Zobrazeno 1 - 10
of 182
pro vyhledávání: '"M, Gellai"'
Publikováno v:
Molecular and Cellular Biochemistry. 197:53-59
Neutral endopeptidase (NEP, 24.11) is an ectoenzyme involved in the degradation of peptide hormones such as endothelin (ET), atrial natriuretic factor and enkephalins. The current study was designed to assess the involvement of NEP in ischemia-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe71b2a29a8c26f59d3e388a54e502cd
https://doi.org/10.1023/a:1006913103720
https://doi.org/10.1023/a:1006913103720
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:S322-325
Binding studies performed in dog kidney, lung, and spleen using [125I]endothelin (ET) 3 and a series of ETB-selective ligands indicated the presence of two subtypes of ETB receptors, an IRL-1620-sensitive (putative ETB1) and an IRL-1620-insensitive (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b8e29325d13da475dd68ae77548152
https://doi.org/10.1097/00005344-199526003-00097
https://doi.org/10.1097/00005344-199526003-00097
Autor:
D. E. Allen, M. Gellai
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 265:R689-R696
Renal alpha 2-adrenoreceptors modulate the hydrosmotic action of arginine vasopressin (AVP) through suppression of AVP-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) accumulation. Circulating catecholamines, likely candidates for the endogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834eba0f6390dc7d4487449bd7ccdb29
https://doi.org/10.1152/ajpregu.1993.265.3.r689
https://doi.org/10.1152/ajpregu.1993.265.3.r689
Publikováno v:
Fundamental & Clinical Pharmacology. 5:25-38
The mechanism(s) responsible for arterial vasodilation observed following acute administration of racemic carvedilol, a novel vasodilator/beta adrenoceptor antagonist, has been investigated in rats. In conscious spontaneously hypertensive rats, carve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bca3656ed3a818d8517f046257c03d
https://doi.org/10.1111/j.1472-8206.1991.tb00698.x
https://doi.org/10.1111/j.1472-8206.1991.tb00698.x
Autor:
D. E. Allen, M. Gellai
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 258:R1034-R1041
We evaluated the effects of leukotrienes (LTs) C4 and D4 on systemic and renal hemodynamics in conscious rats. Intravenous injections of LTC4 or LTD4 (0.5-10 micrograms/kg) caused dose-dependent decreases in cardiac output (CO), renal blood flow (RBF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755dbf95a21e50dbc464b031cfbef876
https://doi.org/10.1152/ajpregu.1990.258.4.r1034
https://doi.org/10.1152/ajpregu.1990.258.4.r1034
Publikováno v:
European Journal of Clinical Pharmacology. 38:S82-S88
Carvedilol is a potent antihypertensive agent with a dual mechanism of action. At relatively low concentrations it is a competitive β-adrenoceptor antagonist and a vasodilator, whereas at higher concentrations it is also a calcium channel antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e2a7469447ea5f8d84327fa6fde76a
https://doi.org/10.1007/bf01409471
https://doi.org/10.1007/bf01409471
Publikováno v:
Biochemical and Biophysical Research Communications. 241:212-214
In this study, the involvement of osteopontin in a rat model of ischemia-induced acute renal failure (ARF) was evaluated. In unilaterally nephrectomized Sprague Dawley rats where the left artery was occluded for 30 min., plasma creatinine levels incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9a483486086de3d304927f9d24ff80
https://doi.org/10.1006/bbrc.1997.7791
https://doi.org/10.1006/bbrc.1997.7791
Publikováno v:
Molecular and cellular biochemistry. 197(1-2)
Neutral endopeptidase (NEP, 24.11) is an ectoenzyme involved in the degradation of peptide hormones such as endothelin (ET), atrial natriuretic factor and enkephalins. The current study was designed to assess the involvement of NEP in ischemia-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67b3c04a0d8e320e7ee6df06cc9a7a92
https://pubmed.ncbi.nlm.nih.gov/10485324
https://pubmed.ncbi.nlm.nih.gov/10485324
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(3)
Administration of the selective adenosine A1 receptor antagonist, CVT-124, to conscious chronically instrumented rats resulted in significant increases in urine flow rate and sodium excretion without affecting potassium excretion or renal hemodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5334b3aed1460108ba262a274c0428f
https://pubmed.ncbi.nlm.nih.gov/9732378
https://pubmed.ncbi.nlm.nih.gov/9732378
Autor:
E H, Ohlstein, P, Nambi, D W, Hay, M, Gellai, D P, Brooks, J, Luengo, J N, Xiang, J D, Elliott
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(2)
The present study describes the pharmacological profile of ((E)-alpha-[[1-butyl-5-[2-[(2-carboxyphenyl)methoxy]-4-methoxy-phenyl ]-1H-pyrazol-4-yl]methlene]-6-methoxy-1,3-benzodioxole-5-propanoic acid) (SB 234551), a high-affinity, nonpeptide endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c789f22a37eae123c8957cddfc1f742
https://pubmed.ncbi.nlm.nih.gov/9694916
https://pubmed.ncbi.nlm.nih.gov/9694916