Zobrazeno 1 - 10
of 168
pro vyhledávání: '"M, Hagopian"'
Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Radioactive or stable isotopic labeling of metabolites is a strategy that is routinely used to map the cellular fate of a selected labeled metabolite after it is added to cell culture or to the circulation of an animal. However, a
Externí odkaz:
https://doaj.org/article/d3d6c5c2b4f44ad0a75f8c53c0e7c2e2
Autor:
Rolf A. Brekken, Ke Ding, Xiaomei Ren, Diego H. Castrillon, Jason B. Fleming, Huamin Wang, Tae Hyun Hwang, Stefan Hinz, Zhen Wang, Moriah M. Hagopian, Wenting Du, Huocong Huang, Kristina Y. Aguilera
Supplementary Figure 1: 7rh reduces collagen-mediated signaling in a concentration-dependent manner in vivo; Supplementary Figure 2: 7rh inhibits Ddr1 activation in Pan02 tumors; Supplementary Figure 3: Inhibition of Ddr1 with 7rh does not induce obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e507d5d902b1df65cddbef5e96636f
https://doi.org/10.1158/1535-7163.22508715.v1
https://doi.org/10.1158/1535-7163.22508715.v1
Autor:
Rolf A. Brekken, Kyla D. Carroll, Lee B. Rivera, Mary Topalovski, Moriah M. Hagopian, Desiree Nugent, Xiaohong Xu, Risheng Ye, Miao Wang, Bercin Kutluk Cenik, Katherine T. Ostapoff
Supplemental Figures S1-S12. 2G8 does not bind to human TGFβR2 (S1); 2G8 treated stromal cells do not induce tumor cell proliferation (S2); 2G8 inhibits smad2 dependent signaling in a dose dependent fashion (S3); Tgfβr2 inhibition induces apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d11dacba7f4588fb5a977227edef49
https://doi.org/10.1158/0008-5472.22400564.v1
https://doi.org/10.1158/0008-5472.22400564.v1
Autor:
Rolf A. Brekken, Kyla D. Carroll, Lee B. Rivera, Mary Topalovski, Moriah M. Hagopian, Desiree Nugent, Xiaohong Xu, Risheng Ye, Miao Wang, Bercin Kutluk Cenik, Katherine T. Ostapoff
Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca04d8a78a8d36efc3da17a710e8856d
https://doi.org/10.1158/0008-5472.c.6505616
https://doi.org/10.1158/0008-5472.c.6505616
Autor:
Anne Hope Jahren, William M. Hagopian
Publikováno v:
Naturen. 145:248-252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2b769ed8f6bef0d9676b036580c194
https://doi.org/10.18261/issn.1504-3118-2021-05-07
https://doi.org/10.18261/issn.1504-3118-2021-05-07
Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-10 (2021)
BMC Biology
BMC Biology
Background Radioactive or stable isotopic labeling of metabolites is a strategy that is routinely used to map the cellular fate of a selected labeled metabolite after it is added to cell culture or to the circulation of an animal. However, a labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fc96be0652b77c8d7f0433b8f7e84a
https://doaj.org/article/d3d6c5c2b4f44ad0a75f8c53c0e7c2e2
https://doaj.org/article/d3d6c5c2b4f44ad0a75f8c53c0e7c2e2
Autor:
Petter Holland, Todd Andrew Schoborg, Ifat Abramovich, Szabolcs Takáts, Caroline Dillard, Ashish Jain, Fergal O'Farrell, Sebastian Wolfgang Schultz, William M. Hagopian, Eduardo Martin Quintana, Rachel Ng, Nadja Sandra Katheder, Mohammed Mahidur Rahman, José Gerardo Teles Reis, Andreas Brech, Heinrich Jasper, Nasser M. Rusan, Anne Hope Jahren, Eyal Gottlieb, Tor Erik Rusten
Publikováno v:
Molecular Cancer Research. 21:IA14-IA14
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec93a98b43e70c9a8169dd836a658ba1
https://doi.org/10.1158/1557-3125.ras23-ia14
https://doi.org/10.1158/1557-3125.ras23-ia14
Publikováno v:
Aesthetic Surgery Journal. 41:NP162-NP176
Background What constitutes adequate information for decision-making and informed consent is a practical question appropriately answered with deference to expertise. Objectives The aims of this study were: (1) to establish consensus on a procedure-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e43ffa670fa02edd00419ffa77080a
https://doi.org/10.1093/asj/sjaa341
https://doi.org/10.1093/asj/sjaa341
Akademický článek
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Autor:
Todd A. Schoborg, Eyal Gottlieb, Rachel K. Ng, Nadja Sandra Katheder, Nasser M. Rusan, Mohammed Mahidur Rahman, William M. Hagopian, Ashish Jain, José Gerardo Teles Reis, Szabolcs Takats, Tor Erik Rusten, Petter Holland, Ifat Abramovich, Rojyar Khezri, Caroline Dillard, Anne Hope Jahren, Eduardo Martin Quintana, Andreas Brech, Sebastian W. Schultz, Heinrich Jasper, Fergal O'Farrell
Publikováno v:
The EMBO Journal
During tumor growth—when nutrient and anabolic demands are high—autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras‐driven tumors additionally invoke non‐autonomous autophagy in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778751edfcf949ad9d63e0e1c5e6c52c
https://doi.org/10.15252/embj.2020107336
https://doi.org/10.15252/embj.2020107336