Zobrazeno 1 - 10
of 28
pro vyhledávání: '"M, Gamberdella"'
Autor:
Nicholas A. Meanwell, John W. Russell, S. M. Seiler, Piyasena Hewawasam, Wright John J, J. A. Thomas, George B. Zavoico, M. Gamberdella, Harold Goldenberg
Publikováno v:
ChemInform. 25
Autor:
Marianne E. Federici, Karen S. Hartl, M. J. Rosenfeld, Nicholas A. Meanwell, S. M. Seiler, M. Gamberdella, C.L. Brassard, George B. Zavoico, Wright John J, J.O. Buchanan, J. S. Fleming
Publikováno v:
ChemInform. 25
Autor:
Wright John J, H. R. Roth, Dennis Rd, Michael J. Rosenfeld, E. Gillespie, J.O. Buchanan, C.L. Brassard, Nicholas A. Meanwell, M. Gamberdella, E. C. R. Smith
Publikováno v:
Journal of Medicinal Chemistry. 35:2688-2696
Two series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives incorporating an additional site for acid salt formation were synthesized and evaluated as inhibitors of human blood platelet cAMP phosphodiesterase (PDE) and ADP-induced platelet
Autor:
J.O. Buchanan, William A. Schumacher, J. Stuart Fleming, M. Gamberdella, Steven M. Seiler, George B. Zavoico, Nicholas A. Meanwell
Publikováno v:
Thrombosis research. 74(2)
The oral activity and antithrombotic efficacy of BMY 42393 was examined in ex vivo platelet aggregation studies and arterial thrombosis animal models. In a heterologous ex vivo platelet aggregation assay, ADP-induced human platelet aggregation was in
Autor:
N A, Meanwell, M J, Rosenfeld, A K, Trehan, J J, Wright, C L, Brassard, J O, Buchanan, M E, Federici, J S, Fleming, M, Gamberdella, K S, Hartl
Publikováno v:
Drug design and discovery. 11(1)
2-[3-[2-(4,5-Diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid, 1, has been described as a non-prostanoid PGI2 mimetic that demonstrates anti-thrombotic properties of long duration in animal models of thrombosis. The effects of substitution and modificat
Autor:
Marianne E. Federici, C.L. Brassard, Michael J. Rosenfeld, Karen S. Hartl, Nicholas A. Meanwell, M. Gamberdella, J.O. Buchanan, George B. Zavoico, J. S. Fleming, Wright John J
Publikováno v:
Journal of medicinal chemistry. 36(24)
The 4,5-diphenyloxazole derivatives 2-4 were previously identified as nonprostanoid prostacyclin (PGI2) mimetics. A series of derivatives of 2-4 bearing substitutents at the carbon atom alpha to the oxazole ring were synthesized and evaluated as inhi
Autor:
John W. Russell, J. A. Thomas, George B. Zavoico, Piyasena Hewawasam, M. Gamberdella, Harold Goldenberg, Wright John J, Nicholas A. Meanwell, S. M. Seiler
Publikováno v:
Journal of medicinal chemistry. 36(22)
1-(Cyclohexylmethyl)-4-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b] quinolin-7-yl)oxy]-1-oxobutyl]piperazine (2) was previously identified as a potent, water-soluble inhibitor of human blood platelet cAMP phosphodiesterase and of induced aggregation in v
Autor:
J. Stuart Fleming, Jeffrey L. Romine, J.O. Buchanan, George B. Zavoico, Ashok K. Trehan, Steven M. Seiler, Michael J. Rosenfeld, C.L. Brassard, Marianne E. Federici, J. J. Kim Wright, Nicholas A. Meanwell, M. Gamberdella
Publikováno v:
Journal of medicinal chemistry. 35(19)
4,5-Diphenyl-2-oxazolenonanoic acid (2) and 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (3) were previously identified as nonprostanoid prostacyclin (PGI2) mimetics that inhibit ADP-induced aggregation of human platelets in vitro. The
Autor:
N A, Meanwell, M J, Rosenfeld, A K, Trehan, J J, Wright, C L, Brassard, J O, Buchanan, M E, Federici, J S, Fleming, M, Gamberdella, G B, Zavoico
Publikováno v:
Journal of medicinal chemistry. 35(19)
4,5-Diphenyl-2-oxazolenonanoic acid (18b) was synthesized and found to inhibit ADP-induced aggregation of human platelets with an IC50 of 2.5 microM. Acid 18b displaced [3H]iloprost from human platelet membranes in a concentration-dependent fashion,
Autor:
E. Gillespie, D. L. Wedding, E. C. R. Smith, M. Gamberdella, Nicholas A. Meanwell, Bradley C. Pearce, J.O. Buchanan, U.M. Baryla, H. R. Roth, Wright John J
Publikováno v:
Journal of medicinal chemistry. 35(14)
A series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives, substituted at the 7-position with functionalized side chains, was synthesized and evaluated as inhibitors of human blood platelet cAMP phosphodiesterase (PDE) as well as ADP- and c