Výsledky vyhledávání - "M, Fethi Sahin"

Novel and Stereospecific Synthesis of (2S)-3-(2,4,5-Trifluorophenyl)propane-1,2-diol fromD-Mannitol

Autor: Yunus Kara, Derya Aktaş, Hasan Seçen, Özlem Gündoğdu, Meryem Fistikci, Ramazan Altundas, M. Fethi Sahin

Publikováno v: Helvetica Chimica Acta. 98:1127-1131

A stereospecific synthesis of (2S)-3-(2,4,5-trifluorophenyl)propane-1,2-diol from D-mannitol has been developed. The reaction of 2,3-O-isopropylidene-D-glyceraldehyde with 2,4,5-trifluorophenylmagnesium bromide gave [(4R)-2,2-dimethyl-1,3-dioxolan-4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b54d63ae36dd6d8f9ca725832f012960
https://doi.org/10.1002/hlca.201500031

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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW MANNICH BASES OF 7-ACYL-5-CHLORO-2-OXO-3H-BENZOXAZOLE DERIVATIVES

Autor: Sultan Nacak, Berna Özçelik, Serdar Ünlü, M. Fethi Sahin, Semiha Özkan, Ufuk Abbasoglu

Publikováno v: Turkish Journal of Pharmaceutical Sciences, Vol 2, Iss 1, Pp 25-33 (2005)

A series of novel Mannich bases of 7-acyl-5-chloro-2-oxo-3H-benzoxazoles were synthesized by reacting them with formaldehyde and several seconder amine derivatives. Their chemical structures were elucidated by means of their IR, 1H-NMR data and by el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::ad51984e30869cdfc3452f236e815ff9
http://www.turkjps.org/archives/archive-detail/article-preview/synthess-and-antmcrobal-actvty-of-some-new-mannch-/12586

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Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid: a synthon for sitagliptin and its derivatives

Autor: Özlem Gündoğdu, Yunus Kara, Meryem Fistikci, Ramazan Altundas, Hasan Seçen, Derya Aktaş, M. Fethi Sahin

A new synthetic strategy for (R)- and (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid, a building block in the preparation of sitagliptin and its derivatives, was developed. Pd(OAc)(2) catalyzed coupling of 2,4,5-trifluoro-1-iodobenzene with all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b895022cd5db36fc6aa5967e7b78550
https://hdl.handle.net/20.500.12814/797

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Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors

Autor: Yasemin, Dündar, Serdar, Unlü, Erden, Banoğlu, Antonio, Entrena, Gabriele, Costantino, Maria-Teresa, Nuñez, Maria-Teresa, Nunez, Luis, Labeaga, Francisco, Ledo, M Fethi, Sahin, Ningur, Noyanalpan

A series of 3-unsubstituted/substituted-4,5-diphenyl-2-oxo-3H-1,3-oxazole derivatives were prepared as selective cyclooxygenase-2 (COX-2) inhibitors. Among the synthesized compounds, 4-(4-phenyl-3-methyl-2-oxo-3H-1,3-oxazol-5-yl)benzensulfonamide (co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c752a2b47e20b598cedad1bd3d6974
https://avesis.gazi.edu.tr/publication/details/043d3ff2-9f14-4d64-b55e-cea911b18bf6/oai

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Synthesis of 2(3H)-benzothiazolinone derivatives as analgesic and anti-inflammatory agents

Autor: Yasemin DÜNDAR, Bilge ÇAKIR, Esra KÜPELI, M. Fethi SAHIN

Publikováno v: Turkish Journal of Pharmaceutical Sciences, Vol 3, Iss 2, Pp 51-60 (2006)

In this study, we have synthesized new 1-(4-(2-oxobenzothiazolin-3-yl)butyl-4-substituted piperazine, 1-(4-(2-oxobenzothiazolin-3-yl)butanoyl-4-substituted piperazine and 3-(4-(2-oxo-1,3-benzothiazol-2(3H)-yl)butyl)-1,3-benzothiazol-2(3H)-one derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::151a40e4be2e52bc51b539efedb83e5e
https://avesis.gazi.edu.tr/publication/details/e8ae94b8-bdd9-488f-95a3-18b8c0eb04b6/oai

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Structure-activity studies on a potent antagonist to organophosphate-induced toxicity

Autor: Joseph G. Cannon, Jan R. Flynn, John P. Long, Ranbir K. Bhatnagar, M. Fethi Sahin

Publikováno v: Journal of Medicinal Chemistry. 34:1582-1584

Molecular modifications have been made on a highly potent, active antagonist to organophosphate-induced toxicity, 4,4'-bis[1,3-dioxan-2-ylmethyl)methylamino]acetyl]biphenyl dimethobromide (1). Stepwise removal of the oxygen atoms from the dioxane rin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baee8f7a8ab75552539334461c541d35
https://doi.org/10.1021/jm00109a009

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N-(2-pyridinyl)-2-[2(3H)-benzazolone-3-yl]acetamides: synthesis, antinociceptive and anti-inflammatory activity

Autor: D S, Doğruer, S, Unlü, E, Yeşilada, M, Fethi Sahin

Publikováno v: Farmaco (Societa chimica italiana : 1989). 52(12)

Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis, IR and 1H NMR spectral data and their antinociceptive and anti-inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7542c364245eca5fd475f33ae6ab97ff
https://pubmed.ncbi.nlm.nih.gov/9648280

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