Zobrazeno 1 - 10
of 197
pro vyhledávání: '"M, Glavas"'
Autor:
Sandra Pereira, Daemon L. Cline, Melissa Chan, Kalin Chai, Ji Soo Yoon, Shannon M. O’Dwyer, Cara E. Ellis, Maria M. Glavas, Travis D. Webber, Robert K. Baker, Suheda Erener, Scott D. Covey, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodolog
Externí odkaz:
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
Autor:
Maria M. Glavas, Queenie Hui, Ian Miao, Fan Yang, Suheda Erener, Kacey J. Prentice, Michael B. Wheeler, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the pr
Externí odkaz:
https://doaj.org/article/4dfa192eb736486bb29246613caa1b5a
Autor:
Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O’Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blüher, Hana Algül, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100434- (2021)
Summary: miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of mi
Externí odkaz:
https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f
Autor:
Eva Tudurí, Maria M. Glavas, Ali Asadi, Robert K. Baker, Cara E. Ellis, Galina Soukhatcheva, Marjolaine Philit, Frank K. Huynh, James D. Johnson, C. Bruce Verchere, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract The study of primary glucagon-secreting α-cells is hampered by their low abundance and scattered distribution in rodent pancreatic islets. We have designed a double-stranded adeno-associated virus containing a rat proglucagon promoter (700
Externí odkaz:
https://doaj.org/article/556a5308d1314702b2cd07d70fc68443
Autor:
Paul V. Sabatini, Thilo Speckmann, Cuilan Nian, Maria M. Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, A.M. James Shapiro, William T. Gibson, C. Bruce Verchere, Francis C. Lynn
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 163-174 (2018)
Summary: Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene expression. These processes, along with the restoration of resting membrane potential, are energy intensive. We hypothesized t
Externí odkaz:
https://doaj.org/article/7b8849adfc394379875cec3389786339
Publikováno v:
Molecular Metabolism, Vol 6, Iss 9, Pp 1052-1065 (2017)
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin o
Externí odkaz:
https://doaj.org/article/3e561b5b01694290bc4720cafb90aebc
Autor:
Heather C. Denroche, Michelle M. Kwon, Maria M. Glavas, Eva Tudurí, Marion Philippe, Whitney L. Quong, Timothy J. Kieffer
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 716-724 (2016)
Objective: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown a
Externí odkaz:
https://doaj.org/article/9adeb592199c49e99800855a91ccf265
Autor:
Melissa Chan, Shannon O'Dwyer, Kalin Chai, Sandra Pereira, Suheda Erener, Daemon L. Cline, Timothy J. Kieffer, Travis D. Webber, Scott D. Covey, Robert K. Baker, Cara E. Ellis, Maria M. Glavas, Ji Soo Yoon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodology to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48f93a5f68f04908f43db82628bb63b
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
Autor:
Ian Miao, Timothy J. Kieffer, Ann Y. Lee, Mojibian Majid, Shannon O'Dwyer, Maria M. Glavas, Fan Yang
Publikováno v:
Diabetes
We previously demonstrated that male, but not female, Swiss Webster mice are susceptible to diabetes, with incidence increased by early overnutrition and high-fat diet (HFD). In this study, we investigated how HFD in Swiss Webster males and females d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b1400484d129acad1e4c036e18f23c
http://europepmc.org/articles/PMC8660987
http://europepmc.org/articles/PMC8660987
Autor:
M. Glavas-Dodov, M. Simonoska-Crcarevska, R. Slavevska Raicki, N. Sibinovska, K. Mladenovska, A. Zafirovska-Gapkovska
Publikováno v:
Makedonsko Farmacevtski Bilten, Vol 60, Iss (2), Pp 57-65 (2014)
In our previous work Box-Behnken experimental design was applied for formulation optimization of the thermoreversible mucoadhesive in situ vaginal hydrogels with propolis and optimized batches were identified. Optimized batches of bioartificial polym
Externí odkaz:
https://doaj.org/article/4f9702e69df448478056e0e693081401