Zobrazeno 1 - 10
of 171
pro vyhledávání: '"M, Haskins"'
Publikováno v:
IUCrJ, Vol 10, Iss 3, Pp 329-340 (2023)
Hesperetin (HES) is a weakly acidic flavonoid of topical interest owing to its antiviral properties. Despite the presence of HES in many dietary supplements, its bioavailability is hindered by poor aqueous solubility (1.35 µg ml−1) and rapid first
Externí odkaz:
https://doaj.org/article/c4199a6be2c24571bdd0ba5e30cb0511
Publikováno v:
Crystal Growth & Design. 22:3333-3342
Approximately 80% of active pharmaceutical ingredients (APIs) studied as lead candidates in drug development exhibit low aqueous solubility, which typically results in such APIs being poorly absorbed and exhibiting low bioavailability. Salts of ioniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5873bf5a531c50c2d782853990e3570
https://doi.org/10.1021/acs.cgd.2c00150
https://doi.org/10.1021/acs.cgd.2c00150
Autor:
Shasha Jin, Molly M. Haskins, Yassin H. Andaloussi, Ruiling Ouyang, Junbo Gong, Michael J. Zaworotko
We report the existence of conformational polymorphism in an ionic cocrystal (ICC) of the nutraceutical compound hesperetin (HES) in which its tetraethylammonium (TEA+) salt serves as a coformer. Three polymorphs, HESTEA-α, HESTEA-β and HESTEA-γ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2e47b10f288a77a4d5af028767d990
Autor:
Chenghua Deng, Bai-Qiao Song, Matteo Lusi, Andrey A. Bezrukov, Molly M. Haskins, Mei-Yan Gao, Yun-Lei Peng, Jian-Gong Ma, Peng Cheng, Soumya Mukherjee, Michael J. Zaworotko
Chiral metal−organic materials (CMOMs), can offer molecular binding sites that mimic the enantioselectivity exhibited by biomolecules and are amenable to systematic fine-tuning of structure and properties. Herein, we report that the reaction of Ni(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bd38ca6109c7edf943d7c17b36d979
Approximately 80% of active pharmaceutical ingredients (APIs) studied as lead candidates in drug development exhibit low aqueous solubility, which typically results in such APIs being poorly absorbed and exhibiting low bioavailability. Salts of ioniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b71083213ec5374330a9df85ec85ff
Autor:
M. Haskins, Molly, Kavanagh, Oisín N., Sanii, Rana, Khorasani, Sanaz, Chen, Jia-Mei, Zhang, Zhi-Yuan, Dai, Xia-Lin, Ren, Bo-Ying, Lu, Tong-Bu, ZAWOROTKO, MICHAEL
Quercetin (QUE) is a widely studied nutraceutical with a number of potential therapeutic properties. Although QUE is abundant in the plant kingdom, its poor solubility (≤20 μg/mL) and poor oral bioavailability have impeded its potential utility an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bb47f00a9251955604117c8a83199d
Autor:
Michael J. Zaworotko, Molly M. Haskins
Publikováno v:
Crystal Growth & Design
Cocrystals of biologically active molecular compounds have potential utility in drug products thanks to their effect upon physicochemical properties such as aqueous solubility. The fact that control of cocrystallization can be more challenging than c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07822025c83854d4b9c9eeb746d2399
https://doi.org/10.1021/acs.cgd.1c00418
https://doi.org/10.1021/acs.cgd.1c00418
Autor:
Gary K. Owens, Giuseppe Mocci, Santosh Karnewar, Stefan Bekiranov, Vamsidhar M Venkata, Katherine Owsiany, Anh T. Nguyen, Corey M. Williams, Richard A. Baylis, Sohel Shamsuzzaman, Katyayani Sukhavasi, Aloke V. Finn, Ryan M. Haskins, Christopher A. Henderson, Michal Mokry, Eli R. Zunder, Coleen A. McNamara, Johan L.M. Björkegren, Gabriel F. Alencar, Gerard Pasterkamp
Publikováno v:
Circulation
Supplemental Digital Content is available in the text.
Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we have a limited unde
Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we have a limited unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8d15a28bec9a6a1c3faf9d35bb208c
https://doi.org/10.1161/circulationaha.120.046672
https://doi.org/10.1161/circulationaha.120.046672
Publikováno v:
Annals of International Occupational Therapy. 2:115-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a20d3b815797df7e647abdde00d758
https://doi.org/10.3928/24761222-20190314-02
https://doi.org/10.3928/24761222-20190314-02
Autor:
Laura S. Shankman, Gary K. Owens, Gamze B. Bulut, Anh T. Nguyen, Lillian K. Waller, Santosh Karnewar, Rebecca A. Deaton, Ryan M. Haskins, Susanna R. Keller, Gabriel F. Alencar, Katherine Owsiany, Olga A. Cherepanova
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
Objective:Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise toKlf4-dependent macrophage-like cells that augment adipose tissue (AT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e6796632baddd5d050ddfd42f7491d
https://doi.org/10.1161/atvbaha.120.314703
https://doi.org/10.1161/atvbaha.120.314703