Zobrazeno 1 - 10
of 569
pro vyhledávání: '"M, Grochowska"'
Autor:
Katarzyna M. Grochowska, Marit Sperveslage, Rajeev Raman, Antonio V. Failla, Dawid Głów, Christian Schulze, Laura Laprell, Boris Fehse, Michael R. Kreutz
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112998- (2023)
Summary: The complex morphology of neurons poses a challenge for proteostasis because the majority of lysosomal degradation machinery is present in the cell soma. In recent years, however, mature lysosomes were identified in dendrites, and a fraction
Externí odkaz:
https://doaj.org/article/c3054975b675454d8630ed3d26b78003
Autor:
Martyna M. Grochowska, Federico Ferraro, Ana Carreras Mascaro, Domenico Natale, Amber Winkelaar, Valerie Boumeester, Guido J. Breedveld, Vincenzo Bonifati, Wim Mandemakers
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/e390fc4c883e438a9d69c40e5ea15425
Autor:
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It ha
Externí odkaz:
https://doaj.org/article/8050b454059242799298a70205d8078a
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene
Externí odkaz:
https://doaj.org/article/89f3917176054208a268f29737d840f6
Autor:
Ana Carreras Mascaro, Martyna M. Grochowska, Valerie Boumeester, Natasja F. J. Dits, Ece Naz Bilgiҫ, Guido J. Breedveld, Leonie Vergouw, Frank Jan de Jong, Martin E. van Royen, Vincenzo Bonifati, Wim Mandemakers
Autosomal dominant variants inLRP10have been identified in patients with Lewy body diseases (LBDs), including Parkinson’s disease (PD), Parkinson’s disease-dementia (PDD), and dementia with Lewy bodies (DLB). Nevertheless, there is little mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b4b6b6a8f57db63c217e1b584135c9
https://doi.org/10.1101/2023.05.12.540510
https://doi.org/10.1101/2023.05.12.540510
Akademický článek
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Autor:
Maria Andres-Alonso, Katarzyna M. Grochowska, Eckart D. Gundelfinger, Anna Karpova, Michael R. Kreutz
Publikováno v:
Molecular and cellular neuroscience 125, 103854 (2023). doi:10.1016/j.mcn.2023.103854
The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708faf9276945b4ccd6be28ce138ca5a
Autor:
Katarzyna M Grochowska, Guilherme M Gomes, Rajeev Raman, Rahul Kaushik, Liudmila Sosulina, Hiroshi Kaneko, Anja M Oelschlegel, PingAn Yuanxiang, Irene Reyes‐Resina, Gonca Bayraktar, Sebastian Samer, Christina Spilker, Marcel S Woo, Markus Morawski, Jürgen Goldschmidt, Manuel A Friese, Steffen Rossner, Gemma Navarro, Stefan Remy, Carsten Reissner, Anna Karpova, Michael R Kreutz
Publikováno v:
The EMBO journal, 42(4):e112453
The EMBO journal 42(4), e112453 (2023). doi:10.15252/embj.2022112453
The EMBO journal 42(4), e112453 (2023). doi:10.15252/embj.2022112453
Synaptic dysfunction caused by soluble β-amyloid peptide (Aβ) is a hallmark of early-stage Alzheimer's disease (AD), and is tightly linked to cognitive decline. By yet unknown mechanisms, Aβ suppresses the transcriptional activity of cAMP-responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b4e66e4bdf94453ba2c55d601ee9d1
https://www.embopress.org/doi/full/10.15252/embj.2022112453#support-information-section
https://www.embopress.org/doi/full/10.15252/embj.2022112453#support-information-section
Autor:
Martyna M. Grochowska, Federico Ferraro, Ana Carreras Mascaro, Domenico Natale, Amber Winkelaar, Valerie Boumeester, Guido J. Breedveld, Vincenzo Bonifati, Wim Mandemakers
Astrocytes are the most populous cell type of the human central nervous system and are essential for physiological brain function. Increasing evidence suggests multiple roles for astrocytes in Parkinson’s disease (PD), nudging a shift in the resear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201008125022c7c0c9f6e33b1f16a0b0
https://doi.org/10.1101/2022.11.08.515628
https://doi.org/10.1101/2022.11.08.515628
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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