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Publikováno v:
Gynecologic Oncology. 99:S89-S94
Background. Quantum dots (qdots) are a promising alternative to organic fluorophores for biological imaging. Advantages of quantum dots over organic fluorophores include broad excitation coupled with narrow, tunable emission, high resistance to chemi
Publikováno v:
IEEE Journal of Selected Topics in Quantum Electronics. 9:307-313
Most models of light propagation through tissue assume the scattering properties of the various tissue layers are the same. The authors present evidence that the scattering coefficient of normal cervical epithelium is significantly lower than values
Autor:
M. Follen, Rebecca Richards-Kortum, Chen Liang, Michael R. Descour, Kung-Bin Sung, Tom Collier
Publikováno v:
IEEE Transactions on Biomedical Engineering. 49:1168-1172
We have built a fiber-optic confocal reflectance microscope capable of imaging human tissues in near real time. Miniaturization of the objective lens and the mechanical components for positioning and axially scanning the objective enables the device
Autor:
Urs Utzinger, Dennis D. Cox, Gregg A Staerkel, M. Follen, Sung K. Chang, E. Neely Atkinson, Rebecca Richards-Kortum, A. Malpica, Calum MacAulay
Publikováno v:
IEEE Transactions on Biomedical Engineering. 49:1102-1111
Fluorescence spectroscopy has shown promise for the in vivo, real-time detection of cervical neoplasia. However, selection of excitation wavelength has in the past been based on in vitro studies and the availability of light sources. The goal of this
Autor:
M. Follen, Michael R. Descour, Rebecca Richards-Kortum, Chen Liang, A. Malpica, Kung-Bin Sung, Tom Collier
Publikováno v:
Journal of Microscopy. 207:137-145
We have built a fibre optic confocal reflectance microscope capable of imaging biological tissue in near real time. The measured lateral resolution is 3 micro m and axial resolution is 6 micro m. Images of epithelial cells, excised tissue biopsies, a
Autor:
R, Drezek, C, Brookner, I, Pavlova, I, Boiko, A, Malpica, R, Lotan, M, Follen, R, Richards-Kortum
Publikováno v:
Photochemistry and Photobiology. 73:636-641
Fluorescence spectroscopy offers an effective, noninvasive approach to the detection of precancers in multiple organ sites. Clinical studies have demonstrated that fluorescence spectroscopy can provide highly sensitive, specific and cost-effective di
Publikováno v:
Oral Oncology. 35:415-420
Human papillomaviruses (HPVs) have been strongly linked to progression of human cancers, such as cervical and oral cancers. Two HPV oncoproteins, E6 and E7, can inhibit the tumor suppressor proteins, p53 and pRB, respectively, resulting in a deregula
Autor:
Rebecca Richards-Kortum, M. Follen Mitchell, Urs Utzinger, E. V. Trujillo, Nirmala Ramanujam, D. R. Sandison
Publikováno v:
Applied Spectroscopy. 52:943-951
Recent clinical trials have demonstrated the potential of fluorescence spectroscopy for in vivo diagnosis of pathology. There is significant potential to reduce the cost and complexity of instrumentation to measure tissue spectra; however, careful an
Autor:
Calum MacAulay, Catherine Poh, J. Scott Durham, Lewei Zhang, Sylvia F. Lam, Miriam P. Rosin, M Guillaud, J McAlpine, T Ehlen, D Miller, D van Niekerk, M Follen, Pierre M. Lane
Publikováno v:
Optics in the Life Sciences.
Improved detection and delineation of pre-invasive and invasive cancers can be effected through recording the changes in optical properties detected by auto-fluorescence imaging, resulting in statistically improved patient outcomes (oral) and improve