Zobrazeno 1 - 10
of 941
pro vyhledávání: '"M, Hallström"'
Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues
Autor:
Basak Eraslan, Dongxue Wang, Mirjana Gusic, Holger Prokisch, Björn M Hallström, Mathias Uhlén, Anna Asplund, Frederik Pontén, Thomas Wieland, Thomas Hopf, Hannes Hahne, Bernhard Kuster, Julien Gagneur
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 2, Pp 1-25 (2019)
Abstract Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a quantification of their effects are still lacking. Here, we quantified PTR ratios fo
Externí odkaz:
https://doaj.org/article/e19bbe0271ae4aadb03af672401fd357
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The contribution of metabolic pathways to protein secretion is largely unknown. Here, the authors find conserved metabolic patterns in yeast by examining genome-wide transcriptional responses in high protein secretion mutants and reveal critical fact
Externí odkaz:
https://doaj.org/article/f678b36925754173ae342618040dbd75
Autor:
Adil Mardinoglu, Elias Bjornson, Cheng Zhang, Martina Klevstig, Sanni Söderlund, Marcus Ståhlman, Martin Adiels, Antti Hakkarainen, Nina Lundbom, Murat Kilicarslan, Björn M Hallström, Jesper Lundbom, Bruno Vergès, Peter Hugh R Barrett, Gerald F Watts, Mireille J Serlie, Jens Nielsen, Mathias Uhlén, Ulf Smith, Hanns‐Ulrich Marschall, Marja‐Riitta Taskinen, Jan Boren
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 3, Pp 1-17 (2017)
Abstract To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individ
Externí odkaz:
https://doaj.org/article/e43610ba34b24032ab9bcfbc35617cd8
Autor:
Fredrik Edfors, Frida Danielsson, Björn M Hallström, Lukas Käll, Emma Lundberg, Fredrik Pontén, Björn Forsström, Mathias Uhlén
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 10, Pp 1-10 (2016)
Abstract An important issue for molecular biology is to establish whether transcript levels of a given gene can be used as proxies for the corresponding protein levels. Here, we have developed a targeted proteomics approach for a set of human non‐s
Externí odkaz:
https://doaj.org/article/5cd4c0015d724763a7c0a31f4bd30b5c
Autor:
Mathias Uhlén, Björn M Hallström, Cecilia Lindskog, Adil Mardinoglu, Fredrik Pontén, Jens Nielsen
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp 1-12 (2016)
Abstract Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease. Recently, several large‐scale transcriptomics studies have analyzed the expression of pr
Externí odkaz:
https://doaj.org/article/c6279c823e8b41ceb63eb9ec06c6dc07
Autor:
Xander M. van Wijk, Simon Döhrmann, Björn M. Hallström, Shangzhong Li, Bjørn G. Voldborg, Brandon X. Meng, Karen K. McKee, Toin H. van Kuppevelt, Peter D. Yurchenco, Bernhard O. Palsson, Nathan E. Lewis, Victor Nizet, Jeffrey D. Esko
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT To understand the role of glycosaminoglycans in bacterial cellular invasion, xylosyltransferase-deficient mutants of Chinese hamster ovary (CHO) cells were created using clustered regularly interspaced short palindromic repeat (CRISPR) and C
Externí odkaz:
https://doaj.org/article/b977856af4b74bdaa8a1ed1c0e80562c
Autor:
Michael Palmgren, Karin Engström, Björn M Hallström, Karin Wahlberg, Dan Ariel Søndergaard, Torbjörn Säll, Marie Vahter, Karin Broberg
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175422 (2017)
Organisms have evolved the ability to tolerate toxic substances in their environments, often by producing metabolic enzymes that efficiently detoxify the toxicant. Inorganic arsenic is one of the most toxic and carcinogenic substances in the environm
Externí odkaz:
https://doaj.org/article/df4782cbfcc54830a786fe01f0dfbcf3
Autor:
Ulfur Arnason, Björn M. Hallström
Publikováno v:
Hereditas, Vol 157, Iss 1, Pp 1-13 (2020)
Hereditas
Hereditas
BackgroundThe molecular out of Africa hypothesis, OOAH, has been considered as an established fact amid population geneticists for some 25–30 years despite the early concern with it among phylogeneticists with experience beyond that ofHomo. The pal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2093677eaf527939bc3c325e8f1364
https://doaj.org/article/bb7ee6e4a03042d2b8e87ea7802fc1fe
https://doaj.org/article/bb7ee6e4a03042d2b8e87ea7802fc1fe
Autor:
Evelina Sjöstedt, Linn Fagerberg, Björn M Hallström, Anna Häggmark, Nicholas Mitsios, Peter Nilsson, Fredrik Pontén, Tomas Hökfelt, Mathias Uhlén, Jan Mulder
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130028 (2015)
The mammalian brain is a complex organ composed of many specialized cells, harboring sets of both common, widely distributed, as well as specialized and discretely localized proteins. Here we focus on the human brain, utilizing transcriptomics and pu
Externí odkaz:
https://doaj.org/article/616cf32f1faf4e85b52cdc1333da35d2
Autor:
Gillian O'Hurley, Christer Busch, Linn Fagerberg, Björn M Hallström, Charlotte Stadler, Anna Tolf, Emma Lundberg, Jochen M Schwenk, Karin Jirström, Anders Bjartell, William M Gallagher, Mathias Uhlén, Fredrik Pontén
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133449 (2015)
To better understand prostate function and disease, it is important to define and explore the molecular constituents that signify the prostate gland. The aim of this study was to define the prostate specific transcriptome and proteome, in comparison
Externí odkaz:
https://doaj.org/article/59ff769d9ca449d28ad14f11428ec800