4139c7cfb78934e08264db
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3090152

Zobrazit plný text záznamu

An aggressive form of polyarticular arthritis in a man with CD154 mutation (X-linked hyper-IgM syndrome)

Autor: E A, Webster, A Y, Khakoo, W J, Mackus, M, Karpusas, D W, Thomas, A, Davidson, C L, Christian, S, Lederman

Publikováno v: Arthritis and rheumatism. 42(6)

Hyper-IgM syndrome (HIM) is a rare immunodeficiency disorder that has been associated with the development of symptoms and clinical features characteristic of rheumatoid arthritis (RA). We describe a patient with HIM and severe erosive arthritis with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5637055023c7cd7bfb6bd50e15b85e2c
https://pubmed.ncbi.nlm.nih.gov/10366125

Zobrazit plný text záznamu

Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta)

Autor: L, Runkel, W, Meier, R B, Pepinsky, M, Karpusas, A, Whitty, K, Kimball, M, Brickelmaier, C, Muldowney, W, Jones, S E, Goelz

Publikováno v: Pharmaceutical research. 15(4)

Two recombinant IFN-beta products have been approved for the treatment of multiple sclerosis, a glycosylated form with the predicted natural amino acid sequence (IFN-beta-1a) and a non-glycosylated form that has a Met-1 deletion and a Cys-17 to Ser m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce667b145a274b6d6bc016a96cab059d
https://pubmed.ncbi.nlm.nih.gov/9587963

Zobrazit plný text záznamu

Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A

Autor: M, Karpusas, B, Branchaud, S J, Remington

Publikováno v: Biochemistry. 29(9)

The crystal structure of the ternary complex citrate synthase-oxaloacetate-carboxymethyl coenzyme A has been solved to a resolution of 1.9 A and refined to a conventional crystallographic R factor of 0.185. The structure resembles a proposed transiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e4917b0fa8caab278d0211ecf7ade60
https://pubmed.ncbi.nlm.nih.gov/2337600

Zobrazit plný text záznamu

Approaches toward the Design of Proteins of Enhanced Thermostability

Autor: T. Alber, Dale E. Tronrud, Brian W. Matthews, H. Nicholson, Philip Pjura, L. H. Weaver, R. H. Jacobson, S. Dao-pin, Jeffrey A. Bell, R. Faber, J. A. Wozniak, Masazumi Matsumura, X.J. Zhang, M. Karpusas, K. Wilson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1c644d1c23ea7162e88fe8f67b4bee4
https://doi.org/10.1016/b978-0-12-438745-4.50023-9

Zobrazit plný text záznamu

Crystallographic and Genetic Approaches Toward the Design of Proteins of Enhanced Thermostability

Autor: Raymond H. Jacobson, K. Wilson, T. Alber, X.J. Zhang, R. Faber, Jeffrey A. Bell, J. A. Wozniak, M. Karpusas, Dale E. Tronrud, Brian W. Matthews, L. H. Weaver, Philip Pjura, H. Nicholson, Masazumi Matsumura, S. Dao-pin

Publikováno v: Crystallographic and Modeling Methods in Molecular Design ISBN: 9781461279877

The advent of directed mutagenesis has made it possible to alter protein structures at will. For the first time it is possible to design and to introduce modifications into a protein that are intended to change its behavior in predictable ways.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::180817d7077620c8c273a927245b87a5
https://doi.org/10.1007/978-1-4612-3374-9_6

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání