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Akademický článek

Sleep disturbances are associated with irritability in ASD children with sensory sensitivities

Autor: Alona Molcho-Haimovich, Liat Tikotzky, Gal Meiri, Michal Ilan, Analya Michaelovski, Hen Schtaierman, Hava M. Golan, Yair Sadaka, Idan Menashe, Ilan Dinstein

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 15, Iss 1, Pp 1-10 (2023)

Abstract Background Parent reports suggest that 44–84% of children with ASD exhibit sleep disturbances that are of clinical concern. Previous studies have reported that, in children with ASD, the severity of sleep disturbances is associated with th

Externí odkaz: https://doaj.org/article/9b8165a72e0644449264de8d9a6289bf

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Akademický článek

Temporal dynamics of isolation calls emitted by pups in environmental and genetic mouse models of autism spectrum disorder

Autor: Ayelet Gal, Eynav Raykin, Shaked Giladi, Dror Lederman, Ora Kofman, Hava M. Golan

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

IntroductionEnvironmental and genetic factors contribute to the increased risk for neurodevelopmental disorders, including deficits in the development of social communication. In the mouse, ultrasonic vocalizations emitted by the pup stimulate matern

Externí odkaz: https://doaj.org/article/675cf58b02ba40a4904c26c0fdf50638

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Akademický článek

Genetic impairment of folate metabolism regulates cortical interneurons and social behavior

Autor: Noa Sadigurschi, Gilad Scrift, Johannes Hirrlinger, Hava M. Golan

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

IntroductionThe implications of folate deficiency in neuropsychiatric disorders were demonstrated in numerous studies. Genetic deficiency in a key folate metabolism enzyme, MTHFR, is an example of the interaction between genetic and environmental ris

Externí odkaz: https://doaj.org/article/f16d7cdf9ed54f3881fa447c5c85791b

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Akademický článek

Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism

Autor: Itay Shekel, Shaked Giladi, Eynav Raykin, May Weiner, Vered Chalifa-Caspi, Dror Lederman, Ora Kofman, Hava M. Golan

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Studies in rodent models suggest that calls emitted by isolated pups serve as an early behavioral manifestation of communication deficits and autistic like behavior. Previous studies in our labs showed that gestational exposure to the pesticide chlor

Externí odkaz: https://doaj.org/article/2eb0f174c9934c3ba3a1a53fc8fbc456

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Akademický článek

Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice

Autor: Ayelet Orenbuch, Keren Fortis, Siraphat Taesuwan, Raz Yaffe, Marie A. Caudill, Hava M. Golan

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

The causes and contributing factors of autism spectrum disorders (ASD) are poorly understood. One gene associated with increased risk for ASD is methylenetetrahydrofolate-reductase (MTHFR), which encodes a key enzyme in one carbon (C1) metabolism. Th

Externí odkaz: https://doaj.org/article/03431facc24c46c1a9f5618b3f5ef93e

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