A Multi-omics Study of Circulating Phospholipid Markers of Blood Pressure

Autor: M. Fabiola Del Greco, Katharina E. Schraut, Cornelia M. van Duijn, Ko Willems van Dijk, Ozren Polasek, Veronique Vitart, Peter P. Pramstaller, Andrew A. Hicks, Jun Liu, James F. Wilson, Åsa Johansson, Oscar H. Franco, Caroline Hayward, Paul S. de Vries, Abbas Dehghan, Ulf Gyllensten, Igor Rudan, Ayse Demirkan, Harry Campbell

Background High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct an in depth multi-omics study of various phospholipids with systolic blood pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34610b767afa29cc995ca22039303ff3
https://doi.org/10.21203/rs.3.rs-650961/v1

Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Autor: M Fabiola Del Greco, Sandeep Grover, Inke R. König

Publikováno v: Systematic Reviews, Vol 7, Iss 1, Pp 1-6 (2018)

Background Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7df7de358d978aaa7e111654d19b74
http://link.springer.com/article/10.1186/s13643-018-0809-3

Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease

Autor: Shafqat Ahmad, Christina M Astley, Ruth J. F. Loos, Evangelos Evangelou, M. Fabiola Del Greco, Barbara McKnight, Helen R. Warren, Sonja I. Berndt, Carolina Medina-Gomez, Eirini Marouli, Jana V. van Vliet-Ostaptchouk, Joel N. Hirschhorn, Panos Deloukas, Zhihong Zhu, Mark J. Caulfield, Zoltán Kutalik, Jian Yang

Publikováno v: Communications Biology, Vol 2, Iss 1, Pp 1-9 (2019)
Communications biology, 2:119. Nature Publishing Group
Communications Biology
Communications biology, vol. 2, pp. 119
Communications Biology, 2:119. Springer Nature

There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe2f1b7ec0718d2b1c1472d7c90216d
https://doi.org/10.1038/s42003-019-0361-2

52 Genetic Loci Influencing Myocardial Mass

Autor: Alan F. Wright, Cisca Wijmenga, Bruno H. Stricker, Peter W. Macfarlane, Edward G. Lakatta, Uwe Völker, Lenore J. Launer, Olli T. Raitakari, Stephan B. Felix, Toshiko Tanaka, Osorio Meirelles, Phil Barnett, Thomas Meitinger, Albert Hofman, Bosco Trinh, Tamara B. Harris, Peter M. Okin, Axel Visel, Teresa Nutile, Claudia T. Silva, Harry Campbell, Ilja M. Nolte, M. Fabiola Del Greco, Terho Lehtimäki, Shih-Jen Hwang, Alicia Lundby, Kamil Slowikowski, Luigi Ferrucci, Joshua C. Bis, Jerome I. Rotter, Nona Sotoodehnia, Sebastian Schafer, Igor Rudan, Ozren Polasek, Vinicius Tragante, Kenneth Rice, Connie R. Bezzina, Siegfried Perz, Aravinda Chakravarti, Paul I.W. de Bakker, Jared W. Magnani, Xinchen Wang, Yigal M. Pinto, Carsten Oliver Schmidt, Marcus Dörr, Peter P. Pramstaller, Jobanpreet Sehmi, Susan R. Heckbert, Richard B. Devereux, Jesper V. Olsen, Sheila Ulivi, Shane Neph, Peter M. Visscher, James F. Wilson, Alexander Nord, Tim D. Spector, Stefan Kääb, Elsayed Z. Soliman, Weihua Zhang, Lin Y. Chen, Pim van der Harst, Veronique Vitart, Anna F. Dominiczak, Mark Eijgelsheim, Pieter A. Doevendans, Josef M. Penninger, Jaspal S. Kooner, Georg Vogler, Patricia B. Munroe, Soumya Raychaudhuri, Christian Gieger, Harold Snieder, Annamaria Iorio, Caroline Hayward, Yalda Jamshidi, Mika Kähönen, Jessica van Setten, Wilko Spiering, Ian Ford, Andrew A. Hicks, John C. Chambers, Joel N. Hirschhorn, Matthew T. Maurano, Niek Verweij, Maria Grazia Pilia, Rolf Bodmer, Vilmundur Gudnason, Ben A. Oostra, Megan V. Cannon, Nilesh J. Samani, Bruce H. R. Wolffenbuttel, Annette Peters, David Schlessinger, Daniel Levy, J. Wouter Jukema, Malou van den Boogaard, Brendan M. Buckley, Arne Pfeufer, Michiel E. Adriaens, Rossella Sorice, Matthias Heinig, Jian Yang, Norbert Hubner, Stefania Bandinelli, André G. Uitterlinden, Hans L. Hillege, Martina Müller-Nurasyid, Andres Metspalu, Eric Haugen, Laurie A. Boyer, Ronald P. Stolk, Gonçalo R. Abecasis, Dan E. Arking, Manolis Kellis, Ishminder K. Kooner, Leo-Pekka Lyytikäinen, Dena G. Hernandez, Dirk J. van Veldhuisen, Len A. Pennacchio, Kasper Lage, Gianfranco Sinagra, Bruce M. Psaty, Christopher Newton-Cheh, Cornelia M. van Duijn, Stefania Nappo, Dalit May, Paolo Gasparini, Elizabeth J. Rossin, Rudolf A. de Boer, Alessandro P Delitala, Tõnu Esko, John A. Stamatoyannopoulos, Aaron Isaacs, Kathleen F. Kerr, Sian Tsung Tan, Tune H. Pers, Serena Sanna, Melanie Waldenberger, Marina Ciullo, Jorma Viikari, Vincent M. Christoffels, Bram P. Prins, Alvaro Alonso, Sandosh Padmanabhan, Harm-Jan Westra, Moritz F. Sinner, Albert V. Smith, Kirill V. Tarasov, Konstantin Strauch, Wiek H. van Gilst, Christian X. Weichenberger, Lude Franke, Folkert W. Asselbergs, Herman H W Silljé, Jan A. Kors, Irene Mateo Leach, Karl Andersen, Ivana Kolcic, Stella Trompet, Silvia Naitza

