Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention

Autor: Clément M. Haeck, Peter Boyd, Nastasia Dimant, Aurélie Barrail-Tran, Hélène Gouget, Roger Le Grand, Delphine Desjardins, R. Karl Malcolm

Publikováno v: Haeck, C M, Boyd, P, Dimant, N, Barrail-Tran, A, Gouget, H, Le Grand, R, Desjardins, D & Malcolm, R K 2023, ' Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention ', Journal of Drug Delivery Science and Technology, vol. 85, 104590 . https://doi.org/10.1016/j.jddst.2023.104590

Depot injections comprising aqueous drug suspensions are widely marketed for long-acting administration of contraceptive progestins and antipsychotics. In recent years, there has been considerable interest in developing similar long-acting injectable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d7fe4b20d90db8626538b53308ade3
https://doi.org/10.1016/j.jddst.2023.104590

Polymorphism characterization of segesterone acetate: A comprehensive study using XRPD, FT-IR and Raman spectroscopy

Autor: Paulo César Morais, Bruce Variano, Fermin F.H. Aragon, Clement M. Haeck

Publikováno v: International Journal of Pharmaceutics. 596:120234

Segesterone acetate (SA) is a promising and recently approved drug substance used as a contraceptive. SA has two major polymorphic forms, Form I and II. We have shown through indirect analysis that Form I is the more thermodynamically stable polymorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a8e4edceee5c3fdec57aba390ad9ad
https://doi.org/10.1016/j.ijpharm.2021.120234

Une série de microangiopathies thrombotiques néoplasiques : modalités et importance pronostique d’un diagnostic précoce

Autor: M. Haeck, Thomas Quemeneur, A. Decaestecker, C. Cartery, M. Ulrich

Publikováno v: Néphrologie & Thérapeutique. 15:355

Introduction La microangiopathie thrombotique (MAT) est une pathologie rare au pronostic severe. Les progres therapeutiques, reposant sur les echanges plasmatiques et l’eculizumab, ont largement ameliore le pronostic. Ce traitement est peu efficace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7689c665db91b8e74226d2aca8baeab
https://doi.org/10.1016/j.nephro.2019.07.225

Comparison of methohexital and etomidate as anesthetic agents for electroconvulsive therapy in affective and psychotic disorders

Autor: Thomas Nickl-Jockschat, Benjamin Gillmann, Hildegard Janouschek, Michael Grözinger, M. Haeck

Publikováno v: Journal of Psychiatric Research. 47:686-693

Background ECT is a well-established treatment for severe depression. The available data on psychosis are limited, but reliable. Its therapeutic potential relies on the induction of a generalized seizure. Besides other narcotics, methohexital and eto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699adb2673b673e082960c87293cccb9
https://doi.org/10.1016/j.jpsychires.2012.12.019

Topical corticosteroids in atopic dermatitis and the risk of glaucoma and cataracts

Autor: I M Haeck, Marjolein S. de Bruin-Weller, C. A. F. M. Bruijnzeel-Koomen, Ton J. Rouwen, Linda Timmer-de Mik

Publikováno v: Journal of the American Academy of Dermatology. 64:275-281

Introduction There is concern about the development of glaucoma and cataracts associated with topical corticosteroid use in patients with atopic dermatitis (AD). Objective We evaluated glaucoma and cataract development in patients with AD to determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c24f03b7321ae60777362601adf1e9
https://doi.org/10.1016/j.jaad.2010.01.035