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Akademický článek

Laponite for biomedical applications: An ophthalmological perspective

Autor: Maria J. Rodrigo, Maria J. Cardiel, Jose M. Fraile, Jose A. Mayoral, Luis E. Pablo, Elena Garcia-Martin

Publikováno v: Materials Today Bio, Vol 24, Iss , Pp 100935- (2024)

Clay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Laponite applic

Externí odkaz: https://doaj.org/article/822a925ecb3a4d66ac5a4a449c874fd3

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Akademický článek

USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy

Autor: Diana Campos-Iglesias, Julia M. Fraile, Gabriel Bretones, Alejandro A. Montero, Elena Bonzon-Kulichenko, Jesús Vázquez, Carlos López-Otín, José M. P. Freije

Publikováno v: Cell Death and Disease, Vol 14, Iss 1, Pp 1-7 (2023)

Abstract The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability. Deubiquitinases have emerged as key regulators of the SAC, mainly by determ

Externí odkaz: https://doaj.org/article/494225a6be484efc921f890a1b484580

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Akademický článek

Long-term evolution of the neutron rate at the Canfranc Underground Laboratory

Autor: S. E. A. Orrigo, J. L. Tain, N. Mont-Geli, A. Tarifeño-Saldivia, L. M. Fraile, M. Grieger, J. Agramunt, A. Algora, D. Bemmerer, F. Calviño, G. Cortés, A. De Blas, I. Dillmann, A. Domínguez Bugarín, R. García, E. Nacher, A. Tolosa-Delgado

Publikováno v: European Physical Journal C: Particles and Fields, Vol 82, Iss 9, Pp 1-11 (2022)

Abstract We report results on the long-term variation of the neutron counting rate at the Canfranc Underground Laboratory, of importance for several low-background experiments installed there, including rare-event searches. The measurement campaign w

Externí odkaz: https://doaj.org/article/4bb197deaa034bfb8de84f4c8a8115d7

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Akademický článek

In vivo production of fluorine-18 in a chicken egg tumor model of breast cancer for proton therapy range verification

Autor: Samuel España, Daniel Sánchez-Parcerisa, Paloma Bragado, Álvaro Gutiérrez-Uzquiza, Almudena Porras, Carolina Gutiérrez-Neira, Andrea Espinosa, Víctor V. Onecha, Paula Ibáñez, Víctor Sánchez-Tembleque, José M. Udías, Luis M. Fraile

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Range verification of clinical protontherapy systems via positron-emission tomography (PET) is not a mature technology, suffering from two major issues: insufficient signal from low-energy protons in the Bragg peak area and biological washou

Externí odkaz: https://doaj.org/article/d83a2bc1a5274f1d971a315d88f8e44a

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