Publikováno v: Elsevier
Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Science
Journal of The American College of Cardiology
Journal of the American College of Cardiology, 68(13), 1435. Elsevier USA
van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-1448 . https://doi.org/10.1016/j.jacc.2016.07.729
Journal of the American College of Cardiology
68 (2016): 1435–1448. doi:10.1016/j.jacc.2016.07.729
info:cnr-pdr/source/autori:van der Harst, Pim; van Setten, Jessica; Verweij, Niek; Vogler, Georg; Franke, Lude; Maurano, Matthew T.; Wang, Xinchen; Leach, Irene Mateo; Eijgelsheim, Mark; Sotoodehnia, Nona; Hayward, Caroline; Sorice, Rossella; Meirelles, Osorio; Lyytikainen, Leo-Pekka; Polasek, Ozren; Tanaka, Toshiko; Arking, Dan E.; Ulivi, Sheila; Trompet, Stella; Mueller-Nurasyid, Martina; Smith, Albert V.; Doerr, Marcus; Kerr, Kathleen F.; Magnani, Jared W.; Del Greco, Fabiola; Zhang, Weihua; Nolte, Ilja M.; Silva, Claudia T.; Padmanabhan, Sandosh; Tragante, Vinicius; Esko, Tonu; Abecasis, Gonclo R.; Adriaens, Michiel E.; Andersen, Karl; Barnett, Phil; Bis, Joshua C.; Bodmer, Rolf; Buckley, Brendan M.; Campbell, Harry; Cannon, Megan V.; Chakravarti, Aravinda; Chen, Lin Y.; Delitala, Alessandro; Devereux, Richard B.; Doevendans, Pieter A.; Dominiczak, Anna F.; Ferrucci, Luigi; Ford, Ian; Gieger, Christian; Harris, Tamara B.; Haugen, Eric; Heinig, Matthias; Hernandez, Dena G.; Hillege, Hans L.; Hirschhorn, Joel N.; Hofman, Albert; Hubner, Norbert; Hwang, Shih-Jen; Iorio, Annamaria; Kahonen, Mika; Kellis, Manolis; Kolcic, Ivana; Kooner, Ishminder K.; Kooner, Jaspal S.; Kors, Jan A.; Lakatta, Edward G.; Lage, Kasper; Launer, Lenore J.; Levy, Daniel; Lundby, Alicia; Macfarlane, Peter W.; May, Dalit; Meitinger, Thomas; Metspalu, Andres; Nappo, Stefania; Naitza, Silvia; Neph, Shane; Nord, Alex S.; Nutile, Teresa; Okin, Peter M.; Olsen, Jesper V.; Oostra, Ben A.; Penninger, Josef M.; Pennacchio, Len A.; Pers, Tune H.; Perz, Siegfried; Peters, Annette; Pinto, Yigal M.; Pfeufer, Arne; Pilia, Maria Grazia; Pramstaller, Peter P.; Prins, Bram P.; Raitakari, Olli T.; Raychaudhuri, Soumya; Rice, Ken M.; Rossin, Elizabeth J.; Rotter, Jerome I.; Schafer, Sebastian; Schlessinger, David; Schmidt, Carsten O.; Sehmi, Jobanpreet; Sillje, Herman H. W.; Sinagra, Gianfranco; Sinner, Moritz F.; Slowikowski, Kamil; Soliman, Elsayed Z.; Spector, Timothy D.; Spiering, Wilko; Stamatoyannopoulos, John A.; Stolk, Ronald