Zobrazeno 1 - 10
of 341
pro vyhledávání: '"M, Jokinen"'
Autor:
Lisa J. Neilson, Douglas Cartwright, Maija Risteli, Elina M. Jokinen, Lynn McGarry, Toni Sandvik, Konstantina Nikolatou, Kelly Hodge, Samuel Atkinson, Maria Vias, Emily J. Kay, James D. Brenton, Leo M. Carlin, David M. Bryant, Tuula Salo, Sara Zanivan
Publikováno v:
Matrix Biology Plus, Vol 19, Iss , Pp 100136- (2023)
High-grade serous (HGS) ovarian cancer is the most lethal gynaecological disease in the world and metastases is a major cause. The omentum is the preferential metastatic site in HGS ovarian cancer patients and in vitro models that recapitulate the or
Externí odkaz:
https://doaj.org/article/d4dce9ee5303495aaec66cd09d019f16
Autor:
Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio, Olli T. Pentikäinen
Publikováno v:
ACS Omega, Vol 6, Iss 17, Pp 11286-11296 (2021)
Externí odkaz:
https://doaj.org/article/d98e760f25234a2f80683f7c9d6217d5
Autor:
Elmeri M. Jokinen, Miika Niemeläinen, Sami T. Kurkinen, Jukka V. Lehtonen, Sakari Lätti, Pekka A. Postila, Olli T. Pentikäinen, Sanna P. Niinivehmas
Publikováno v:
Molecules, Vol 28, Iss 8, p 3420 (2023)
Molecular docking is a key method used in virtual screening (VS) campaigns to identify small-molecule ligands for drug discovery targets. While docking provides a tangible way to understand and predict the protein-ligand complex formation, the dockin
Externí odkaz:
https://doaj.org/article/def2c2d7cd9d43a18836191ef31d6b7a
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The COVID-19 pandemic, caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a severe global health crisis now. SARS-CoV-2 utilizes its Spike protein receptor-binding domain (S-protein) to invade human cell through binding
Externí odkaz:
https://doaj.org/article/12d67effe17b41ff83ffc64f025b4a16
Akademický článek
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Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 18:1281-1289
The novel SARS-CoV-2 uses ACE2 (Angiotensin-Converting Enzyme 2) receptor as an entry point. Insights on S protein receptor-binding domain (RBD) interaction with ACE2 receptor and drug repurposing has accelerated drug discovery for the novel SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a307746f221a97abb2964cf2a56d9ef5
https://doi.org/10.1109/tcbb.2021.3076259
https://doi.org/10.1109/tcbb.2021.3076259
Autor:
Mira Ahinko, Risto O. Juvonen, Elmeri M. Jokinen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
ACS Omega, Vol 6, Iss 17, Pp 11286-11296 (2021)
ACS Omega
ACS Omega
Of the three enzymes in the human cytochrome P450 family 1, CYP1A2 is an important enzyme mediating metabolism of xenobiotics including drugs in the liver, while CYP1A1 and CYP1B1 are expressed in extrahepatic tissues. Currently used CYP substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137651e7405633df3c5a11400380b9b
https://doi.org/10.1021/acsomega.1c00123
https://doi.org/10.1021/acsomega.1c00123
Autor:
H Soltani, H Watson, F Fair, M van den Muijsenbergh, M Papadakaki, M Jokinen, E Sioti, L Raben, C Burke, V Vivilaki
Publikováno v:
European Journal of Public Health. 31
Perinatal mental health disorders are among the most common morbidities of the perinatal period with considerable adverse effects on mothers and their offspring. Members of ethnic minority groups, particularly those from migrant backgrounds, are at h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e438f59ccabc15c63eb04dc147fb973
https://doi.org/10.1093/eurpub/ckab164.467
https://doi.org/10.1093/eurpub/ckab164.467
Publikováno v:
Chemical Biology & Drug Design. 93:522-538
The estimation of the correct binding mode and affinity of a ligand into a target protein using computational methods is challenging. However, docking can introduce poses from which the correct binding mode could be identified using other methods. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d42213c26a3c853175378b23939a40
https://doi.org/10.1111/cbdd.13446
https://doi.org/10.1111/cbdd.13446
Autor:
Hannu Raunio, Juhani Huuskonen, Elmeri M. Jokinen, Risto O. Juvonen, Olli Kärkkäinen, Olli T. Pentikäinen
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(11)
CYP2A13 enzyme is expressed in human extrahepatic tissues, while CYP2A6 is a hepatic enzyme. Reactions catalysed by CYP2A13 activate tobacco-specific nitrosamines and some other toxic xenobiotics in lungs.To compare oxidation characteristics and subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc946c85c4c8b8f03a85bef47c020d
https://pubmed.ncbi.nlm.nih.gov/33703988
https://pubmed.ncbi.nlm.nih.gov/33703988