Zobrazeno 1 - 10
of 677
pro vyhledávání: '"M, Frier"'
Autor:
Qinyu Hao, Minxue Liu, Swapna Vidhur Daulatabad, Saba Gaffari, You Jin Song, Rajneesh Srivastava, Shivang Bhaskar, Anurupa Moitra, Hazel Mangan, Elizabeth Tseng, Rachel B Gilmore, Susan M Frier, Xin Chen, Chengliang Wang, Sui Huang, Stormy Chamberlain, Hong Jin, Jonas Korlach, Brian McStay, Saurabh Sinha, Sarath Chandra Janga, Supriya G Prasanth, Kannanganattu V Prasanth
Publikováno v:
eLife, Vol 13 (2024)
Out of the several hundred copies of rRNA genes arranged in the nucleolar organizing regions (NOR) of the five human acrocentric chromosomes, ~50% remain transcriptionally inactive. NOR-associated sequences and epigenetic modifications contribute to
Externí odkaz:
https://doaj.org/article/125bf24a87b9450d9f1f38fca36d642a
Autor:
Emily M. Frier, Chun Lin, Rebecca M. Reynolds, Karel Allegaert, Jasper V. Been, Abigail Fraser, Mika Gissler, Kristjana Einarsdóttir, Lani Florian, Bo Jacobsson, Joshua P. Vogel, Helga Zoega, Sohinee Bhattacharya, Eyal Krispin, Lars Henning Pedersen, Devender Roberts, Stefan Kuhle, John Fahey, Ben W. Mol, David Burgner, Ewoud Schuit, Aziz Sheikh, Rachael Wood, Cynthia Gyamfi-Bannerman, Jessica E. Miller, Kate Duhig, Marius Lahti-Pulkkinen, Eran Hadar, John Wright, Sarah R. Murray, Sarah J. Stock
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Background Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of women given ACS give birth ou
Externí odkaz:
https://doaj.org/article/80c01b3ffe044b1296ac717c3f4cbb8f
Autor:
Sheila M. Grecian, Stela McLachlan, Jonathan A. Fallowfield, Peter C. Hayes, Indra Neil Guha, Joanne R. Morling, Stephen Glancy, Rachel M. Williamson, Rebecca M. Reynolds, Brian M. Frier, Nicola N. Zammitt, Jackie F. Price, Mark W. J. Strachan
Publikováno v:
Obesity Science & Practice, Vol 7, Iss 5, Pp 497-508 (2021)
Abstract Background Type 2 diabetes (T2D) is associated with increased risk of progression to cirrhosis and hepatocellular carcinoma (HCC) in people with chronic liver diseases, particularly non‐alcoholic fatty liver disease (NAFLD). However, the a
Externí odkaz:
https://doaj.org/article/1a7b4534a35442b38ce9ffd656a2d923
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Throughout history, up to the early part of the 20th century, diabetes has been a devastating disorder, particularly when diagnosed in childhood when it was usually fatal. Consequently, the successful pancreatic extraction of insulin in 1921 was a mi
Externí odkaz:
https://doaj.org/article/05e1c4fb22ff41cab024697a1800f078
Autor:
Radzi M. Noh, Alex J. Graveling, Ninian N. Lang, Audrey C. White, Kuan Ken Lee, Nicholas L. Mills, David E. Newby, Chim C. Lang, Brian M. Frier
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 3, Pp n/a-n/a (2021)
Abstract Aims This study examined the effect of experimentally‐induced hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with, and without, type 1 diabetes. Methods In a prospective, randomised, open‐label, blinde
Externí odkaz:
https://doaj.org/article/3d4dd065f8044592800f3ce6393d83ec
Autor:
Xiao Ling Li, Murugan Subramanian, Matthew F. Jones, Ritu Chaudhary, Deepak K. Singh, Xinying Zong, Berkley Gryder, Sivasish Sindri, Min Mo, Aaron Schetter, Xinyu Wen, Swetha Parvathaneni, Dickran Kazandjian, Lisa M. Jenkins, Wei Tang, Fathi Elloumi, Jennifer L. Martindale, Maite Huarte, Yuelin Zhu, Ana I. Robles, Susan M. Frier, Frank Rigo, Maggie Cam, Stefan Ambs, Sudha Sharma, Curtis C. Harris, Mary Dasso, Kannanganattu V. Prasanth, Ashish Lal
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2408-2423 (2017)
Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear
Externí odkaz:
https://doaj.org/article/44875ca0858a47c68888951b9611cf2c
Autor:
Huan Wang, Peter T. Donnan, Callum J. Leese, Edward Duncan, David Fitzpatrick, Brian M. Frier, Graham P. Leese
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 3, Iss 1, Pp 1-8 (2017)
Abstract Background Almost 20 years ago, the frequencies of severe hypoglycemia requiring emergency medical treatment were reported in people with types 1 and 2 diabetes in the Tayside region of Scotland. With subsequent improvements in the treatment
Externí odkaz:
https://doaj.org/article/4f25260d06a64a1ebb15330370cf78b1
Publikováno v:
Primary Care Diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e161589698994de1ab54d366bc315473
https://doi.org/10.1016/j.pcd.2023.04.010
https://doi.org/10.1016/j.pcd.2023.04.010
Autor:
Ernesto Maddaloni, Geremia B. Bolli, Brian M. Frier, Randie R. Little, Richard D. Leslie, Paolo Pozzilli, Raffaela Buzzetti
Publikováno v:
Diabetes, Obesity and Metabolism. 24:1912-1926
Impaired beta-cell function is a recognized cornerstone of diabetes pathophysiology. Estimates of insulin secretory capacity are useful to inform clinical practice, helping to classify types of diabetes, complication risk stratification and to guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44427de7c83cc60bb0770a50772f645d
https://doi.org/10.1111/dom.14785
https://doi.org/10.1111/dom.14785
Autor:
Julie Settles, Hong Kan, Christopher J. Child, Magdaliz Gorritz, Jasjit K. Multani, Catherine B. McGuiness, Rolin L. Wade, Brian M. Frier
Publikováno v:
Diabetes, Obesity and Metabolism. 24:1235-1244
Several risk factors for severe hypoglycaemia (SH) are associated with insulin-treated diabetes. This study explored potential risk factors in adults with insulin-treated type 2 diabetes mellitus (T2DM).In this case-control study, adults with T2DM in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d472d4e4c83ca4be83103ea38e8d35eb
https://doi.org/10.1111/dom.14690
https://doi.org/10.1111/dom.14690