P.; Strauch, Konstantin; Tan, Sian-Tsung; Tarasov, Kirill V.; Trinh, Bosco; Uitterlinden, Andre G.; van den Boogaard, Malou; van Duijn, Cornelia M.; van Gilst, Wiek H.; Viikari, Jorma S.; Visscher, Peter M.; Vitart, Veronique; Voelker, Uwe; Waldenberger, Melanie; Weichenberger, Christian X.; Westra, Harm-Jan; Wijmenga, Cisca; Wolffenbuttel, Bruce H.; Yang, Jian; Bezzina, Connie R.; Munroe, Patricia B.; Snieder, Harold; Wright, Alan F.; Rudan, Igor; Boyer, Laurie A.; Asselbergs, Folkert W.; van Veldhuisen, Dirk J.; Stricker, Bruno H.; Psaty, Bruce M.; Ciullo, Marina; Sanna, Serena; Lehtimaki, Terho; Wilson, James F.; Bandinelli, Stefania; Alonso, Alvaro; Gasparini, Paolo; Jukema, J. Wouter; Kaeaeb, Stefan; Gudnason, Vilmundur; Felix, Stephan B.; Heckbert, Susan R.; de Boer, Rudolf A.; Newton-Cheh, Christopher; Hicks, Andrew A.; Chambers, John C.; Jamshidi, Yalda; Visel, Axel; Christoffels, Vincent M.; Isaacs, Aaron; Samani, Nilesh J.; de Bakker, Paul I. W./titolo:52 Genetic Loci Influencing Myocardial Mass/doi:10.1016%2Fj.jacc.2016.07.729/rivista:Journal of the American College of Cardiology (Print)/anno:2016/pagina_da:1435/pagina_a:1448/intervallo_pagine:1435–1448/volume:68
Journal of the American College of Cardiology, 68(13), 1435-1448
van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729
Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier USA
Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Inc.
Journal of the American College of Cardiology, 68(13), 1435-1448. ELSEVIER SCIENCE INC
J. Am. Coll. Cardiol. 68, 1435-1448 (2016)
van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polasek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

BACKGROUND Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db2fc7f0a4c18983fe62e1ec6c7ffd5
https://doi.org/10.1016/j.jacc.2016.07.729

The Effect of Iron Status on Risk of Coronary Artery Disease: A Mendelian Randomization Study-Brief Report

Autor: Surjit K.S. Srai, Dipender Gill, Cosetta Minelli, M Fabiola Del Greco, Michael Laffan, Ann P. Walker

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 37(9)

Objective— Iron status is a modifiable trait that has been implicated in cardiovascular disease. This study uses the Mendelian randomization technique to investigate whether there is any causal effect of iron status on risk of coronary artery disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318e7beba044a37632f5f0fed26d8809
https://pubmed.ncbi.nlm.nih.gov/28684612