Zobrazeno 1 - 10
of 139
pro vyhledávání: '"M, Frojmovic"'
Publikováno v:
British Journal of Haematology. 112:1055-1061
Exposure of whole blood (WB) to subendothelial extracellular matrix (ECM) under shear stress in the cone and plate(let) analyser (CPA) results in platelet adhesion, followed by release reaction and aggregation of circulating platelets on the adherent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b66d0d0afe867d00de9d1adfd49a11
https://doi.org/10.1046/j.1365-2141.2001.02657.x
https://doi.org/10.1046/j.1365-2141.2001.02657.x
Publikováno v:
Journal of Biological Chemistry. 276:5605-5612
Thrombospondin-1 (TSP) may, after secretion from platelet alpha granules, participate in platelet aggregation, but its mode of action is poorly understood. We evaluated the capacity of TSP to form inter-platelet cross-bridges through its interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8480441f81caa8d98337f243ad4ce80a
https://doi.org/10.1074/jbc.m010091200
https://doi.org/10.1074/jbc.m010091200
Publikováno v:
Biophysical Journal. 78(3):1195-1206
We studied the shear-induced breakup of doublets of aldehyde/sulfate (A/S) latex spheres covalently linked with purified platelet GPIIb-IIIa receptor, and cross-linked by fibrinogen. Flow cytometry with fluorescein isothiocyanate-fibrinogen showed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89b4e940a22ca04d095aab7d889bbf2
Publikováno v:
Platelets. 11:99-110
Although platelet cross-bridging is mediated primarily by the binding of fibrinogen to its activated membrane receptor, glycoprotein (GP) IIb-IIIa*, such an interaction may not be sufficient to support the aggregation process. As this question could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e830df7e7a88a1470a7d0f8232c4500f
https://doi.org/10.1080/09537100075715
https://doi.org/10.1080/09537100075715
Publikováno v:
Thrombosis and Haemostasis. 81:967-975
SummaryPrevious studies evaluating requirements for occupancy of thrombin receptors in normal platelet secretion and aggregation, using the thrombin antagonists hirudin and PPACK (D-Phe-Pro-Arg-chloromethylke-tone), have suggested that at low thrombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568404c054f7ab96a81fb193a45a0ebe
https://doi.org/10.1055/s-0037-1614608
https://doi.org/10.1055/s-0037-1614608
Publikováno v:
Platelets. 10:407-416
Recent studies have suggested that the platelet fibrinogen (Fg) receptor, platelet membrane glycoprotein IIbIIIa (GPIIbIIIa, or integrin alpha(IIb)beta(3)) is also an adenosine triphosphate (ATP) binding site, and that the binding of ATP can directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab22e352fd714f0c44ff680d0ff2721c
https://doi.org/10.1080/09537109975889
https://doi.org/10.1080/09537109975889
Autor:
Mony M. Frojmovic, Qingde Liu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1429:217-229
The carboxyl terminus of the fibrinogen (Fg) gamma chain (gamma400-411) is necessary and sufficient to support platelet aggregation and adhesion. However, a monoclonal antibody (mAb) to the Fg RIBS-I epitope (gamma373-385), the anti-Fg-RIBS-I, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418265fce88bb0a7de6a707c17a8e0f8
https://doi.org/10.1016/s0167-4838(98)00235-0
https://doi.org/10.1016/s0167-4838(98)00235-0
Autor:
Ana Kasirer-Friede, Mony M. Frojmovic
Publikováno v:
Thrombosis and Haemostasis. 80:428-436
SummaryWe recently reported that washed platelets (WP) activated with ADP and expressing surface-bound vWF aggregated in flow through small tubes or in a cylindrical couette device at physiological shear rates of G = 300 s–1-1000 s–1 in the absen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd6e911dfc20386e3e0afa10eef82392
https://doi.org/10.1055/s-0037-1615225
https://doi.org/10.1055/s-0037-1615225
Publikováno v:
Thrombosis and Haemostasis. 77:568-576
SummaryWe previously showed that ADP activation of washed human platelets in plasma-free suspensions supports aggregation at moderate shear stress (0.4-1.6 Nm-2) in Poiseuille flow. Although most activated platelets expressed maximal fibrinogen-occup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e30144bbd94d2ace4c27263b2ef634b
https://doi.org/10.1055/s-0038-1656007
https://doi.org/10.1055/s-0038-1656007
Publikováno v:
British Journal of Haematology. 93:204-214
Dynamic and quantitative studies of the binding of fibrinogen (Fg) to its receptor, GPIIb-IIIa, on activated platelets, leading to platelet aggregation, are best studied with fluorescently-labelled Fg by flow cytometry. Due to conflicting reports on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4a78bb19da920fe94834edb1e1c4bc
https://doi.org/10.1046/j.1365-2141.1996.445980.x
https://doi.org/10.1046/j.1365-2141.1996.445980.x