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Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin:A Metgen Meta-Analysis

Autor: T, Dujic, K, Zhou, S W, Yee, N, van Leeuwen, C E, de Keyser, M, Javorský, S, Goswami, L, Zaharenko, M M, Hougaard Christensen, M, Out, R, Tavendale, M, Kubo, M M, Hedderson, A A, van der Heijden, L, Klimčáková, V, Pirags, A, Kooy, K, Brøsen, J, Klovins, S, Semiz, I, Tkáč, B H, Stricker, Cna, Palmer, L M, 't Hart, K M, Giacomini, E R, Pearson

Publikováno v: Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Hougaard Christensen, M M, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A Metgen Meta-Analysis ', Clinical Pharmacology and Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical Pharmacology and Therapeutics, 101(6), 763-772
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Christensen, M M H, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A MetGen Meta-Analysis ', Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical pharmacology and therapeutics, vol 101, iss 6
Clinical Pharmacology & Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics

Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b762e525da754cb923dd8b91cd06ac1f
https://research.vumc.nl/en/publications/508fedaf-498a-4e2d-91a9-f7fedd97684b

The effect of alfacalcidiol and metformin on phenotype manifestations in women with polycystic ovary syndrome - a preliminary study

Autor: Ingrid Dravecká, Ivica Lazúrová, Jana Figurová, J Petrikova, M Vaľková, M Javorský

Publikováno v: Physiological research. 65(5)

Aim of this study was to evaluate the effect of vitamin D supplementation in obese, insulin resistant and vitamin D deficient PCOS women on biochemical and clinical hyperandrogenism and menstrual irregularity in comparison to effect of metformin or c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b1382dd94b035a22f5897752e9cc2e
https://pubmed.ncbi.nlm.nih.gov/27429113

[Relationship of the CDKAL1 and KCNQ1 gene polymorphisms to the age at diagnosis of type 2 diabetes in the Slovakian population]

Autor: M, Dobríková, M, Javorský, V, Habálová, L, Klimcáková, M, Kozárová, J, Zidzik, J, Halusková, J, Salagovic, I, Tkác

Publikováno v: Vnitrni lekarstvi. 57(2)

The association of CDKAL1 and KCNQ1 genes with type 2 diabetes mellitus (DM2T) was confirmed by several genome-wide association studies in both Caucasian and Asian populations. For both genes, it is supposed that the risk of DM2T development is relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::047a14d11500cef055691f35aa0bba42
https://pubmed.ncbi.nlm.nih.gov/21416849

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