Zobrazeno 1 - 10
of 1 619
pro vyhledávání: '"M, Fortin"'
Autor:
Lauren N. Woodie, Lily C. Melink, Ahren J. Alberto, Michelle Burrows, Samantha M. Fortin, Calvin C. Chan, Matthew R. Hayes, Mitchell A. Lazar
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101861- (2024)
Objective: The dorsal vagal complex (DVC) of the hindbrain is a major point of integration for central and peripheral signals that regulate a wide variety of metabolic functions to maintain energy balance. The REV-ERB nuclear receptors are important
Externí odkaz:
https://doaj.org/article/14719a0d6d7f4ff18ad68304b5f7c16d
Publikováno v:
F1000Research, Vol 12 (2023)
In modern society, there is a growing population affected by circadian clock disruption through night shift work, artificial light-at-night exposure, and erratic eating patterns. Concurrently, the rate of cancer incidence in individuals under the age
Externí odkaz:
https://doaj.org/article/46483db7248944148d8e1af2296c46c3
Autor:
Vicky Mody, Joanna Ho, Savannah Wills, Ahmed Mawri, Latasha Lawson, Maximilian C. C. J. C. Ebert, Guillaume M. Fortin, Srujana Rayalam, Shashidharamurthy Taval
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Here, the authors identify potential drugs that target 3-chymotrypsin like protease (3CLpro), which is a pivotal protease for the replication of SARS-CoV-2. They found that off-target inhibitors such as ivermectin and micafungin inhibit 3CLpro enzyme
Externí odkaz:
https://doaj.org/article/e6979cbcb60044b5b4d28c086944625c
Autor:
Michael I Dorrell, Heidi R Kast-Woelbern, Ryan T Botts, Stephen A Bravo, Jacob R Tremblay, Sarah Giles, Jessica F Wada, MaryAnn Alexander, Eric Garcia, Gabriel Villegas, Caylor B Booth, Kaitlyn J Purington, Haylie M Everett, Erik N Siles, Michael Wheelock, Jordan A Silva, Bridget M Fortin, Connor A Lowey, Allison L Hale, Troy L Kurz, Jack C Rusing, Dawn M Goral, Paul Thompson, Alec M Johnson, Daniel J Elson, Roujih Tadros, Charisa E Gillette, Carley Coopwood, Amy L Rausch, Jeffrey M Snowbarger
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252233 (2021)
Tumor angiogenesis is critical for the growth and progression of cancer. As such, angiostasis is a treatment modality for cancer with potential utility for multiple types of cancer and fewer side effects. However, clinical success of angiostatic mono
Externí odkaz:
https://doaj.org/article/2bcc474f3f2743d2ae3bcf6edb8e2f29
Publikováno v:
Journal of Comorbidity, Vol 10 (2020)
Objective: To examine the relationship between multimorbidity and mortality, and whether relationship varied by material deprivation/rural location and by age. Methods: Retrospective population-based cohort study conducted using 2013–14 data from p
Externí odkaz:
https://doaj.org/article/ae4a0d3f7f02486da827e2ef9306a800
Autor:
Tito Borner, Jayme L. Workinger, Ian C. Tinsley, Samantha M. Fortin, Lauren M. Stein, Oleg G. Chepurny, George G. Holz, Aleksandra J. Wierzba, Dorota Gryko, Ebba Nexø, Evan D. Shaulson, Ankur Bamezai, Valentina A. Rodriguez Da Silva, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107768- (2020)
Summary: Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activat
Externí odkaz:
https://doaj.org/article/e5149ea465c3458cb9a6f4de1b3228fc
Publikováno v:
Nutrients, Vol 13, Iss 5, p 1642 (2021)
The mesencephalic trigeminal nucleus (Mes5) processes oral sensory–motor information, but its role in the control of energy balance remains unexplored. Here, using fluorescent in situ hybridization, we show that the Mes5 expresses the melanocortin-
Externí odkaz:
https://doaj.org/article/aba744b401ef4e9b92c81adb13f5b1b8
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