Zobrazeno 1 - 10 of 240 pro vyhledávání: '"M, Ghia"'
1
Akademický článek
A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer
Autor: Rebecca A. Shatsky, Hemali Batra-Sharma, Teresa Helsten, Richard B. Schwab, Emily I. Pittman, Minya Pu, Elizabeth Weihe, Emanuela M. Ghia, Laura Z. Rassenti, Alfredo Molinolo, Betty Cabrera, James B. Breitmeyer, George F. Widhopf, Karen Messer, Catriona Jamieson, Thomas J. Kipps, Barbara A. Parker
Publikováno v: Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Zilovertamab is a humanized monoclonal antibody targeting ROR1, an onco-embryonic antigen expressed by malignant cells of a variety of solid tumors, including breast cancer. A prior phase 1 study showed that zilovertamab was well
Externí odkaz: https://doaj.org/article/0486bdf60d074a82b6fba59959ed172b
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2
Akademický článek
Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia
Autor: Manoj Kumar Kashyap, Hiren Karathia, Deepak Kumar, Roberto Vera Alvarez, Jose Vicente Forero-Forero, Eider Moreno, Juliana Velez Lujan, Carlos Ivan Amaya-Chanaga, Newton Medeiros Vidal, Zhe Yu, Emanuela M. Ghia, Paula A. Lengerke-Diaz, Daniel Achinko, Michael Y. Choi, Laura Z. Rassenti, Leonardo Mariño-Ramírez, Stephen M. Mount, Sridhar Hannenhalli, Thomas J. Kipps, Januario E. Castro
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102202- (2024)
Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of s
Externí odkaz: https://doaj.org/article/adf59c81f6f94126a63b606708311ab5
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3
Akademický článek
Melanoma and CLL co-occurrence and survival: role of KC history
Autor: Yayi Zhao, Rossybelle P. Amorrortu, Sandra C. Stewart, Kavita M. Ghia, Vonetta L. Williams, Vernon K. Sondak, Kenneth Y. Tsai, Javier Pinilla-Ibarz, Julio C. Chavez, Dana E. Rollison
Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Survival following melanoma and chronic lymphocytic leukemia (CLL) have both been individually associated with previous history of non-melanoma skin cancers (specifically keratinocyte carcinomas [KC]). Furthermore, melanoma and CL
Externí odkaz: https://doaj.org/article/912aba85db254f82913409630562e1b2
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4
Akademický článek
Examining disparities in large‐scale patient‐reported data capture using digital tools among cancer patients at clinical intake
Autor: Dana E. Rollison, Brian D. Gonzalez, Kea Turner, Heather S. L. Jim, Yayi Zhao, Rossybelle P. Amorrortu, Rachel Howard, Kavita M. Ghia, Bryan Ngo, Phillip Reisman, Colin Moore, Randa Perkins, Robert J. Keenan, David A. Sallman, Cristina M. Naso, Edmondo J. Robinson, Susan T. Vadaparampil, Vani N. Simmons, Matthew B. Schabath, Scott M. Gilbert
Publikováno v: Cancer Medicine, Vol 12, Iss 18, Pp 19033-19046 (2023)
Abstract Background Patient‐reported data can improve quality of healthcare delivery and patient outcomes. Moffitt Cancer Center (“Moffitt”) administers the Electronic Patient Questionnaire (EPQ) to collect data on demographics, including sexua
Externí odkaz: https://doaj.org/article/f152c0a7fc304aa4ba295dbe3c599625
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6
Akademický článek
Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia
Autor: Matthew Kaufman, Xiao-Jie Yan, Wentian Li, Emanuela M. Ghia, Anton W. Langerak, Laura Z. Rassenti, Chrysoula Belessi, Neil E. Kay, Frederic Davi, John C. Byrd, Sarka Pospisilova, Jennifer R. Brown, Mark Catherwood, Zadie Davis, David Oscier, Marco Montillo, Livio Trentin, Richard Rosenquist, Paolo Ghia, Jacqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Kostas Stamatopoulos, Thomas J. Kipps, Donna Neuberg, Nicholas Chiorazzi
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells
Externí odkaz: https://doaj.org/article/c619ded3a3974ed5becc2e624f138274
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